Available online 22 February 2024, 104020

PDT is an innovative therapy in treating early-stage EC and has been poorly reported in the literature.

PDT combined with hysteroscopic resection can be a good choice for patients with early-stage EC who want to preserve fertility.

Endometrial carcinoma (EC) is one of the most prevalent gynecological malignancies and the onset age of EC tends to be younger. This case report explored the feasibility of surgery combined with photodynamic therapy (PDT) in two young patients with early-stage EC.

A 31 years old patient and a 24 years old patient were treated with surgery and PDT, respectively. The intraoperative PDT was performed 3 h after oral administration of 5-aminolevulinic acid (ALA) with intrauterine light irradiation of 630 nm laser light.

The patients were followed up for 3 years and 4 months, respectively. There were no signs of recurrence.

Intraoperative and intrauterine PDT was feasible and might be used for EC patients who attempt to preserve fertility.

Endometrial carcinoma

Photodynamic therapy

Fertility preservation

© 2024 Published by Elsevier B.V.