Abdulla S, Machts J, Kaufmann J, Patrick K, Kollewe K, Dengler R, Heinze HJ, Petri S, Vielhaber S, Nestor PJ (2014) Hippocampal degeneration in patients with amyotrophic lateral sclerosis. Neurobiol Aging 35:2639–2645. https://doi.org/10.1016/j.neurobiolaging.2014.05.035

Article  PubMed  Google Scholar 

Abhinav K, Yeh F-C, El-Dokla A, Ferrando LM, Chang Y-F, Lacomis D, Friedlander RM, Fernandez-Miranda JC (2014) Use of diffusion spectrum imaging in preliminary longitudinal evaluation of amyotrophic lateral sclerosis: development of an imaging biomarker. Front Human Neurosci 8:270. https://doi.org/10.3389/fnhum.2014.00270

Article  Google Scholar 

Adachi Y, Sato N, Saito Y, Kimura Y, Nakata Y, Ito K, Kamiya K, Matsuda H, Tsukamoto T, Ogawa M (2015) Usefulness of SWI for the detection of iron in the motor cortex in amyotrophic lateral sclerosis. J Neuroimaging 25:443–451. https://doi.org/10.1111/jon.12127

Article  PubMed  Google Scholar 

Ahmed H, Wallimann R, Haider A, Hosseini V, Gruber S, Robledo M, Nguyen TAN, Herde AM, Iten I, Keller C, Vogel V, Schibli R, Wünsch B, Mu L, Ametamey SM (2021) Preclinical Development of (18)F-OF-NB1 for Imaging GluN2B-Containing N-Methyl-d-Aspartate Receptors and Its Utility as a Biomarker for Amyotrophic Lateral Sclerosis. J Nucl Med 62:259–265. https://doi.org/10.2967/jnumed.120.246785

Article  CAS  PubMed  Google Scholar 

Ahmed RM, Bocchetta M, Todd EG, Tse NY, Devenney EM, Tu S, Caga J, Hodges JR, Halliday GM, Irish M, Kiernan MC, Piguet O, Rohrer JD (2021) Tackling clinical heterogeneity across the amyotrophic lateral sclerosis-frontotemporal dementia spectrum using a transdiagnostic approach. Brain Commun 3. https://doi.org/10.1093/braincomms/fcab257

Alruwaili AR, Pannek K, Coulthard A, Henderson R, Kurniawan ND, McCombe P (2018) A combined tract-based spatial statistics and voxel-based morphometry study of the first MRI scan after diagnosis of amyotrophic lateral sclerosis with subgroup analysis. J Neuroradiol 45:41–48. https://doi.org/10.1016/j.neurad.2017.03.007

Babu S, Hightower BG, Chan J, Zürcher NR, Kivisäkk P, Tseng CJ, Sanders DL, Robichaud A, Banno H, Evora A, Ashokkumar A, Pothier L, Paganoni S, Chew S, Dojillo J, Matsuda K, Gudesblatt M, Berry JD, Cudkowicz ME, Hooker JM, Atassi N (2021) Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial. NeuroImage Clin 30:102672. https://doi.org/10.1016/j.nicl.2021.102672

Article  PubMed  PubMed Central  Google Scholar 

Baek SH, Park J, Kim YH, Seok HY, Oh KW, Kim HJ, Kwon YJ, Sim Y, Tae WS, Kim SH, Kim BJ (2020) Usefulness of diffusion tensor imaging findings as biomarkers for amyotrophic lateral sclerosis. Sci Rep 10:5199. https://doi.org/10.1038/s41598-020-62049-0

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Bao Y, Chen Y, Piao S, Hu B, Yang L, Li H, Geng D, Li Y (2023) Iron quantitative analysis of motor combined with bulbar region in M1 cortex may improve diagnosis performance in ALS. Eur Radiol 33:1132–1142. https://doi.org/10.1007/s00330-022-09045-2

Article  PubMed  Google Scholar 

Bao Y, Yang L, Chen Y, Zhang B, Li H, Tang W, Geng D, Li Y (2018) Radial diffusivity as an imaging biomarker for early diagnosis of non-demented amyotrophic lateral sclerosis. Eur Radiol 28:4940–4948. https://doi.org/10.1007/s00330-018-5506-z

Article  PubMed  Google Scholar 

Barry RL, Torrado-Carvajal A, Kirsch JE, Arabasz GE, Albrecht DS, Alshelh Z, Pijanowski O, Lewis AJ, Keegan M, Reynolds B, Knight PC, Morrissey EJ, Loggia ML, Atassi N, Hooker JM, Babu S (2022) Selective atrophy of the cervical enlargement in whole spinal cord MRI of amyotrophic lateral sclerosis. NeuroImage Clin 36:103199. https://doi.org/10.1016/j.nicl.2022.103199

