This communication outlines the use of a General Knowledge Quiz (GKQ) in predicting academic success in higher education. Students’ scores from the GKQ, completed at the start of the academic year, and fall semester exam averages were found to correlated significantly (p = 0.008), demonstrating a link between quiz score and learning outcomes. Moreover, students who averaged below 80% on exams had significantly lower GKQ scores compared to those who achieved passing grades (80–89.9%, p = 0.013; ≥ 89.9%, p = 0.003). This tool can be tailored for early prediction of students who may need additional academic support.