Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chetelat G, Teunissen CE, Cummings J, van der Flier WM (2021) Alzheimer’s disease. Lancet 397:1577–1590
Article CAS PubMed PubMed Central Google Scholar
Hansson O (2021) Biomarkers for neurodegenerative diseases. Nat Med 27:954–963
Article CAS PubMed Google Scholar
Hardy JA, Higgins GA (1992) Alzheimer’s disease: the amyloid cascade hypothesis. Science 256:184–185
Article CAS PubMed ADS Google Scholar
Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R, Contributors (2018) NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement 14:535–562
Article PubMed PubMed Central Google Scholar
Hampel H, Cummings J, Blennow K, Gao P, Jack CR Jr, Vergallo A (2021) Developing the ATX(N) classification for use across the Alzheimer disease continuum. Nat Rev Neurol 17:580–589
Altomare D, de Wilde A, Ossenkoppele R, Pelkmans W, Bouwman F, Groot C, van Maurik I, Zwan M, Yaqub M, Barkhof F, van Berckel BN, Teunissen CE, Frisoni GB, Scheltens P, van der Flier WM (2019) Applying the ATN scheme in a memory clinic population: the ABIDE project. Neurology 93:e1635–e1646
Burnham SC, Coloma PM, Li QX, Collins S, Savage G, Laws S, Doecke J, Maruff P, Martins RN, Ames D, Rowe CC, Masters CL, Villemagne VL (2019) Application of the NIA-AA research framework: towards a biological definition of Alzheimer’s disease using cerebrospinal fluid biomarkers in the AIBL study. J Prev Alzheimers Dis 6:248–255
Dodich A, Mendes A, Assal F, Chicherio C, Rakotomiaramanana B, Andryszak P, Festari C, Ribaldi F, Scheffler M, Schibli R, Schwarz AJ, Zekry D, Lovblad KO, Boccardi M, Unschuld PG, Gold G, Frisoni GB, Garibotto V (2020) The A/T/N model applied through imaging biomarkers in a memory clinic. Eur J Nucl Med Mol Imaging 47:247–255
Article CAS PubMed Google Scholar
Jack CR Jr, Wiste HJ, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Lowe VJ, Vemuri P, Machulda MM, Schwarz CG, Gunter JL, Senjem ML, Graff-Radford J, Jones DT, Roberts RO, Rocca WA, Petersen RC (2019) Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia. JAMA 321:2316–2325
Article CAS PubMed PubMed Central Google Scholar
Kasuga K, Tsukie T, Kikuchi M, Tokutake T, Washiyama K, Shimizu S, Yoshizawa H, Kuroha Y, Yajima R, Mori H, Arakawa Y, Onda K, Miyashita A, Onodera O, Iwatsubo T, Ikeuchi T, Japanese Alzheimer’s Disease Neuroimaging I (2023) The clinical application of optimized AT(N) classification in Alzheimer’s clinical syndrome (ACS) and non-ACS conditions. Neurobiol Aging 127:23–32
Article CAS PubMed Google Scholar
Pascoal TA, Leuzy A, Therriault J, Chamoun M, Lussier F, Tissot C, Strandberg O, Palmqvist S, Stomrud E, Ferreira PCL, Ferrari-Souza JP, Smith R, Benedet AL, Gauthier S, Hansson O, Rosa-Neto P (2023) Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer’s disease. Alzheimers Dement (Amst) 15:e12390
Article PubMed PubMed Central Google Scholar
Peretti DE, Ribaldi F, Scheffler M, Chicherio C, Frisoni GB, Garibotto V (2023) Prognostic value of imaging-based ATN profiles in a memory clinic cohort. Eur J Nucl Med Mol Imaging 50(11):3313–3323
Article PubMed PubMed Central Google Scholar
Therriault J, Gauthier S, Rosa-Neto P (2023) Adding the topographical information from Tau-PET to the A/T/(N) framework: steps towards staging AD in vivo. J Prev Alzheimers Dis 10:381–386
Wang ZB, Tan L, Gao PY, Ma YH, Fu Y, Sun Y, Yu JT, Alzheimer’s Disease Neuroimaging I (2023) Associations of the A/T/N profiles in PET, CSF, and plasma biomarkers with Alzheimer’s disease neuropathology at autopsy. Alzheimers Dement 19(10):4421–4435
Article CAS PubMed Google Scholar
Erickson P, Simren J, Brum WS, Ennis GE, Kollmorgen G, Suridjan I, Langhough R, Jonaitis EM, Van Hulle CA, Betthauser TJ, Carlsson CM, Asthana S, Ashton NJ, Johnson SC, Shaw LM, Blennow K, Andreasson U, Bendlin BB, Zetterberg H, Cohort A (2023) Prevalence and clinical implications of a beta-amyloid-negative, tau-positive cerebrospinal fluid biomarker profile in Alzheimer disease. JAMA Neurol 80(9):969–979
Article PubMed PubMed Central Google Scholar
Ebenau JL, Timmers T, Wesselman LMP, Verberk IMW, Verfaillie SCJ, Slot RER, van Harten AC, Teunissen CE, Barkhof F, van den Bosch KA, van Leeuwenstijn M, Tomassen J, Braber AD, Visser PJ, Prins ND, Sikkes SAM, Scheltens P, van Berckel BNM, van der Flier WM (2020) ATN classification and clinical progression in subjective cognitive decline: the SCIENCe project. Neurology 95:e46–e58
Article CAS PubMed PubMed Central Google Scholar
