Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases
Keywords
eosinophil
ancestral RNase
ancestral sequence reconstruction
RNase 2
RNase 3
eosinophil-derived neurotoxin
eosinophil cationic protein
chimeragenesis
molecular dynamics
protein evolution
structural biology
X-ray crystallography
AbbreviationsAncRNase
ancestral ribonuclease
EDN
eosinophil-derived neurotoxin
ECP
eosinophil cationic protein
MfR3
ribonuclease 3 from the crab-eating macaque, Macaca fascicularis
ChimR23
ribonuclease 2/3 chimera
tRNA
transfer ribonucleic acid
AMP
adenosine monophosphate
AMPs
antimicrobial peptides
ASR
ancestral sequence reconstruction
© 2024 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.
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