Abbasloo E, Najafipour H, Vakili A (2020) Chronic treatment with apelin, losartan and their combination reduces myocardial infarct size and improves cardiac mechanical function. Clin Exp Pharmacol Physiol 47(3):393–402. https://doi.org/10.1111/1440-1681.13195
Article CAS PubMed Google Scholar
Acele A, Bulut A, Donmez Y, Koc M (2020) Serum Elabela Level significantly increased in patients with Complete Heart Block. Brazilian J Cardiovasc Surg 35(5):683–688. https://doi.org/10.21470/1678-9741-2019-0461
An S, Wang X, Shi H, Zhang X, Meng H, Li W, Chen D, Ge J (2020) Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways. Aging 12(24):25120–25137. https://doi.org/10.18632/aging.104106
Article CAS PubMed PubMed Central Google Scholar
Arani Hessari F, Sharifi M, Yousefifard M, Gholamzadeh R, Nazarinia D, Aboutaleb N (2022) Apelin-13 attenuates cerebral ischemia/reperfusion injury through regulating inflammation and targeting the JAK2/STAT3 signaling pathway. J Chem Neuroanat 126:102171. https://doi.org/10.1016/j.jchemneu.2022.102171
Article CAS PubMed Google Scholar
Azizi Y, Faghihi M, Imani A, Roghani M, Nazari A (2013) Post-infarct treatment with [Pyr1]-apelin-13 reduces myocardial damage through reduction of oxidative injury and nitric oxide enhancement in the rat model of myocardial infarction. Peptides 46:76–82. https://doi.org/10.1016/j.peptides.2013.05.006
Article CAS PubMed Google Scholar
Azizi Y, Imani A, Fanaei H, Khamse S, Parvizi MR, Faghihi M (2017) Post-infarct treatment with [Pyr1]apelin-13 exerts anti-remodelling and anti-apoptotic effects in rats’ hearts. Kardiologia Polska 75(6):605–613. https://doi.org/10.5603/KP.a2017.0022
Bai B, Cai X, Jiang Y, Karteris E, Chen J (2014) Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via Gαq-mediated mechanism. J Cell Mol Med 18(10):2071–2081. https://doi.org/10.1111/jcmm.12404
Article CAS PubMed PubMed Central Google Scholar
Basir MB, Lemor A, Gorgis S, Taylor AM, Tehrani B, Truesdell AG, Bharadwaj A, Kolski B, Patel K, Gelormini J, Todd J, Lasorda D, Smith C, Riley R, Marso S, Federici R, Kapur NK, O’Neill WW, Investigators (2022) Vasopressors independently associated with mortality in acute myocardial infarction and cardiogenic shock. Catheter Cardiovasc Interv 99(3):650–657. https://doi.org/10.1002/ccd.29895
Becatti M, Taddei N, Cecchi C, Nassi N, Nassi PA, Fiorillo C (2012) SIRT1 modulates MAPK pathways in ischemic-reperfused cardiomyocytes. Cell Mol Life Sci 69(13):2245–2260. https://doi.org/10.1007/s00018-012-0925-5
Article CAS PubMed Google Scholar
Berry MF, Pirolli TJ, Jayasankar V, Burdick J, Morine KJ, Gardner TJ, Woo YJ (2004) Apelin has in vivo inotropic effects on normal and failing hearts. Circulation 110(11 Suppl 1):II187–193. https://doi.org/10.1161/01.CIR.0000138382.57325.5c
Article CAS PubMed Google Scholar
Bircan B, Çakır M, Kırbağ S, Gül HF (2016) Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats. Ren Fail 38(7):1122–1128. https://doi.org/10.1080/0886022X.2016.1184957
Article CAS PubMed Google Scholar
Birsen İ, İzgüt-Uysal VN, Soylu H, Üstünel İ (2020) The effect of apelin-13 on gastric ischemia/reperfusion injury: the roles of sensory nerves and vagus nerve. Can J Physiol Pharmacol 98(5):282–295. https://doi.org/10.1139/cjpp-2019-0502
Article CAS PubMed Google Scholar
Boal F, Roumegoux J, Alfarano C, Timotin A, Calise D, Anesia R, Drougard A, Knauf C, Lagente C, Roncalli J, Desmoulin F, Tronchere H, Valet P, Parini A, Kunduzova O (2015) Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity. Sci Rep 5:16104. https://doi.org/10.1038/srep16104
Article CAS PubMed PubMed Central Google Scholar
Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, Castan-Laurell I, Tack I, Knibiehler B, Carpéné C, Audigier Y, Saulnier-Blache J-S, Valet P (2005) Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146(4):1764–1771. https://doi.org/10.1210/en.2004-1427
Article CAS PubMed Google Scholar
Bülbül M, Sinen O, Bayramoğlu O, Akkoyunlu G (2020) Enteric apelin enhances the stress-induced stimulation of colonic motor functions. Stress 23(2):201–212. https://doi.org/10.1080/10253890.2019.1658739
Article CAS PubMed Google Scholar
Chapman NA, Dupré DJ, Rainey JK (2014) The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR. Biochemistry and Cell Biology = Biochimie. Et Biol Cellulaire 92(6):431–440. https://doi.org/10.1139/bcb-2014-0072