Oberstein TJ, Schmidt MA, Florvaag A, Haas AL, Siegmann EM, Olm P, Utz J, Spitzer P, Doerfler A, Lewczuk P, Kornhuber J, Maler JM (2022) Amyloid-beta levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy. Brain 145:4032–4041
Article PubMed PubMed Central Google Scholar
Budd Haeberlein S, Aisen PS, Barkhof F, Chalkias S, Chen T, Cohen S, Dent G, Hansson O, Harrison K, von Hehn C, Iwatsubo T, Mallinckrodt C, Mummery CJ, Muralidharan KK, Nestorov I, Nisenbaum L, Rajagovindan R, Skordos L, Tian Y, van Dyck CH, Vellas B, Wu S, Zhu Y, Sandrock A (2022) Two randomized phase 3 studies of aducanumab in early Alzheimer’s disease. J Prev Alzheimers Dis 9:197–210
Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J, Wessels AM, Shcherbinin S, Wang H, Monkul Nery ES, Collins EC, Solomon P, Salloway S, Apostolova LG, Hansson O, Ritchie C, Brooks DA, Mintun M, Skovronsky DM, Investigators T-A (2023) Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial. JAMA 330(6):512–527
Article CAS PubMed PubMed Central Google Scholar
van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, Kanekiyo M, Li D, Reyderman L, Cohen S, Froelich L, Katayama S, Sabbagh M, Vellas B, Watson D, Dhadda S, Irizarry M, Kramer LD, Iwatsubo T (2023) Lecanemab in early Alzheimer’s disease. N Engl J Med 388:9–21
Padovani A, Caratozzolo S, Rozzini L, Pilotto A, Benussi A, Tedeschi G (2022) “Real-world” eligibility for aducanumab depends on clinical setting and patients’ journey. J Am Geriatr Soc 70:626–628
Canevelli M, Rossi PD, Astrone P, Consorti E, Vanacore N, Cesari M (2021) “Real world” eligibility for aducanumab. J Am Geriatr Soc 69:2995–2998
Epelbaum S, Paquet C, Hugon J, Dumurgier J, Wallon D, Hannequin D, Jonveaux T, Besozzi A, Pouponneau S, Hommet C, Blanc F, Berly L, Julian A, Paccalin M, Pasquier F, Bellet J, Boutoleau-Bretonniere C, Charriau T, Rouaud O, Madec O, Mouton A, David R, Bekadar S, Fabre R, Liegey E, Deberdt W, Robert P, Dubois B (2019) How many patients are eligible for disease-modifying treatment in Alzheimer’s disease? A French national observational study over 5 years. BMJ Open 9:e029663
Article PubMed PubMed Central Google Scholar
American Psychiatric Association (2022) Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). American Psychiatric Association Publishin, Washington, DC, US
Pasquier F, Leys D, Weerts JG, Mounier-Vehier F, Barkhof F, Scheltens P (1996) Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts. Eur Neurol 36:268–272
Article CAS PubMed Google Scholar
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 149:351–356
Article CAS PubMed Google Scholar
Davies RR, Kipps CM, Mitchell J, Kril JJ, Halliday GM, Hodges JR (2006) Progression in frontotemporal dementia: identifying a benign behavioral variant by magnetic resonance imaging. Arch Neurol 63:1627–1631
Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J (1992) Atrophy of medial temporal lobes on MRI in “probable” Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 55:967–972
Article CAS PubMed PubMed Central Google Scholar
Koedam EL, Lehmann M, van der Flier WM, Scheltens P, Pijnenburg YA, Fox N, Barkhof F, Wattjes MP (2011) Visual assessment of posterior atrophy development of a MRI rating scale. Eur Radiol 21:2618–2625
Article PubMed PubMed Central Google Scholar
Caminiti SP, Sala A, Presotto L, Chincarini A, Sestini S, Perani D, Alzheimer’s Disease Neuroimaging Initiative ftAIMNdTANS-Gc, Schillaci O, Berti V, Calcagni ML, Cistaro A, Morbelli S, Nobili F, Pappata S, Volterrani D, Gobbo CL (2021) Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps. Eur J Nucl Med Mol Imaging 48:2486–2499
Article CAS PubMed Google Scholar
Cummings J, Apostolova L, Rabinovici GD, Atri A, Aisen P, Greenberg S, Hendrix S, Selkoe D, Weiner M, Petersen RC, Salloway S (2023) Lecanemab: appropriate use recommendations. J Prev Alzheimers Dis 10:362–377
CAS PubMed PubMed Central Google Scholar
Cummings J, Rabinovici GD, Atri A, Aisen P, Apostolova LG, Hendrix S, Sabbagh M, Selkoe D, Weiner M, Salloway S (2022) Aducanumab: appropriate use recommendations update. J Prev Alzheimers Dis 9:221–230
CAS PubMed PubMed Central Google Scholar
Rosenberg A, Ohlund-Wistbacka U, Hall A, Bonnard A, Hagman G, Ryden M, Thunborg C, Wiggenraad F, Sandebring-Matton A, Solomon A, Kivipelto M (2022) beta-Amyloid, Tau, neurodegeneration classification and eligibility for anti-amyloid treatment in a memory clinic population. Neurology 99:e2102–e2113
留言 (0)