Mantegazza R, Wolfe GI, Muppidi S, Wiendl H, Fujita KP, O’Brien FL, Booth HDE, Howard Jr JF, REGAIN Study Group (2021) Post-intervention status in patients with refractory myasthenia gravis treated with eculizumab during REGAIN and its open-label extension. Neurology 96:e610–e618. https://doi.org/10.1212/WNL.0000000000011207
Utsugisawa K, Nagane Y, Akaishi T, Suzuki Y, Imai T, Tsuda E, Minami N, Uzawa A, Kawaguchi N, Masuda M, Konno S, Suzuki H, Murai H, Aoki M (2017) Early fast-acting treatment strategy generalized myasthenia gravis. Muscle Nerve 55:794–801. https://doi.org/10.1002/mus.253973
Article PubMed PubMed Central Google Scholar
Howard JF (2018) Myasthenia gravis: the role of complement at the neuromuscular junction. Ann N Y Acad Sci 1412:113–128. https://doi.org/10.1111/nyas.13522
Article ADS CAS PubMed Google Scholar
Dhillon S (2018) Eculizumab: a review in generalized myasthenia gravis Mar. Drugs 78:367–376. https://doi.org/10.1007/s40265-018-0875-9
Article CAS PubMed PubMed Central Google Scholar
Howard JF, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O’Brien F, Wang JJ, Mantegazza R, REGAIN study group (2017) Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study. Lancet Neurol 16:976–987. https://doi.org/10.1016/S1474-4422(17)30369-1
Yanagidaira M, Nishida Y, Yokota T (2020) Temporal correlation between serum CH50 level and symptom severity of myasthenia gravis during eculizumab therapy. Clin Neurol Neurosurg 189:105630. https://doi.org/10.1016/j.clineuro.2019.105630
Howard JF, Karam C, Yountz M, O’Brien FL, Mozaffar T for the REGAIN Study Group (2021) Long-term efficacy of eculizumab in refractory generalized myasthenia gravis: responder analyses. Ann Clin Transl Neurol 8:1398–1407. https://doi.org/10.1002/acn3.51376
Usman U, Chrisman C, Houston D, Haws CC, Wang A, Muley S (2021) The use of eculizumab in ventilator-dependent myasthenia gravis patients. Muscle Nerve 64:212–215. https://doi.org/10.1002/mus.27326
Article CAS PubMed Google Scholar
Akaaboune M, Culican SM, Turney SG, Lichtman JW (1999) Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science 286:503–507. https://doi.org/10.1126/science.286.5439.503
Article CAS PubMed Google Scholar
Bruneau EG, Macpherson PC, Goldman D, Hume RI, Akaaboune M (2005) The effect of agrin and laminin on acetylcholine receptor dynamics in vitro. Dev Biol 288:248–258. https://doi.org/10.1016/j.ydbio.2005.09.041
Article CAS PubMed Google Scholar
Pham MC, Masi G, Patzina R, Obaid AH, Oxendine SR, Oh S, Payne AS, Nowak RJ, O’Connor KC (2023) Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology. Acta Neuropathol 146:319–336. https://doi.org/10.1007/s00401-023-02603-y
Article CAS PubMed Google Scholar
Maurer M, Bougoin S, Feferman T, Frenkian M, Bismuth J, Mouly V, Clairac G, Tzartos S, Fadel E, Eymard B, Fuchs S, Souroujon MC, Berrih-Aknin S (2015) IL-6 and Akt are involved in muscular pathogenesis in myasthenia gravis. Acta Neuropathol Commun 3:1. https://doi.org/10.1186/s40478-014-0179-6
Article CAS PubMed PubMed Central Google Scholar
Tüzün E, Huda R, Christadoss P (2011) Complement and cytokine based therapeutic strategies in myasthenia gravis. J Autoimmun 37:136–143. https://doi.org/10.1016/j.jaut.2011.05.006
Article CAS PubMed Google Scholar
Molin CJ, Westerberg E, Punga AR (2017) Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients. Sci Rep 7:39716. https://doi.org/10.1038/srep39716
Article ADS CAS PubMed PubMed Central Google Scholar
Vilquin JT, Bayer AC, Le Panse R, Berrih-Aknin S (2019) The muscle is not a passive target in myasthenia gravis. Front Neurol 10:1343. https://doi.org/10.3389/fneur.2019.01343
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