Alni RH, Tavasoli F, Barati A, Badarbani SS, Salimi Z, Babaeekhou L (2020) Synergistic activity of melittin with mupirocin: A study against methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolates. Saudi J Biol Sci 27(10):2580–2585. https://doi.org/10.1016/j.sjbs.2020.05.027

Askari P, Namaei MH, Ghazvini K, Hosseini M (2021) In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria. BMC Pharmacol Toxicol 22:42. https://doi.org/10.1186/s40360-021-00503-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babaeekhou L, Ghane M, Mohammad Rafiee M (2023) Photodynamic therapy and its synergism with melittin against drug-resistant Acinetobacter baumannii isolates with high biofilm formation ability. Curr Microbiol 80:324. https://doi.org/10.1007/s00284-023-03356-3

Article  CAS  PubMed  Google Scholar 

Bano S, Hassan N, Rafiq M, Hassan F, Rehman M, Iqbal N, Ali H, Hasan F, Kang YQ (2023) Biofilms as battlefield armor for bacteria against antibiotics: challenges and combating strategies. Microorganisms 11(10):2595. https://doi.org/10.3390/microorganisms11102595

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bardbari AM, Arabestani MR, Karami M, Keramat F, Aghazadeh H, Alikhani MY, Bagheri KP (2018) Highly synergistic activity of melittin with imipenem and colistin in biofilm inhibition against multidrug-resistant strong biofilm producer strains of Acinetobacter baumannii. Eur J Clin Microbiol Infect Dis 37:443–454. https://doi.org/10.1007/s10096-018-3189-7

Article  CAS  PubMed  Google Scholar 

Bello J, Bello HR, Granados E (1982) Conformation and aggregation of melittin: dependence of pH and concentration. Biochemistry 21(3):461–465. https://doi.org/10.1021/bi00532a007

Article  CAS  PubMed  Google Scholar 

Blackman LD, Qu Y, Cass P, Locock KE (2021) Approaches for the inhibition and elimination of microbial biofilms using macromolecular agents. Chem Soc Rev 50(3):1587–1616. https://doi.org/10.1039/D0CS00986E

Article  CAS  PubMed  Google Scholar 

Bou Zeidan M, Carmona L, Zara S, Marcos JF (2013) FLO11 gene is involved in the interaction of flor strains of Saccharomyces cerevisiae with a biofilm-promoting synthetic hexapeptide. Appl Environ Microbiol 79(19):6023–6032. https://doi.org/10.1128/AEM.01647-13

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burmølle M, Ren D, Bjarnsholt T, Sørensen SJ (2014) Interactions in multispecies biofilms: do they actually matter? Trends Microbiol 22(2):84–91. https://doi.org/10.1016/j.tim.2013.12.004

Article  CAS  PubMed  Google Scholar 

Castillo-Juárez I, Blancas-Luciano BE, García-Contreras R, Fernández-Presas AM (2022) Antimicrobial peptides properties beyond growth inhibition and bacterial killing. PeerJ 10:e12667. https://doi.org/10.7717/peerj.12667

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chou S, Li Q, Wu H, Li J, Chang YF, Shang L, Li J, Wang Z, Shan A (2021) Selective antifungal activity and fungal biofilm inhibition of tryptophan center symmetrical short peptide. Int J Mol Sci 22(15):8231. https://doi.org/10.3390/ijms22158231

Article  CAS  PubMed  PubMed Central  Google Scholar 

Costello KM, Smet C, Gutierrez-Merino J, Bussemaker M, Van Impe JF, Velliou EG (2021) The impact of food model system structure on the inactivation of Listeria innocua by cold atmospheric plasma and nisin combined treatments. Int J Food Microbiol 337:108948. https://doi.org/10.1016/j.ijfoodmicro.2020.108948

Article  CAS  PubMed  Google Scholar 

Coulter-Parkhill A, McClean S, Gault VA, Irwin N (2021) Therapeutic potential of peptides derived from animal venoms: current views and emerging drugs for diabetes. Clin Med Insights Endocrinol Diabetes 2021:14. https://doi.org/10.1177/11795514211006071

Das T, Kutty SK, Kumar N, Manefield M (2013) Pyocyanin facilitates extracellular DNA binding to Pseudomonas aeruginosa influencing cell surface properties and aggregation. PLoS ONE 8(3):e58299. https://doi.org/10.1371/journal.pone.0058299

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Gregorio E, Del Franco M, Martinucci M, Roscetto E, Zarrilli R, Di Nocera PP (2015) Biofilm-associated proteins: news from Acinetobacter. BMC Genomics 16:933. https://doi.org/10.1186/s12864-015-2136-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

del Mar Cendra M, Torrents E (2021) Pseudomonas aeruginosa biofilms and their partners in crime. Biotechnol Adv 49:107734. https://doi.org/10.1016/j.biotechadv.2021.107734

