Pharmacokinetics and pharmacodynamics of antibacterial peptide NZX in Staphylococcus aureus mastitis mouse model

Andes D, Craig W, Nielsen LA, Kristensen HH (2009) In vivo pharmacodynamic characterization of a novel plectasin antibiotic, NZ2114, in a murine infection model. Antimicrob Agents Chemother 53(7):3003–3009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boix V, Fedorak RN, Mullane KM, Pesant Y, Stoutenburgh U, Jin M, Adedoyin A, Chesnel L, Guris D, Larson KB, Murata Y (2017) Primary outcomes from a phase 3, randomized, double-blind, active-controlled trial of surotomycin in subjects with Clostridium difficile infection. Open Forum Infect Dis 4(1):ofw275

Brinch KS, Sandberg A, Baudoux P, Van Bambeke F, Tulkens PM, Frimodt-Møller N, Høiby N, Kristensen HH (2009) Plectasin shows intracellular activity against Staphylococcus aureus in human Thp-1 monocytes and in a mouse peritonitis model. Antimicrob Agents Chemother 53(11):4801–4808

Brinch KS, Tulkens PM, Van Bambeke F, Frimodt-Møller N, Høiby N, Kristensen HH (2010) Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human Thp-1 monocytes, and comparison with daptomycin and vancomycin. J Antimicrob Chemother 65(8):1720–1724

Buccini DF, Cardoso MH, Franco OL (2021) Antimicrobial peptides and cell-penetrating peptides for treating intracellular bacterial infections. Front Cell Infect Microbiol 10:612931

Article  PubMed  PubMed Central  Google Scholar 

Cheung GYC, Bae JS, Otto M (2021) Pathogenicity and virulence of Staphylococcus aureus. Virulence 12(1):547–569

Craft KM, Nguyen JM, Berg LJ, Townsend SD (2019) Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype. Medchemcomm 10(8):1231–1241

Dorival-García N, Junza A, Zafra-Gómez A, Barrón D, Navalón A (2016) Simultaneous determination of quinolone and β-Lactam residues in raw cow milk samples using ultrasound-assisted extraction and dispersive-SPE prior to UHPLC-Ms/Ms analysis. Food Control 60:382–393

Article  Google Scholar 

Ewles M, Goodwin L (2011) Bioanalytical approaches to analyzing peptides and proteins by LC–Ms/Ms. Bioanalysis 3(12):1379–1397

Article  CAS  PubMed  Google Scholar 

Gorman GS, Coward LU, Freeman L, Noker PE, Beattie CW, Jia L (2010) A novel and rapid LC/MS/MS assay for bioanalysis of azurin P28 in serum and its pharmacokinetics in mice. J Pharm Biomed Anal 53(4):991–996

Article  CAS  PubMed  PubMed Central  Google Scholar 

Günther J, Petzl W, Bauer I, Ponsuksili S, Zerbe H, Schuberth HJ, Brunner RM, Seyfert HM (2017) Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection. Sci Rep 7(1):4811

Guo Y, Song G, Sun M, Wang J, Wang Y (2020) Prevalence and therapies of antibiotic-resistance in Staphylococcus aureus. Front Cell Infect Microbiol 10:107

Han F, Zhang H, Xia X, Xiong H, Song D, Zong X, Wang YZ (2015) Porcine β-Defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis. J Immunol 194(4):1882–1893

Article  CAS  PubMed  Google Scholar 

Hao Y, Wang J, de la Fuente-Nunez C, Franco O (2022) Editorial: antimicrobial peptides: molecular design, structure-function relationship, and biosynthesis optimization. Front Microbiol 13:888540

Article  PubMed  PubMed Central  Google Scholar 

Hao Y, Teng D, Mao R, Yang N, Wang J (2023) Site mutation improves the expression and antimicrobial properties of fungal defense. Antibiotics (basel) 12(8):1283

Article  CAS  PubMed  Google Scholar 

Hoofnagle AN, Wener MH (2009) The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry. J Immunol Methods 347(1–2):3–11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang Y, Chen Y, Song Z, Tan Z, Cheng J (2021) Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation. Adv Drug Deliv Rev 170:261–280

Article  CAS  PubMed  Google Scholar 

Krishnamoorthy P, Suresh KP, Jayamma KS, Shome BR, Patil SS, Amachawadi RG (2021) An understanding of the global status of major bacterial pathogens of milk concerning bovine mastitis: a systematic review and meta-analysis (Scientometrics). Pathogens 10(5):545

Article  PubMed  PubMed Central  Google Scholar 

Lehar SM, Pillow T, Xu M, Staben L, Kajihara KK, Vandlen R, DePalatis L, Raab H, Hazenbos WL, Morisaki JH, Kim J, Park S, Darwish M, Lee BC, Hernandez H, Loyet KM, Lupardus P, Fong R, Yan D, Chalouni C, Luis E, Khalfin Y, Plise E, Cheong J, Lyssikatos JP, Strandh M, Koefoed K, Andersen PS, Flygare JA, Wah Tan M, Brown EJ, Mariathasan S (2015) Novel antibody-antibiotic conjugate eliminates intracellular S. aureus. Nature 527(7578):323–328

