Keywords
Wistar rat and human hepatocytes
L-thyroxine metabolism
Nuclear receptor activation
Thyroxine-glucuro-conjugation
Human relevance
Endocrine disruption
AbbreviationsAhR
Aryl Hydrocarbon Receptor
CAR
Constitutive Androstane Receptor
DIO1
Iodothyronine Deiodinase Type I
ECHA/EFSA
European Chemicals Agency/European Food Safety Authority
MCT8
Monocarboxylate Transporter 8
MIE
Molecular Initiating Event
MRP2
Multi-drug Resistance Protein 2
NTCP
Na + /Taurocholate Cotransporting Polypeptide
OATP
Organic Anion Transporting Polypeptide
PCN
5-Pregnen-3β-ol-20-one-16α‑carbonitrile
PHH
Primary Human Hepatocytes
PRH
Primary Rat Hepatocytes
rT3
3,3′,5′-Triiodo-L-thyronine
T3
3,3′,5-Triiodo-L-thyronine
T4-UGT
T4-UDP-glucuronotransferase
UGT
UDP-glucuronosyltransferase
Data availability
Data will be made available on request.
© 2024 The Authors. Published by Elsevier Ltd.
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