Løgstrup BB, Ellingsen T, Pedersen AB et al (2021) Cardiovascular risk and mortality in rheumatoid arthritis compared with diabetes mellitus and the general population. Rheumatology 60(3):1400–1409. https://doi.org/10.1093/RHEUMATOLOGY/KEAA374

Article  PubMed  Google Scholar 

van der Woude D, van der Helm-van Mil AHM (2018) Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis. Best Pract Res Clin Rheumatol 32(2):174–187. https://doi.org/10.1016/J.BERH.2018.10.005

Article  PubMed  Google Scholar 

Conforti A, Di Cola I, Pavlych V et al (2021) Beyond the joints, the extra-articular manifestations in rheumatoid arthritis. Autoimmun Rev 20(2):102735. https://doi.org/10.1016/J.AUTREV.2020.102735

Article  PubMed  Google Scholar 

Liao KP (2017) Cardiovascular disease in patients with rheumatoid arthritis. Trends Cardiovasc Med 27(2):136–140. https://doi.org/10.1016/J.TCM.2016.07.006

Article  PubMed  Google Scholar 

Maradit-Kremers H, Crowson CS, Nicola PJ et al (2005) Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum 52(2):402–411. https://doi.org/10.1002/ART.20853

Article  PubMed  Google Scholar 

Nicola PJ, Crowson CS, Maradit-Kremers H et al (2006) Contribution of congestive heart failure and ischemic heart disease to excess mortality in rheumatoid arthritis. Arthritis Rheum 54(1):60–67. https://doi.org/10.1002/ART.21560

Article  PubMed  Google Scholar 

Gabriel SE (2008) Cardiovascular morbidity and mortality in rheumatoid arthritis. Am J Med 121(10 SUPPL 1). https://doi.org/10.1016/J.AMJMED.2008.06.011

Rheumatology A, Center I, Hansildaar R et al (2021) Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout. Lancet Rheumatol 3(1):e58-e70. https://doi.org/10.1016/S2665-9913(20)30221-6

Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D (2008) Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Care Res (Hoboken) 59(12):1690–1697. https://doi.org/10.1002/ART.24092

Article  Google Scholar 

Avina-Zubieta JA, Thomas J, Sadatsafavi M, Lehman AJ, Lacaille D (2012) Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis 71(9):1524–1529. https://doi.org/10.1136/ANNRHEUMDIS-2011-200726

Article  PubMed  Google Scholar 

Boyer JF, Gourraud PA, Cantagrel A, Davignon JL, Constantin A (2011) Traditional cardiovascular risk factors in rheumatoid arthritis: a meta-analysis. Joint Bone Spine 78(2):179–183. https://doi.org/10.1016/J.JBSPIN.2010.07.016

Article  PubMed  Google Scholar 

Skeoch S, Bruce IN (2015) Atherosclerosis in rheumatoid arthritis: is it all about inflammation? Nature Rev Rheumatol 11(7):390–400. https://doi.org/10.1038/nrrheum.2015.40

Libby P (2012) Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 32(9):2045–2051. https://doi.org/10.1161/ATVBAHA.108.179705

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chia S, Qadan M, Newton R, Ludlam CA, Fox KAA, Newby DE (2003) Intra-arterial tumor necrosis factor-alpha impairs endothelium-dependent vasodilatation and stimulates local tissue plasminogen activator release in humans. Arterioscler Thromb Vasc Biol 23(4):695–701. https://doi.org/10.1161/01.ATV.0000065195.22904.FA

Article  CAS  PubMed  Google Scholar 

Legein B, Temmerman L, Biessen EAL, Lutgens E (2013) Inflammation and immune system interactions in atherosclerosis. Cell Mol Life Sci 70(20):3847–3869. https://doi.org/10.1007/S00018-013-1289-1

Article  CAS  PubMed  Google Scholar 

Hossain MB, Kopec JA, Atiquzzaman M, Karim ME (2022) The association between rheumatoid arthritis and cardiovascular disease among adults in the United States during 1999–2018, and age-related effect modification in relative and absolute scales. Ann Epidemiol 71:23–30. https://doi.org/10.1016/j.annepidem.2022.03.005

Article  PubMed  Google Scholar 

Fraenkel L, Bathon JM, England BR et al (2021) 2021 American College of Rheumatology Guideline for the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken) 73(7):924–939. https://doi.org/10.1002/ACR.24596

Article  PubMed  Google Scholar 

Ytterberg SR, Bhatt DL, Mikuls TR et al (2022) Cardiovascular and cancer risk with tofacitinib in rheumatoid arthritis. N Engl J Med 386(4):316–326. https://doi.org/10.1056/NEJMOA2109927/SUPPL_FILE/NEJMOA2109927_DATA-SHARING.PDF

Article  CAS  PubMed  Google Scholar 

Nurmohamed MT (2009) Cardiovascular risk in rheumatoid arthritis. Autoimmun Rev 8(8):663–667. https://doi.org/10.1016/j.autrev.2009.02.015

Article  PubMed  Google Scholar 

Fakih O, Desmarets M, Martin B et al (2023) Impact of NSAIDs on 8-year cumulative incidence of major cardiovascular events in patients with ankylosing spondylitis: a nationwide study. Rheumatology (Oxford). Published online. https://doi.org/10.1093/RHEUMATOLOGY/KEAD072