Chen MM, Ashley EA, Deng DXF, Tsalenko A, Deng A, Tabibiazar R, Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R, Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS, Quertermous T (2003) Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation 108(12):1432–1439. https://doi.org/10.1161/01.CIR.0000091235.94914.75
Article CAS PubMed Google Scholar
Chen H, Wan D, Wang L, Peng A, Xiao H, Petersen RB, Liu C, Zheng L, Huang K (2015) Apelin protects against acute renal injury by inhibiting TGF-β1. Biochim Biophys Acta 1852(7):1278–1287. https://doi.org/10.1016/j.bbadis.2015.02.013
Article CAS PubMed Google Scholar
Chen Y, Qiao X, Zhang L, Li X, Liu Q (2020a) Apelin-13 regulates angiotensin ii-induced Cx43 downregulation and autophagy via the AMPK/mTOR signaling pathway in HL-1 cells. Physiol Res 69(5):813–822. https://doi.org/10.33549/physiolres.934488
Article CAS PubMed PubMed Central Google Scholar
Chen P, Wang Y, Chen L, Song N, Xie J (2020b) Apelin-13 protects dopaminergic neurons against Rotenone-Induced neurotoxicity through the AMPK/mTOR/ULK-1 mediated autophagy activation. Int J Mol Sci 21(21):8376. https://doi.org/10.3390/ijms21218376
Article CAS PubMed PubMed Central Google Scholar
Chng SC, Ho L, Tian J, Reversade B (2013) ELABELA: a hormone essential for heart development signals via the apelin receptor. Dev Cell 27(6):672–680. https://doi.org/10.1016/j.devcel.2013.11.002
Article CAS PubMed Google Scholar
Chu H, Yang X, Huang C, Gao Z, Tang Y, Dong Q (2017) Apelin-13 protects against ischemic blood-brain barrier damage through the effects of Aquaporin-4. Cerebrovasc Dis 44(1–2):10–25. https://doi.org/10.1159/000460261
Article CAS PubMed Google Scholar
Collino M, Thiemermann C, Cerami A, Brines M (2015) Flipping the molecular switch for innate protection and repair of tissues: long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin. Pharmacol Ther 151:32–40. https://doi.org/10.1016/j.pharmthera.2015.02.005
Article CAS PubMed Google Scholar
de Oliveira AA, Vergara A, Wang X, Vederas JC, Oudit GY (2022) Apelin pathway in cardiovascular, kidney, and metabolic diseases: therapeutic role of apelin analogs and apelin receptor agonists. Peptides 147:170697. https://doi.org/10.1016/j.peptides.2021.170697. https://www.sciencedirect.com/science/article/pii/S0196978121002059
Article CAS PubMed Google Scholar
Deng C, Chen H, Yang N, Feng Y, Hsueh AJW (2015) Apela regulates Fluid Homeostasis by binding to the APJ receptor to activate Gi Signaling. J Biol Chem 290(30):18261–18268. https://doi.org/10.1074/jbc.M115.648238
Article CAS PubMed PubMed Central Google Scholar
Ding M, Lei J, Han H, Li W, Qu Y, Fu E, Fu F, Wang X (2015) SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats. Cardiovasc Diabetol 14:143. https://doi.org/10.1186/s12933-015-0299-8
Article CAS PubMed PubMed Central Google Scholar
Dönmez Y, Acele A (2019) Increased elabela levels in the acute ST segment elevation myocardial infarction patients. Medicine 98(43):e17645. https://doi.org/10.1097/MD.0000000000017645
Article CAS PubMed PubMed Central Google Scholar
Duan J, Cui J, Yang Z, Guo C, Cao J, Xi M, Weng Y, Yin Y, Wang Y, Wei G, Qiao B, Wen A (2019) Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling. J Neuroinflamm 16(1):24. https://doi.org/10.1186/s12974-019-1406-7
Fan X-F, Xue F, Zhang Y-Q, Xing X-P, Liu H, Mao S-Z, Kong X-X, Gao Y-Q, Liu SF, Gong Y-S (2015) The Apelin-APJ axis is an endogenous counterinjury mechanism in experimental acute lung injury. Chest 147(4):969–978. https://doi.org/10.1378/chest.14-1426
Folino A, Accomasso L, Giachino C, Montarolo PG, Losano G, Pagliaro P, Rastaldo R (2018) Apelin-induced cardioprotection against ischaemia/reperfusion injury: Roles of epidermal growth factor and Src. Acta Physiologica (Oxford England) 222(2):e12924
Garcia S, Schmidt CW, Garberich R, Henry TD, Bradley SM, Brilakis ES, Burke N, Chavez IJ, Eckman P, Gössl M, Mooney MR, Newell MC, Poulose AK, Sorajja P, Traverse JH, Wang YL, Sharkey SW (2021) Temporal changes in patient characteristics and outcomes in ST-segment elevation myocardial infarction 2003–2018. Catheter Cardiovasc Interv 97(6):1109–1117. https://doi.org/10.1002/ccd.28901
留言 (0)