Skin cancer is the most frequent cancer type in the world population, and the incidence of basal cell carcinoma (BCC, the most frequent skin cancer type) is increasing worldwide and is predicted to increase until 2040 [1]. More than 70% of BCCs occur in head and neck area [2]. The location of the BCC on the face can predict its behavior, as well as tumor size [3]. Lesions located on high-risk areas defined as tumors on the "mask area" of the face (i.e., nose, lips, eyelids, eyebrows, periorbital skin, chin, mandible, ears, preauricular and postauricular areas, temples) have a higher recurrence risk and, small lesions have low recurrence rate [4]. The gold standard treatment for BCC is surgery, but photodynamic therapy (PDT) can be an option, especially when there are multiple lesions as well as comorbidities that contraindicate surgery [5,6]. In order to support a possible indication of the PDT technique for BCC located on the face, it would be important to evaluate of response rates of small BCC treated with PDT.