Roubille C, Richer V, Starnino T et al (2015) The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis. Ann Rheum Dis 74(3):480–489. https://doi.org/10.1136/ANNRHEUMDIS-2014-206624

Article  CAS  PubMed  Google Scholar 

Eder L, Thavaneswaran A, Chandran V, Cook R, Gladman DD (2015) Increased burden of inflammation over time is associated with the extent of atherosclerotic plaques in patients with psoriatic arthritis. Ann Rheum Dis 74(10):1830–1835. https://doi.org/10.1136/ANNRHEUMDIS-2014-205267

Article  CAS  PubMed  Google Scholar 

Heslinga M, Van Den Oever IAM, Jonker DL et al (2019) Suboptimal cardiovascular risk management in rheumatoid arthritis patients despite an explicit cardiovascular risk screening programme. Scand J Rheumatol 48(5):345–352. https://doi.org/10.1080/03009742.2019.1600718

Article  CAS  PubMed  Google Scholar 

Van Den Oever IAM, Heslinga M, Griep EN et al Cardiovascular risk management in rheumatoid arthritis patients still suboptimal: the Implementation of Cardiovascular Risk Management in Rheumatoid Arthritis project. https://doi.org/10.1093/rheumatology/kew497

U-prevent. Accessed November 2, 2023. https://u-prevent.nl/accept-terms

Raadsen R, Agca R, Boers M et al (2023) In RA patients without prevalent CVD, incident CVD is mainly associated with traditional risk factors: a 20-year follow-up in the CARRÉCARR´CARRÉ cohort study. Semin Arthritis Rheum 58:152132. https://doi.org/10.1016/j.semarthrit.2022.152132

Article  CAS  PubMed  Google Scholar 

Chang K, Yang SM, Kim SH, Han KH, Park SJ, Shin J (2014) Il. Smoking and rheumatoid arthritis. Int J Mol Sci 15(12):22279–22295. https://doi.org/10.3390/IJMS151222279

Saevarsdottir S, Rezaei H, Geborek P et al (2015) Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritis: results from the SWEFOT trial. Ann Rheum Dis 74(8):1509–1514. https://doi.org/10.1136/ANNRHEUMDIS-2013-204601

Article  PubMed  Google Scholar 

Siasos G, Tsigkou V, Kokkou E et al (2014) Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches. Curr Med Chem 21(34):3936–3948. https://doi.org/10.2174/092986732134141015161539

Article  CAS  PubMed  Google Scholar 

Derksen VFAM, Huizinga TWJ, van der Woude D (2017) The role of autoantibodies in the pathophysiology of rheumatoid arthritis. Semin Immunopathol 39(4):437–446. https://doi.org/10.1007/S00281-017-0627-Z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hyrich KL, Watson KD, Silman AJ, Symmons DPM (2006) Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology (Oxford) 45(12):1558–1565. https://doi.org/10.1093/RHEUMATOLOGY/KEL149

Article  CAS  PubMed  Google Scholar 

Law-Wan J, Sparfel MA, Derolez S et al (2021) Predictors of response to TNF inhibitors in rheumatoid arthritis: an individual patient data pooled analysis of randomised controlled trials. Open 7:1882. https://doi.org/10.1136/rmdopen-2021-001882

Article  Google Scholar 

Messner B, Bernhard D (2014) Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol 34(3):509–515. https://doi.org/10.1161/ATVBAHA.113.300156

Article  CAS  PubMed  Google Scholar 

Roelsgaard IK, Ikdahl E, Rollefstad S et al (2020) Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients. Rheumatology (Oxford) 59(8):1997–2004. https://doi.org/10.1093/RHEUMATOLOGY/KEZ557

Article  CAS  PubMed  Google Scholar 

Santo RCE, Fernandes KZ, Lora PS, Filippin LI, Xavier RM (2018) Prevalence of rheumatoid cachexia in rheumatoid arthritis: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 9(5):816–825. https://doi.org/10.1002/JCSM.12320

Article  PubMed  PubMed Central  Google Scholar 

Giles JT, Allison M, Blumenthal RS et al (2010) Abdominal adiposity in rheumatoid arthritis: association with cardiometabolic risk factors and disease characteristics. Arthritis Rheum 62(11):3173–3182. https://doi.org/10.1002/ART.27629

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kremers HM, Nicola PJ, Crowson CS, Ballman KV, Gabriel SE (2004) Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis. Arthritis Rheum 50(11):3450–3457. https://doi.org/10.1002/ART.20612

Article  PubMed  Google Scholar 

Summers GD, Metsios GS, Stavropoulos-Kalinoglou A, Kitas GD (2010) Rheumatoid cachexia and cardiovascular disease. Nat Rev Rheumatol 6(8):445–451. https://doi.org/10.1038/NRRHEUM.2010.105

Article  PubMed  Google Scholar 

Lupoli R, Pizzicato P, Scalera A et al (2016) Impact of body weight on the achievement of minimal disease activity in patients with rheumatic diseases: a systematic review and meta-analysis. Arthritis Res Ther 18(1). https://doi.org/10.1186/S13075-016-1194-8

Klaasen R, Wijbrandts CA, Gerlag DM, Tak PP (2011) Body mass index and clinical response to infliximab in rheumatoid arthritis. Arthritis Rheum 63(2):359–364. https://doi.org/10.1002/ART.30136