PJ Goebell has a consulting/advisory relationship with Bayer; received honoraria from Astellas, AstraZeneca, Bayer, BMS, Eisai, Ipsen, Janssen, Novartis, Pfizer, Roche and Sanofi; and received support for travel expenses from Astellas, AstraZeneca, Bayer, BMS, Eisai, Ipsen, Janssen, Novartis, Pfizer, Roche and Sanofi. R Raina is an employee of OPEN Health, which received funding from Bayer Healthcare Pharmaceuticals, Inc., to support this study. S Chen is an employee of and stockholder in Bayer Healthcare Pharmaceuticals, Inc. S Rege is a former employee of OPEN Health, which received funding from Bayer Healthcare Pharmaceuticals, Inc., to support this study. R Shah is a former employee of OPEN Health, which received funding from Bayer Healthcare Pharmaceuticals, Inc., to support this study. J Partridge Grossman is an employee of and stockholder in Bayer Healthcare Pharmaceuticals, Inc. A Reginald Waldeck is an employee of and stockholder in Bayer Healthcare Pharmaceuticals, Inc. The authors have no other competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.