Ibanez B et al (2018) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 39(2):119–177

Article  PubMed  Google Scholar 

de Waha S et al (2017) Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials. Eur Heart J 38(47):3502–3510

Article  PubMed  Google Scholar 

Niccoli G et al (2016) Coronary microvascular obstruction in acute myocardial infarction. Eur Heart J 37(13):1024–1033

Article  PubMed  Google Scholar 

Unsicker K, Spittau B, Krieglstein K (2013) The multiple facets of the TGF-beta family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1. Cytokine Growth Factor Rev 24(4):373–384

Article  CAS  PubMed  Google Scholar 

Kempf T et al (2006) The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res 98(3):351–360

Article  CAS  PubMed  Google Scholar 

Kempf T et al (2011) GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med 17(5):581–588

Article  CAS  PubMed  Google Scholar 

Xu J et al (2006) GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res 98(3):342–350

Article  CAS  PubMed  Google Scholar 

Wollert KC, Kempf T, Wallentin L (2017) Growth differentiation factor 15 as a biomarker in cardiovascular disease. Clin Chem 63(1):140–151

Article  CAS  PubMed  Google Scholar 

Li M et al (2020) Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease. Cardiovasc Diabetol 19(1):120

Article  PubMed  PubMed Central  Google Scholar 

Xie S, Lu L, Liu L (2019) Growth differentiation factor-15 and the risk of cardiovascular diseases and all-cause mortality: a meta-analysis of prospective studies. Clin Cardiol 42(5):513–523

Article  PubMed  PubMed Central  Google Scholar 

Wu E et al (2001) Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 357(9249):21–28

Article  CAS  PubMed  Google Scholar 

Ibanez B et al (2019) Cardiac MRI endpoints in myocardial infarction experimental and clinical trials: JACC scientific expert panel. J Am Coll Cardiol 74(2):238–256

Article  PubMed  PubMed Central  Google Scholar 

Symons R et al (2018) Long-term incremental prognostic value of cardiovascular magnetic resonance after ST-segment elevation myocardial infarction: a study of the collaborative registry on CMR in STEMI. JACC Cardiovasc Imaging 11(6):813–825

Article  MathSciNet  PubMed  Google Scholar 

Desquilbet L, Mariotti F (2010) Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 29(9):1037–1057

Article  MathSciNet  PubMed  Google Scholar 

No author (1991) Troponin T and myocardial damage. Lancet 338(8758):23–24

Article  Google Scholar 

Garcia R et al (2019) VEGF-A plasma levels are associated with microvascular obstruction in patients with ST-segment elevation myocardial infarction. Int J Cardiol 291:19–24

Article  PubMed  Google Scholar 

Arcari L et al (2015) Impact of heart rate on myocardial salvage in timely reperfused patients with ST-segment elevation myocardial infarction: new insights from cardiovascular magnetic resonance. PLoS ONE 10(12):e0145495

Article  PubMed  PubMed Central  Google Scholar 

Eitel I et al (2011) Growth-differentiation factor 15 as predictor of mortality in acute reperfused ST-elevation myocardial infarction: insights from cardiovascular magnetic resonance. Heart 97(8):632–640

Article  PubMed  Google Scholar 

Zhang M et al (2016) Growth differentiation factor 15 may protect the myocardium from no-reflow by inhibiting the inflammatory-like response that predominantly involves neutrophil infiltration. Mol Med Rep 13(1):623–632

Article  CAS  PubMed  Google Scholar 

Taddei S, Virdis A (2010) Growth differentiation factor-15 and cardiovascular dysfunction and disease: malefactor or innocent bystander? Eur Heart J 31(10):1168–1171

Article  CAS  PubMed  Google Scholar 

Thiele, H. et al. (2010) Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the LIPSIA-N-ACC (Prospective, single-blind, placebo-controlled, randomized Leipzig Immediate PercutaneouS coronary intervention acute myocardial infarction N-ACC) trial. J Am Coll Cardiol 55(20): 2201–2209

McLeod SL, Iansavichene A, Cheskes S (2017) Remote ischemic Perconditioning to reduce reperfusion injury during acute ST-segment-elevation myocardial infarction: a systematic review and meta-analysis. J Am Heart Assoc. https://doi.org/10.1161/JAHA.117.005522

Article  PubMed  PubMed Central  Google Scholar 

Davidson SM et al (2019) Multitarget strategies to reduce myocardial ischemia/reperfusion injury: JACC review topic of the week. J Am Coll Cardiol 73(1):89–99

Article  PubMed  Google Scholar 

Hausenloy DJ, Yellon DM (2004) New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res 61(3):448–460

Article  CAS  PubMed  Google Scholar 

Wang J et al (2020) Intravenously delivered mesenchymal stem cells prevent microvascular obstruction formation after myocardial ischemia/reperfusion injury. Basic Res Cardiol 115(4):40

Article  CAS  PubMed  Google Scholar 

Artz A, Butz S, Vestweber D (2016) GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-betaRII heterodimer. Blood 128(4):529–541

Article  CAS  PubMed  Google Scholar 

Hayiroglu MI et al (2019) Predictors of in-hospital mortality in patients with ST-segment elevation myocardial infarction complicated with cardiogenic shock. Heart Lung Circ 28(2):237–244

Article  PubMed  Google Scholar 

Cinar T et al (2019) The predictive value of age, creatinine, ejection fraction score for in-hospital mortality in patients with cardiogenic shock. Coron Artery Dis 30(8):569–574

Article  PubMed  Google Scholar