Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen associated carbohydrate motifs
Keywords
FIBCD1
crystal structure
binding studies
chitin
innate immunity
ficolins
host-pathogen interaction
structural biology
The abbreviations used areFIBCD1
fibrinogen C domain containing 1
FReD
fibrinogen-like recognition domain
ELISA
enzyme linked immunosorbent assay
ManNAc
N-acetylmannosamine
GlcNAc
N-acetylglucosamine
AcBSA
acetylated bovine serum albumin
MST
MicroScale Thermophoresis
(GlcNAc)n
β-1,4-linked oligosaccharide of GlcNAc with a polymerization degree of n
CSA/C
chondroitin sulfate A/C mixed oligomer
CHO
Chinese hamster ovary cells
© 2023 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.
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