Systemic inflammation activates coagulation and immune cell infiltration pathways in brains with propagating α-synuclein fibril aggregates

Atp1a2

ATPase Na+/K+ transporting subunit Alpha2

Atp1b2

ATPase Na+/K+ transporting subunit Beta2

Dlat

Mitochondrial dehydrogenase complex

Dlg2

Discs large homolog 2

Dlg4

Discs large homolog 4

GCIs

Glial cytoplasmic inclusions

Homer1

Homer protein homolog 1

Iba1

Ionized calcium-binding adapter molecule 1/Allograft Inflammatory Factor 1

IFN-γ

interferon-(IFN)-γ

KC/GRO

keratinocyte chemoattractant/growth-regulated oncogenes

MSA

Multiple system atrophy

NCIs

Neuronal cytoplasmic inclusions

Ndufs4

NADH-Ubiquinone Oxidoreductase subunit S4

OXPHOS

oxidative phosphorylation

PPI

protein-protein interaction

p-α-syn

phospho-α-synuclein

Slc1a3

Excitatory amino acid transporter 1

Slc25a11

Solute Carrier Family 25 (mitochondrial carrier, oxoglutarate carrier), Member 11

Slc4a4

solute carrier family 4 member 4 protein

Slc6a1

Sodium- and chloride-dependent GABA transporter 1

Slc6a11

Sodium- and chloride-dependent GABA transporter 3

TCEP

Tris(2-carboxyethyl) phosphine

TNFα

tumor necrosis factor-alpha

Uqcrc2

Ubiquinol-Cytochrome-C Reductase Complex Core protein

α-syn

alpha(α)-synuclein

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