Thrift, A.P. and El-Serag, H.B., Burden of gastric cancer, Clin. Gastroenterol. Hepatol., 2020, vol. 18, no. 3, pp. 534–542.

Article  PubMed  Google Scholar 

Arnold, M., Abnet, C.C., Neale, R.E., et al., Global burden of 5 major types of gastrointestinal cancer, Gastroenterology, 2020, vol. 159, no. 1, pp. 335–349.е315.

Article  PubMed  Google Scholar 

Hamashima, C., The burden of gastric cancer, Ann. Transl. Med., 2020, vol. 8, no. 12, p. 734.

Article  PubMed  PubMed Central  Google Scholar 

Yin, H.L. and Stossel, T.P., Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein, Nature, 1979, vol. 281, no. 5732, pp. 583–586.

Article  CAS  PubMed  ADS  Google Scholar 

McGough, A.M., Staiger, C.J., Min, J.K., et al., The gelsolin family of actin regulatory proteins: modular structures, versatile functions, FEBS Lett., 2003, vol. 552, nos. 2–3, pp. 75–81.

Article  CAS  PubMed  Google Scholar 

Zhuo, J., Tan, E.H., Yan, B., et al., Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade, PLoS One, 2012, vol. 7, no. 8, p. e43594.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Kelley, D.Z., Flam, E.L., Guo, T., et al., Functional characterization of alternatively spliced GSN in head and neck squamous cell carcinoma, Transl. Res., 2018, vol. 202, pp. 109–119.

Article  CAS  PubMed  Google Scholar 

Vivian, J., Rao, A.A., Nothaft, F.A., et al., Toil enables reproducible, open source, big biomedical data analyses, Nat. Biotechnol., 2017, vol. 35, no. 4, pp. 314–316.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandrashekar, D.S., Bashel, B., Balasubramanya, S.A.H., et al., UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses, Neoplasia, 2017, vol. 19, no. 8, pp. 649–658.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uhlén, M., Fagerberg, L., Hallström, B.M., et al., Proteomics: tissue-based map of the human proteome, Science, 2015, vol. 347, no. 6220, p. 1260419.

Article  PubMed  Google Scholar 

Uhlen, M. and Zhang, C., A pathology atlas of the human cancer transcriptome, Science, 2017, vol. 357, no. 6352.

Thul, P.J. and Åkesson, L., A subcellular map of the human proteome, Science, 2017, vol. 356, no. 6340.

Zhang, Q., Xia, T., Qi, C., et al., High expression of S100A2 predicts poor prognosis in patients with endometrial carcinoma, BMC Cancer, 2022, vol. 22, no. 1, p. 77.

Article  PubMed  PubMed Central  Google Scholar 

Xia, S., Lin, Y., Lin, J., et al., Increased expression of TICRR predicts poor clinical outcomes: a potential therapeutic target for papillary renal cell carcinoma, Front. Genet., 2020, vol. 11, p. 605378.

Yu, G., Wang, L.G., Han, Y., et al., clusterProfiler: an R package for comparing biological themes among gene clusters, Omics, 2012, vol. 16, no. 5, pp. 284–287.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng, R., Hao, J., Han, W., et al., Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells, Oncol. Lett., 2015, vol. 9, no. 5, pp. 2129–2134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo, Y., Zhang, H., Xing, X., et al., Gelsolin regulates proliferation, apoptosis and invasion in natural killer/T-cell lymphoma cells, Biol. Open, 2018, vol. 7, no. 1.

Bai, R., Chen, N., Liang, T., et al., Novel frontiers of treatment for advanced gastric or gastroesophageal junction cancer (GC/GEJC): will immunotherapy be a future direction?, Front. Oncol., 2020, vol. 10, p. 912.

Kanda, Y., Kakutani, K., Yurube, T., A novel topical treatment for bone metastases using a gelatin hydrogel incorporating cisplatin as a sustained release system, J. Orthop. Res., 2021, vol. 39, no. 3, pp. 525–535.

Article  CAS  PubMed  Google Scholar 

Li, S., Li, J., Peng, L., et al., Cost-effectiveness of frontline treatment for advanced renal cell carcinoma in the era of immunotherapies, Front. Pharmacol., 2021, vol. 12, p. 718014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan, C., Zhang, E., Huang, L., et al., Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patches, BMC Vet. Res., 2018, vol. 14, no. 1, p. 239.

Article  PubMed  PubMed Central  Google Scholar 

Yuan, C., Zhang, E., Huang, L., et al., Correction to: Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patches, BMC Vet. Res., 2018, vol. 14, no. 1, p. 303.

Article  PubMed  PubMed Central  Google Scholar 

Marino, N., Marshall, J.C., Collins, J.W., et al., Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis, Cancer Res., 2013, vol. 73, no. 19, pp. 5949–5962.

Article  CAS  PubMed  Google Scholar 

Chen, C.C., Chiou, S.H., Yang, C.L., et al., Secreted gelsolin desensitizes and induces apoptosis of infiltrated lymphocytes in prostate cancer, Oncotarget, 2017, vol. 8, no. 44, pp. 77152–77167.

Article  PubMed  PubMed Central  Google Scholar 

Kim, J.C., Ha, Y.J., Tak, K.H., et al., Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively, PLoS One, 2018, vol. 13, no. 8, p. e0202856.

Article  PubMed  PubMed Central  Google Scholar 

Zhu, X., Cai, L., Meng, Q., et al., Gelsolin inhibits the proliferation and invasion of the 786-0 clear cell renal cell carcinoma cell line in vitro, Mol. Med. Rep., 2015, vol. 12, no. 5, pp. 6887–6894.

Article  CAS  PubMed  Google Scholar 

Noske, A., Denkert, C., Schober, H., et al., Loss of gelsolin expression in human ovarian carcinomas, Eur. J. Cancer, 2005, vol. 41, no. 3, pp. 461–469.

Article  CAS  PubMed  Google Scholar 

Silacci, P., Mazzolai, L., Gauci, C., et al., Gelsolin superfamily proteins: key regulators of cellular functions, Cell Mol. Life Sci., 2004, vol. 61, nos. 19–20, pp. 2614–2623.

Article  CAS  PubMed  Google Scholar 

Ma, X., Sun, W., Shen, J., et al., Gelsolin promotes cell growth and invasion through the upregulation of p-AKT and p-P38 pathway in osteosarcoma, Tumour Biol., 2016, vol. 37, no. 6, pp. 7165–7174.

Article  CAS  PubMed  Google Scholar 

Fu, C. and Jiang, A., Dendritic cells and CD8 T cell immunity in tumor microenvironment, Front. Immunol., 2018, vol. 9, p. 3059.

Nie, S. and Yuan, Y., The role of gastric mucosal immunity in gastric diseases, J. Immunol. Res., 2020, vol. 2020, p. 7927054.