Lei Z, Liu Q, Zhu Q, Yang B, Khaliq H, Sun A, Qi Y, Moku GK, Su Y, Wang J, Cao J, He Q (2018) Comparative pharmacokinetics and preliminary pharmacodynamics evaluation of piscidin 1 against PRV and PEDV in rats. Front Chem 6:244

Article  ADS  PubMed  PubMed Central  Google Scholar 

Li L, Wang L, Gao Y, Wang J, Zhao X (2017) Effective antimicrobial activity of plectasin-derived antimicrobial peptides against Staphylococcus aureus infection in mammary glands. Front Microbiol 8:2386

Li B, Yang N, Wang X, Hao Y, Mao R, Li Z, Wang Z, Teng D, Wang J (2020) An enhanced variant designed from DLP4 cationic peptide against Staphylococcus aureus CVCC 546. Front Microbiol 11:1057

Li J, Chen J, Yang G, Tao L (2021) Sublancin protects against methicillin-resistant Staphylococcus aureus infection by the combined modulation of innate immune response and microbiota. Peptides 141:170533

Liu H, Yang N, Mao R, Teng D, Hao Y, Wang X, Wang J (2020) A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in vitro/vivo. Appl Microbiol Biotechnol 104(4):1555–1568

Ma J, Zhao L, Sun D, Zhang J, Guo Y, Zhang Z, Ma Q, Ji C, Zhao L (2020) Effects of dietary supplementation of recombinant plectasin on growth performance, intestinal health and innate immunity response in broilers. Probiotics Antimicrob Proteins 12(1):214–223

Article  CAS  PubMed  Google Scholar 

Mackenzie FM, Gould IM (1993) The post-antibiotic effect. J Antimicrob Chemother 32(4):519–537

Article  CAS  PubMed  Google Scholar 

Muttenthaler M, King GF, Adams DJ, Alewood PF (2021) Trends in peptide drug discovery. Nat Rev Drug Discov 20(4):309–325

Article  CAS  PubMed  Google Scholar 

Nikkhah A, RezaGholivand A, Khabbazan MH (2021) Milk yield depression and its economic loss due to production diseases: Iran’s large dairy herds. Iran J Vet Res 22(2):136–139

CAS  PubMed  PubMed Central  Google Scholar 

Plowgian C, Blondeau JM, Levinson M, Rosenkrantz W (2019) A pilot study on the comparative minimum inhibitory and mutant prevention concentration values for moxifloxacin and pradofloxacin against canine and human isolates of Staphylococcus pseudintermedius and S. schleiferi. Vet Dermatol 30(6):481–e142

Rainard P, Foucras G, Fitzgerald JR, Watts JL, Koop G, Middleton JR (2018) Knowledge gaps and research priorities in Staphylococcus aureus mastitis control. Transbound Emerg Dis 65(Suppl 1):149–165

Ruegg PL (2017) A 100-year review: mastitis detection, management, and prevention. J Dairy Sci 100(12):10381–10397

Article  CAS  PubMed  Google Scholar 

Schmelcher M, Powell AM, Becker SC, Camp MJ, Donovan DM (2012) Chimeric phage lysins act synergistically with lysostaphin to kill mastitis-causing Staphylococcus aureus in murine mammary glands. Appl Environ Microbiol 78(7):2297–2305

Schmidt J, Rattner DW, Lewandrowski K, Compton CC, Mandavilli U, Knoefel WT, Warshawet AL (1992) A better model of acute pancreatitis for evaluating therapy. Ann Surg 215(1):44–56

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidt R, Ostorházi E, Wende E, Knappe D, Hoffmann R (2016) Pharmacokinetics and in vivo efficacy of optimized oncocin derivatives. J Antimicrob Chemother 71(4):1003–1011

Article  CAS  PubMed  Google Scholar 

Sharma S, Khuller G (2001) DNA as the intracellular secondary target for antibacterial action of human neutrophil peptide-I against Mycobacterium tuberculosis H37Ra. Curr Microbiol 43(1):74–76

Sharma H, Nagaraj R (2015) Human β-Defensin 4 with non-native disulfide bridges exhibit antimicrobial activity. PLoS ONE 10(3):e0119525

Article  PubMed  PubMed Central  Google Scholar 

Sharma N, Batoo AS, Huma ZI, Kour S, Jyoti M, Hussain K (2017) Impact of mastitis on reproductive performance in dairy animals: a review. Theriogenology 7(1):41–49