Article  PubMed  PubMed Central  Google Scholar 

Bayer D, Antonucci S, Müller HP, Saad R, Dupuis L, Rasche V, Böckers TM, Ludolph AC, Kassubek J, Roselli F (2021) Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients. Trans Neurodegeneration 10:17. https://doi.org/10.1186/s40035-021-00241-6

Article  Google Scholar 

Behler A, Müller HP, Ludolph AC, Kassubek J (2023) Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis: Machine Learning for Biomarker Development. Int J Mol Sci 24. https://doi.org/10.3390/ijms24031911

Behler A, Müller HP, Ludolph AC, Lulé D, Kassubek J (2022) A multivariate Bayesian classification algorithm for cerebral stage prediction by diffusion tensor imaging in amyotrophic lateral sclerosis. NeuroImage Clin 35:103094. https://doi.org/10.1016/j.nicl.2022.103094

Article  PubMed  PubMed Central  Google Scholar 

Bharti K, Khan M, Beaulieu C, Graham SJ, Briemberg H, Frayne R, Genge A, Korngut L, Zinman L, Kalra S (2020) Involvement of the dentate nucleus in the pathophysiology of amyotrophic lateral sclerosis: a multi-center and multi-modal neuroimaging study. NeuroImage Clin 28:102385. https://doi.org/10.1016/j.nicl.2020.102385

Article  PubMed  PubMed Central  Google Scholar 

Bhattarai A, Chen Z, Ward PGD, Talman P, Mathers S, Phan TG, Chapman C, Howe J, Lee S, Lie Y, Egan GF, Chua P (2020) Serial assessment of iron in the motor cortex in limb-onset amyotrophic lateral sclerosis using quantitative susceptibility mapping. Quantitative imaging in medicine and surgery 10:1465–1476. https://doi.org/10.21037/qims-20-187

Bhattarai A, Egan GF, Talman P, Chua P, Chen Z (2022) Magnetic resonance iron imaging in amyotrophic lateral sclerosis. J Magn Reson Imaging 55:1283–1300. https://doi.org/10.1002/jmri.27530

Article  PubMed  Google Scholar 

Braak H, Brettschneider J, Ludolph AC, Lee VM, Trojanowski JQ, Tredici KD (2013) Amyotrophic lateral sclerosis—a model of corticofugal axonal spread. Nat Rev Neurol 9:708–714. https://doi.org/10.1038/nrneurol.2013.221

Article  CAS  PubMed  PubMed Central  Google Scholar 

Broad RJ, Gabel MC, Dowell NG, Schwartzman DJ, Seth AK, Zhang H, Alexander DC, Cercignani M, Leigh PN (2019) Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS. J Neurol Neurosurg Psychiatry 90:404–411. https://doi.org/10.1136/jnnp-2018-318830

Article  PubMed  Google Scholar 

Bueno APA, Pinaya WHL, Moura LM, Bertoux M, Radakovic R, Kiernan MC, Teixeira AL, de Souza LC, Hornberger M, Sato JR (2018) Structural and functional papez circuit integrity in amyotrophic lateral sclerosis. Brain Imaging Behav 12:1622–1630. https://doi.org/10.1007/s11682-018-9825-0

Article  PubMed  Google Scholar 

Caldwell S, Rothman DL (2021) (1)H Magnetic resonance spectroscopy to understand the biological basis of ALS, diagnose patients earlier, and monitor disease progression. Front Neurol 12:701170. https://doi.org/10.3389/fneur.2021.701170

Article  PubMed  PubMed Central  Google Scholar 

Calvo A, Canosa A, Moglia C, Manera U, Grassano M, Vasta R, Palumbo F, Cugnasco P, Gallone S, Brunetti M, De Marchi F, Arena V, Pagani M, Dalgard C, Scholz SW, Chia R, Corrado L, Dalfonso S, Mazzini L, Traynor BJ, Chio A (2022) Clinical and metabolic signature of UNC13A rs12608932 variant in amyotrophic lateral sclerosis. Neurol Genet 8:e200033. https://doi.org/10.1212/nxg.0000000000200033

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canna A, Trojsi F, Di Nardo F, Caiazzo G, Tedeschi G, Cirillo M, Esposito F (2021) Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases. Ann Clin Transl Neurol 8:1774–1785. https://doi.org/10.1002/acn3.51418

