Agricultural activities and risk of Alzheimer’s disease: the TRACTOR project, a nationwide retrospective cohort study

Angelopoulou E, Paudel YN, Papageorgiou SG, Piperi C. APOE genotype and Alzheimer’s disease: the influence of lifestyle and environmental factors. ACS Chem Neurosci. 2021;12(15):2749–64. https://doi.org/10.1021/acschemneuro.1c00295.

Article  CAS  PubMed  Google Scholar 

Brenowitz WD, Xiang Y, McEvoy CT, et al. Current Alzheimer disease research highlights: evidence for novel risk factors. Chin Med J (Engl). 2021;134(18):2150–9. https://doi.org/10.1097/cm9.0000000000001706.

Article  CAS  PubMed  Google Scholar 

Lopez-Ortiz S, Pinto-Fraga J, Valenzuela P, et al. Physical exercise and Alzheimer’s disease: effects on pathophysiological molecular pathways of the disease. Int J Mol Sci. 2021;22(6):2897. https://doi.org/10.3390/ijms22062897.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vasefi M, Ghaboolian-Zare E, Abedelwahab H, Osu A. Environmental toxins and Alzheimer’s disease progression. Neurochem Int. 2020;141:104852. https://doi.org/10.1016/j.neuint.2020.104852.

Article  CAS  PubMed  Google Scholar 

Breijyeh Z, Karaman R. Comprehensive review on Alzheimer’s disease: causes and treatment. Molecules. 2020;25(24):5789. https://doi.org/10.3390/molecules25245789.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang XX, Tian Y, Wang ZT, Ma YH, Yu JT. The epidemiology of Alzheimer’s disease modifiable risk factors and prevention. J Prev Alzheimers Dis. 2021;8(3):313–21. https://doi.org/10.14283/jpad.2021.15.

Article  PubMed  Google Scholar 

Litke R, Garcharna LC, Jiwani S, Neugroschl J. Modifiable risk factors in Alzheimer disease and related dementias: a review. Clin Ther. 2021;43(6):953–65. https://doi.org/10.1016/j.clinthera.2021.05.006.

Article  PubMed  PubMed Central  Google Scholar 

Ranson JM, Rittman T, Hayat S, et al. Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6. Alzheimers Res Ther. 2021;13(1):169. https://doi.org/10.1186/s13195-021-00895-4.

Article  PubMed  PubMed Central  Google Scholar 

Aloizou AM, Siokas V, Vogiatzi C, et al. Pesticides, cognitive functions and dementia: a review. Toxicol Lett. 2020;326:31–51. https://doi.org/10.1016/j.toxlet.2020.03.005.

Article  CAS  PubMed  Google Scholar 

Baltazar MT, Dinis-Oliveira RJ, de Lourdes BM, Tsatsakis AM, Duarte JA, Carvalho F. Pesticides exposure as etiological factors of Parkinson’s disease and other neurodegenerative diseases: a mechanistic approach. Toxicol Lett. 2014;230(2):85–103. https://doi.org/10.1016/j.toxlet.2014.01.039.

Article  CAS  PubMed  Google Scholar 

Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol. 2011;10(9):819–28. https://doi.org/10.1016/s1474-4422(11)70072-2.

Article  PubMed  PubMed Central  Google Scholar 

Gupta R, Khan R, Cortes CJ. Forgot to exercise? Exercise derived circulating myokines in Alzheimer’s disease: a perspective. Front Neurol. 2021;12:649452. https://doi.org/10.3389/fneur.2021.649452.

Article  PubMed  PubMed Central  Google Scholar 

Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B. Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Front Cell Neurosci. 2015;9:124. https://doi.org/10.3389/fncel.2015.00124.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iqubal A, Ahmed M, Ahmad S, Sahoo CR, Iqubal MK, Haque SE. Environmental neurotoxic pollutants: review. Environ Sci Pollut Res Int. 2020;27(33):41175–98. https://doi.org/10.1007/s11356-020-10539-z.

Article  CAS  PubMed  Google Scholar 

Islam F, Shohag S, Akhter S, et al. Exposure of metal toxicity in Alzheimer’s disease: an extensive review. Front Pharmacol. 2022;13:903099. https://doi.org/10.3389/fphar.2022.903099.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mir RH, Sawhney G, Pottoo FH, et al. Role of environmental pollutants in Alzheimer’s disease: a review. Environ Sci Pollut Res Int. 2020;27(36):44724–42. https://doi.org/10.1007/s11356-020-09964-x.

Article  PubMed  Google Scholar 

Rahman MA, Rahman MS, Uddin MJ, Mamum-Or-Rashid ANM, Pang MG, Rhim H. Emerging risk of environmental factors: insight mechanisms of Alzheimer’s diseases. Environ Sci Pollut Res Int. 2020;27(36):44659–72. https://doi.org/10.1007/s11356-020-08243-z.