CAS  Google Scholar 

Sieprawska-Lupa M, Mydel P, Krawczyk K, Wójcik K, Puklo M, Lupa B, Suder P, Silberring J, Reed M, Pohl J, Shafer W, McAleese F, Foster T, Travis J, Potempa J (2004) Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother 48(12):4673–4679

Starr CG, He J, Wimley WC (2016) Host cell interactions are a significant barrier to the clinical utility of peptide antibiotics. ACS Chem Biol 11(12):3391–3399

Article  CAS  PubMed  PubMed Central  Google Scholar 

Svenson J, Brandsdal BO, Stensen W, Svendsen JS (2007) Albumin binding of short cationic antimicrobial micropeptides and its influence on the in vitro bactericidal effect. J Med Chem 50(14):3334–3339

Article  CAS  PubMed  Google Scholar 

Tenland E, Krishnan N, Rönnholm A, Kalsum S, Puthia M, Mörgelin M, Davoudi M, Otrocka M, Alaridah N, Glegola-Madejska I, Sturegård E, Schmidtchen A, Lerm M, Robertson BD, Godaly G (2018) A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis. Tuberculosis (edinb) 113:231–238

Vasquez AK, Nydam DV, Capel MB, Eicker S, Virkler PD (2017) Clinical outcome comparison of immediate blanket treatment versus a delayed pathogen-based treatment protocol for clinical mastitis in a new york dairy herd. J Dairy Sci 100(4):2992–3003

Article  CAS  PubMed  Google Scholar 

Wang H, Wu H, Ciofu O, Song Z, Høiby N (2012) In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother 56(5):2683–2690

Wang H, Chen C, Chen X, Zhang J, Liu Y, Li X (2021) PK/PD modeling to assess rifaximin clinical dosage in a mouse model of Staphylococcus aureus-induced mastitis. Front Vet Sci 8:651369

Watts JL, Shryock TR, Apley M, Bade DL, Brown SD, Gray JT, Gray JT, Heine H, Hunter R, Mevius D, Pepich MG, Silley P, Zurenko GE (2013) Performance standards for antimicrobial disk and dilution susceptibility test for bacteria isolated from animals; approved standard. Wayne, PA, National Committee for Clinical Laboratory Standards (NCCLS) VET01-A4

Wu Y, Yang N, Mao R, Hao Y, Teng D, Wang J (2022) In vitro pharmacodynamics and bactericidal mechanism of fungal defensin-derived peptides NZX and P2 against Streptococcus agalactiae. Microorganisms 10(5):881

Xu W, Guan R, Lu Y, Su X, Xu Y, Du A, Hu S (2015) Therapeutic effect of polysaccharide fraction of atractylodis macrocephalae koidz. in bovine subclinical mastitis. BMC Vet Res 11:165

Article  PubMed  PubMed Central  Google Scholar 

Yang N, Teng D, Mao R, Hao Y, Wang X, Wang Z, Wang X, Wang J (2019) A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms. Appl Microbiol Biotechnol 103(13):5193–5213

Yang N, Zhang Q, Mao R, Hao Y, Ma X, Teng D, Fan H, Wang J (2022) Effect of NZ2114 against Streptococcus dysgalactiae biofilms and its application in murine mastitis model. Front Microbiol 13:1010148

Yu Y, Zhou YF, Li X, Chen MR, Qiao GL, Sun J, Liao X, Liu Y (2016) Dose assessment of cefquinome by pharmacokinetic/pharmacodynamic modeling in mouse model of Staphylococcus aureus mastitis. Front Microbiol 7:1595

Zhang Y, Teng D, Mao R, Wang X, Xi D, Hu X, Wang J (2014) High expression of a plectasin-derived peptide NZ2114 in Pichia pastoris and its pharmacodynamics, postantibiotic and synergy against Staphylococcus aureus. Appl Microbiol Biotechnol 98(2):681–694

Zhang M, Ouyang J, Fu L, Xu C, Ge Y, Sun S, Li X, Lai S, Ke H, Yuan B, Yang K, Yu H, Gao L, Yipeng Wang Y (2022) Hydrophobicity determines the bacterial killing rate of α-helical antimicrobial peptides and influences the bacterial resistance development. J Med Chem 65(21):14701–14720

Article  CAS  PubMed  Google Scholar 

Zheng X, Teng D, Mao R, Hao Y, Yang N, Hu F, Wang J (2021) A study on fungal defensin against multidrug-resistant Clostridium perfringens and its treatment on infected poultry. Appl Microbiol Biotechnol 105(19):7265–7282

Zheng X, Yang N, Mao R, Hao Y, Teng D, Wang J (2022) Pharmacokinetics and pharmacodynamics of fungal defensin NZX against Staphylococcus aureus-induced mouse peritonitis model. Front Microbiol 13:865774

Zouharova M, Rysanek D (2008) Multiplex PCR and RPLA identification of Staphylococcus aureus enterotoxigenic strains from bulk tank milk. Zoonoses Public Health 55(6):313–319

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