Adam Brufsky has received grants from Agendia and AstraZeneca, and consulting fees or honoraria from AstraZeneca, Pfizer, Novartis, Lilly, Genentech/Roche, Seagen, Daiichi Sankyo, Merck, Agendia, Sanofi, and Puma. Xianchen Liu, Benjamin Li, Lynn McRoy, and Connie Chen are employees of and stockholders in Pfizer. Rachel M. Layman reports advisory/consultancy fees from Novartis, Eli Lilly, Pfizer, and Celcuity, and research/grant funding from Pfizer, Novartis, Eli Lilly, Zentalis, Puma, Celcuity, Accutar Biotechnology, and Arvinas. Hope S Rugo reports sponsored research to her institution from Pfizer, Merck, Novartis, Eli Lilly, Roche, Daiichi-Sankyo, Seagen, Macrogenics, Sermonix, Boehringer Ingelheim, Polyphor, AstraZeneca, Ayala, and Gilead, and honoraria from Puma, Samsung, and Mylan. The authors have no other competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript apart from those disclosed.