Article  PubMed  Google Scholar 

Rahman MA, Hannan MA, Uddin MJ, Rahman MS, Rashid MM, Kim B. Exposure to environmental arsenic and emerging risk of Alzheimer’s disease: perspective mechanisms, management strategy, and future directions. Toxics. 2021;9(8):188. https://doi.org/10.3390/toxics9080188.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rajendran R, Ragavan RP, Al-Sehemi AG, Uddin MS, Aleya L, Mathew B. Current understandings and perspectives of petroleum hydrocarbons in Alzheimer’s disease and Parkinson’s disease: a global concern. Environ Sci Pollut Res Int. 2022;29(8):10928–49. https://doi.org/10.1007/s11356-021-17931-3.

Article  PubMed  Google Scholar 

Syeda T, Cannon JR. Environmental exposures and the etiopathogenesis of Alzheimer’s disease: the potential role of BACE1 as a critical neurotoxic target. J Biochem Mol Toxicol. 2021;35(4):e22694. https://doi.org/10.1002/jbt.22694.

Article  CAS  PubMed  Google Scholar 

Tang BL. Neuropathological mechanisms associated with pesticides in Alzheimer’s disease. Toxics. 2020;8(2):21. https://doi.org/10.3390/toxics8020021.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanner CM, Goldman SM, Webster Ross G, Grate SJ. The disease intersection of susceptibility and exposure: chemical exposures and neurodegenerative disease risk. Alzheimers Dement. 2014;10(3 Suppl):S213–25. https://doi.org/10.1016/j.jalz.2014.04.014.

Article  PubMed  Google Scholar 

Yan D, Zhang Y, Liu L, Yan H. Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis. Sci Rep. 2016;6:32222. https://doi.org/10.1038/srep32222.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yegambaram M, Manivannan B, Beach TG, Halden RU. Role of environmental contaminants in the etiology of Alzheimer’s disease: a review. Curr Alzheimer Res. 2015;12(2):116–46. https://doi.org/10.2174/1567205012666150204121719.

Article  CAS  PubMed  Google Scholar 

Elonheimo HM, Andersen HR, Katsonouri A, Tolonen H. Environmental substances associated with Alzheimer’s disease: a scoping review. Int J Environ Res Public Health. 2021;18(22):11839. https://doi.org/10.3390/ijerph182211839.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gunnarsson LG, Bodin L. Occupational exposures and neurodegenerative diseases-a systematic literature review and meta-analyses. Int J Environ Res Public Health. 2019;16(3):337. https://doi.org/10.3390/ijerph16030337.

Article  PubMed  PubMed Central  Google Scholar 

Hernandez AF, Gonzalez-Alzaga B, Lopez-Flores I, Lacasana M. Systematic reviews on neurodevelopmental and neurodegenerative disorders linked to pesticide exposure: methodological features and impact on risk assessment. Environ Int. 2016;92–93:657–79. https://doi.org/10.1016/j.envint.2016.01.020.

Article  CAS  PubMed  Google Scholar 

Santibanez M, Bolumar F, Garcia AM. Occupational risk factors in Alzheimer’s disease: a review assessing the quality of published epidemiological studies. Occup Environ Med. 2007;64(11):723–32. https://doi.org/10.1136/oem.2006.028209.

Article  PubMed  PubMed Central  Google Scholar 

Zaganas I, Kapetanaki S, Mastorodemos V, et al. Linking pesticide exposure and dementia: What is the evidence? Toxicology. 2013;307:3–11. https://doi.org/10.1016/j.tox.2013.02.002.

Article  CAS  PubMed  Google Scholar 

Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Front Biosci. 2008;13:1240–9. https://doi.org/10.2741/2758.

Article  CAS  PubMed  Google Scholar 

Li Y, Fang R, Liu Z, et al. The association between toxic pesticide environmental exposure and Alzheimer’s disease: a scientometric and visualization analysis. Chemosphere. 2021;263:128238. https://doi.org/10.1016/j.chemosphere.2020.128238.

Article  CAS  PubMed  Google Scholar 

Yadav SS, Singh MN, Yadav RS. Organophosphates induced Alzheimer’s disease: an epigenetic aspect. J Clin Epigenet. 2016;2:1. https://doi.org/10.21767/2472-1158.100010.

Article  Google Scholar 

Gottesman RF, Schneider ALC, Zhou Y, et al. Association between midlife vascular risk factors and estimated brain amyloid deposition. JAMA. 2017;317(14):1443–50. https://doi.org/10.1001/jama.2017.3090.

Article  CAS 

Comments (0)

No login
gif