A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by Autodisplay-based screening

Journal of Pharmaceutical Analysis

Available online 5 February 2024

Journal of Pharmaceutical AnalysisAuthor links open overlay panel, , , , , , , , , , , , Highlights•

Surface display of ligand binding domains of the NMDA receptor on E. coli

Displaying cells applicable for binding assays to identify novel binders

Fluorescent compound 8 binds to the same binding site as GluN2A selective TCN-201

Compound 8 applicable for staining of recombinant and native NMDA receptors

Compound 8 exhibits selectivity for GluN2A over GluN2B containing receptors

© 2024 The Author(s). Published by Elsevier B.V. on behalf of Xi’an Jiaotong University.

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