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canosa A, Calvo A, Moglia C, Manera U, Vasta R, Di Pede F, Cabras S, Nardo D, Arena V, Grassano M, D’Ovidio F, Van Laere K, Van Damme P, Pagani M, Chiò A (2021) Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a (18)F-2-fluoro-2-deoxy-D-glucose-positron emission tomography study. Eur J Nucl Med Mol Imaging 48:1124–1133. https://doi.org/10.1007/s00259-020-05053-w

Article  PubMed  Google Scholar 

Canosa A, Calvo A, Moglia C, Vasta R, Palumbo F, Solero L, Di Pede F, Cabras S, Arena V, Zocco G, Casale F, Brunetti M, Sbaiz L, Gallone S, Grassano M, Manera U, Pagani M, Chiò A (2022) Amyotrophic lateral sclerosis with SOD1 mutations shows distinct brain metabolic changes. Eur J Nucl Med Mol Imaging 49:2242–2250. https://doi.org/10.1007/s00259-021-05668-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canosa A, Martino A, Giuliani A, Moglia C, Vasta R, Grassano M, Palumbo F, Cabras S, Di Pede F, De Mattei F, Matteoni E, Polverari G, Manera U, Calvo A, Pagani M, Chiò A (2023) Brain metabolic differences between pure bulbar and pure spinal ALS: a 2-[(18)F]FDG-PET study. J Neurol 270:953–959. https://doi.org/10.1007/s00415-022-11445-9

Article  CAS  PubMed  Google Scholar 

Canosa A, Martino A, Manera U, Vasta R, Grassano M, Palumbo F, Cabras S, Di Pede F, Arena V, Moglia C, Giuliani A, Calvo A, Chiò A, Pagani M (2023) Role of brain 2-[(18)F]fluoro-2-deoxy-D-glucose-positron-emission tomography as survival predictor in amyotrophic lateral sclerosis. Eur J Nucl Med Mol Imaging 50:784–791. https://doi.org/10.1007/s00259-022-05987-3

Article  CAS  PubMed  Google Scholar 

Canosa A, Palumbo F, Iazzolino B, Peotta L, Di Pede F, Manera U, Vasta R, Grassano M, Solero L, Arena V, Moglia C, Calvo A, Chiò A, Pagani M (2021) The interplay among education, brain metabolism, and cognitive impairment suggests a role of cognitive reserve in Amyotrophic Lateral Sclerosis. Neurobiol Aging 98:205–213. https://doi.org/10.1016/j.neurobiolaging.2020.11.010

Article  CAS  PubMed  Google Scholar 

Canosa A, Vacchiano V, D’Ovidio F, Calvo A, Moglia C, Manera U, Vasta R, Liguori R, Arena V, Grassano M, Palumbo F, Peotta L, Iazzolino B, Pagani M, Chiò A (2021) Brain metabolic correlates of apathy in amyotrophic lateral sclerosis: an 18F-FDG-positron emission tomography stud. Eur J Neurol 28:745–753. https://doi.org/10.1111/ene.14637

Article  PubMed  Google Scholar 

Cervo A, Cocozza S, Saccà F, Giorgio S, Morra VB, Tedeschi E, Marsili A, Vacca G, Palma V, Brunetti A, Quarantelli M (2015) The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis. Eur J Radiol 84:151–157. https://doi.org/10.1016/j.ejrad.2014.10.019

Article  PubMed  Google Scholar 

Chen HJ, Zhan C, Cai LM, Lin JH, Zhou MX, Zou ZY, Yao XF, Lin YJ (2021) White matter microstructural impairments in amyotrophic lateral sclerosis: a mean apparent propagator MRI study. NeuroImage Clinical 32:102863. https://doi.org/10.1016/j.nicl.2021.102863

Article  PubMed  PubMed Central  Google Scholar 

Chenji S, Ishaque A, Mah D, Fujiwara E, Beaulieu C, Seres P, Graham SJ, Frayne R, Zinman L, Genge A, Korngut L, Johnston W, Kalra S (2021) Neuroanatomical associations of the Edinburgh cognitive and Behavioural ALS screen (ECAS). Brain Imaging Behav 15:1641–1654. https://doi.org/10.1007/s11682-020-00359-7

Article  PubMed  Google Scholar 

Chipika RH, Christidi F, Finegan E, Li Hi Shing S, McKenna MC, Chang KM, Karavasilis E, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, Bede P (2020) Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis. J Neurol Sci 417. https://doi.org/10.1016/j.jns.2020.117039

Christidi F, Argyropoulos GD, Karavasilis E, Velonakis G, Zouvelou V, Kourtesis P, Pantoleon V, Tan EL, Daponte A, Aristeidou S, Xirou S, Ferentinos P, Evdokimidis I, Rentzos M, Seimenis I, Bede P (2023) Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study. Life (Ba