Non-invasive differentiation of hepatic steatosis and steatohepatitis in a mouse model using nitroxyl radical as an MRI-contrast agent
AbbreviationsROS
reactive oxygen species
ESR
electron spin resonance
DNP-MRI
dynamic nuclear polarization-magnetic resonance imaging
MCD
methionine choline deficient
MRI
magnetic resonance imaging
PBS
phosphate buffered saline
CNR
contrast-to-noise ratio
NASH
non-alcoholic steatohepatitis
RARE
rapid acquisition with relaxation enhancement
AUC
area under the hepatic signal intensity change rate-time curve
NAFLD
non-alcoholic fatty liver disease
SAF-A score
the activity part of the Steatosis, Activity, and Fibrosis score
USPIOs,
ultrasmall superparamagnetic iron oxide particles
Keywords
Steatohepatitis
magnetic resonance imaging
nitroxyl radicals
reactive oxygen species
Data availability
Data will be made available on request.
© 2023 Published by Elsevier B.V.
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