Available online 23 January 2024

Dalbergia Odorifera heartwood extract demonstrated noteworthy anti-MRSA activity.

Volatile and non-volatile chemical compositions of extract from different organs of D. Odorifera was systematically identified.

Antibacterial mechanisms were explored by transcriptomic analysis.

D. Odorifera induced adverse effects on RNA synthesis and transcription, and protein translation and involved in inhibiting two-component systems and auxiliary gene regulatory quorum sensing systems.

MD simulation studies were performed to comprehend the binding interactions.

© 2024 The Authors. Published by Elsevier B.V. on behalf of Xi’an Jiaotong University.