Article  CAS  Google Scholar 

Del Pozo JL (2018) Biofilm-related disease. Expert Rev Anti Infect Ther 16(1):51–65. https://doi.org/10.1080/14787210.2018.1417036

Article  CAS  PubMed  Google Scholar 

Delattin N, De Brucker K, De Cremer K, Cammue PA, Thevissen B K (2017) Antimicrobial peptides as a strategy to combat fungal biofilms. Curr Top Med Chem 17(5):604–612. https://doi.org/10.2174/1568026616666160713142228

Article  CAS  PubMed  Google Scholar 

Dosler S, Karaaslan E (2014) Inhibition and destruction of Pseudomonas aeruginosa biofilms by antibiotics and antimicrobial peptides. Peptides 62:32–37. https://doi.org/10.1016/j.peptides.2014.09.021

Article  CAS  PubMed  Google Scholar 

Dosler S, Karaaslan E, Alev Gerceker A (2016) Antibacterial and anti-biofilm activities of melittin and colistin, alone and in combination with antibiotics against Gram-negative bacteria. J Chemother 28(2):95–103. https://doi.org/10.1179/1973947815Y.0000000004

Article  CAS  PubMed  Google Scholar 

El-Seedi H, Abd El-Wahed A, Yosri N, Musharraf SG, Chen L, Moustafa M, Zou X, Al-Mousawi S, Guo Z, Khatib A, Khalifa S (2020) Antimicrobial properties of Apis mellifera’s bee venom. Toxins 12(7):451. https://doi.org/10.3390/toxins12070451

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elias S, Banin E (2012) Multi-species biofilms: living with friendly neighbors. FEMS Microbiol Rev 36(5):990–1004. https://doi.org/10.1111/j.1574-6976.2012.00325.x

Article  CAS  PubMed  Google Scholar 

Esposito MM, Turku S (2023) The use of natural methods to control foodborne biofilms. Pathogens 12(1):45. https://doi.org/10.3390/pathogens12010045

Article  CAS  Google Scholar 

Fleming D, Rumbaugh KP (2017) Approaches to dispersing medical biofilms. Microorganisms 5(2):15. https://doi.org/10.3390/microorganisms5020015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flemming HC, Wingender J (2010) The biofilm matrix. Nat Rev Microbiol 8:623–633. https://doi.org/10.1038/nrmicro2415

Article  CAS  PubMed  Google Scholar 

Fredheim EGA, Granslo HN, Flægstad T, Figenschau Y, Rohde H, Sadovskaya I, Mollnes TE, Klingenberg C (2011) Staphylococcus epidermidis polysaccharide intercellular adhesin activates complement. FEMS Immunol Med Microbiol 63(2):269–280. https://doi.org/10.1111/j.1574-695X.2011.00854.x

Article  CAS  PubMed  Google Scholar 

Gajski G, Garaj-Vrhovac V (2013) Melittin: a lytic peptide with anticancer properties. Environ Toxicol Pharmacol 36(2):697–705. https://doi.org/10.1016/j.etap.2013.06.009

Article  CAS  PubMed  Google Scholar 

Galdiero E, Siciliano A, Gesuele R, Di Onofrio V, Falanga A, Maione A, Liguori R, Libralato G, Guida M (2019) Melittin inhibition and eradication activity for resistant polymicrobial biofilm isolated from a dairy industry after disinfection. Int J Microbiol 2019(2019):4012394. https://doi.org/10.1155/2019/4012394

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galzitskaya OV (2023) Creation of new antimicrobial peptides. Int J Mol Sci 24(11):9451. https://doi.org/10.3390/ijms24119451

Article  PubMed  PubMed Central  Google Scholar 

Gopal R, Lee JH, Kim YG, Kim MS, Seo CH, Park Y (2013) Anti-microbial, anti-biofilm activities and cell selectivity of the NRC-16 peptide derived from witch flounder, Glyptocephalus cynoglossus. Mar Drugs 11(6):1836–1852. https://doi.org/10.3390/md11061836

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grassi L, Maisetta G, Esin S, Batoni G (2017) Combination strategies to enhance the efficacy of antimicrobial peptides against bacterial biofilms. Front Microbiol 8:2409. https://doi.org/10.3389/fmicb.2017.02409

Article  PubMed  PubMed Central  Google Scholar 

Guha S, Ferrie RP, Ghimire J, Ventura CR, Wu E, Sun L, Kim SY, Wiedman GR, Hristova K, Wimley WC (2021) Applications and evolution of melittin, the quintessential membrane active peptide. Biochem Pharmacol 193:114769. https://doi.org/10.1016/j.bcp.2021.114769

Article  CAS  PubMed  PubMed Central  Google Scholar 

Habermann E (1972) Bee and wasp venoms. Science 177(4046):314–322. https://doi.org/10.1126/science.177.4046.314

Article  CAS  PubMed  Google Scholar 

Habimana O