HHV8-positive primary effusion lymphoma assessed by ICC on CB prepared from SurePathTM residue (Case 2, pleural effusion, 84/M). A SurePathTM preparation of the pleural effusion showing dispersed noncohesive large malignant round cells. B No significant lymphadenopathy on CT and PET-CT scans. C SurePathTM residue embedded in a frozen cell block (F-CB) showing tumor cells negative for LCA (CD45), CD3, and CD20 but positive for CD30, CD43, MUM1, and HHV8. ICC, immunocytochemistry; CT, computed tomography; PET, positron emission tomography; CB, cell block; F-CB, frozen CB