Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674. https://doi.org/10.1016/j.cell.2011.02.013

Article  CAS  PubMed  Google Scholar 

Cha YJ, Kim E-S, Koo JS (2018) Tumor-associated macrophages and crown-like structures in adipose tissue in breast cancer. Breast Cancer Res Treat 170:15–25. https://doi.org/10.1007/s10549-018-4722-1

Article  CAS  PubMed  Google Scholar 

Quail DF, Dannenberg AJ (2019) The obese adipose tissue microenvironment in cancer development and progression. Nat Rev Endocrinol 15:139–154. https://doi.org/10.1038/s41574-018-0126-x

Article  PubMed  PubMed Central  Google Scholar 

Luen S, Virassamy B, Savas P et al (2016) The genomic landscape of breast cancer and its interaction with host immunity. Breast 29:241–250. https://doi.org/10.1016/j.breast.2016.07.015

Article  PubMed  Google Scholar 

Zhao R, Kaakati R, Liu X et al (2019) CRISPR/Cas9-mediated BRCA1 knockdown adipose stem cells promote breast cancer progression. Plast Reconstr Surg 143:747–756. https://doi.org/10.1097/PRS.0000000000005316

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daniele A, Divella R, Pilato B et al (2021) Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A mini review. Hered Cancer Clin Pract 19:45. https://doi.org/10.1186/s13053-021-00199-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jones LP, Buelto D, Tago E, Owusu-Boaitey KE (2011) Abnormal mammary adipose tissue environment of Brca1 mutant mice show a persistent deposition of highly vascularized multilocular adipocytes. J Cancer Sci Ther. https://doi.org/10.4172/1948-5956.s2-004

Article  PubMed  PubMed Central  Google Scholar 

Ortega FJ, Moreno-Navarrete JM, Mayas D et al (2012) Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects. PLoS ONE 7:e33233. https://doi.org/10.1371/journal.pone.0033233

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehta AK, Cheney EM, Hartl CA et al (2021) Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. Nat Cancer 2:66–82. https://doi.org/10.1038/s43018-020-00148-7

Article  CAS  PubMed  Google Scholar 

Netherlands Code of Conduct for Research Integrity | NWO

NHG-werkgroep: De Bock GH BMCMHRKJDMMVV van der WGWJ NHG-Standaard Borstkanker (M07). . Versie 41, December 2021

Cardoso F, Kyriakides S, Ohno S et al (2019) Early breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up†. Ann Oncol 30:1194–1220. https://doi.org/10.1093/annonc/mdz173

Article  CAS  PubMed  Google Scholar 

Carter JM, Hoskin TL, Pena MA et al (2018) Macrophagic “Crown-like Structures” are associated with an increased risk of breast cancer in benign breast disease. Cancer Prev Res (Phila) 11:113–119. https://doi.org/10.1158/1940-6207.CAPR-17-0245

Article  PubMed  Google Scholar 

Vaysse C, Lømo J, Garred Ø et al (2017) Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer. NPJ Breast Cancer 3:19. https://doi.org/10.1038/s41523-017-0015-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morris PG, Hudis CA, Giri D et al (2011) Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev Res (Phila) 4:1021–1029. https://doi.org/10.1158/1940-6207.CAPR-11-0110

Article  CAS  PubMed  Google Scholar 

Maliniak ML, Cheriyan AM, Sherman ME et al (2020) Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer. Breast Cancer Res 22:65. https://doi.org/10.1186/s13058-020-01308-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iyengar NM, Zhou XK, Gucalp A et al (2016) Systemic correlates of white adipose tissue inflammation in early-stage breast cancer. Clin Cancer Res 22:2283–2289. https://doi.org/10.1158/1078-0432.CCR-15-2239

Article  CAS  PubMed  Google Scholar 

Koru-Sengul T, Santander AM, Miao F et al (2016) Breast cancers from black women exhibit higher numbers of immunosuppressive macrophages with proliferative activity and of crown-like structures associated with lower survival compared to non-black Latinas and Caucasians. Breast Cancer Res Treat 158:113–126. https://doi.org/10.1007/s10549-016-3847-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iyengar NM, Brown KA, Zhou XK et al (2017) Metabolic obesity, adipose inflammation and elevated breast aromatase in women with normal body mass index. Cancer Prev Res (Phila) 10:235–243. https://doi.org/10.1158/1940-6207.CAPR-16-0314

Article  CAS  PubMed  Google Scholar 

Dirat BA, Bochet L, Escourrou G et al (2010) Unraveling the obesity and breast cancer links: a role for cancer-associated adipocytes? Endocr Dev 19:45–52. https://doi.org/10.1159/000316896

Article  PubMed  Google Scholar 

Birts CN, Savva C, Laversin SA et al (2022) Prognostic significance of crown-like structures to trastuzumab response in patients with primary invasive HER2 + breast carcinoma. Sci Rep 12:7802. https://doi.org/10.1038/s41598-022-11696-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn KJ, Park J, Choi Y (2017) Lymphovascular invasion as a negative prognostic factor for triple-negative breast cancer after surgery. Radiat Oncol J 35:332–339. https://doi.org/10.3857/roj.2017.00416

Article  PubMed  PubMed Central  Google Scholar 

Agarwal G, Nanda G, Lal P et al (2016) Outcomes of Triple-Negative Breast Cancers (TNBC) compared with non-TNBC: does the survival vary for all stages? World J Surg 40:1362–1372. https://doi.org/10.1007/s00268-016-3422-4

Article  PubMed  Google Scholar 

Pistelli M, Pagliacci A, Battelli N et al (2013) Prognostic factors in early-stage triple-negative breast cancer: lessons and limits from clinical practice. Anticancer Res 33:2737–2742

CAS  PubMed  Google Scholar 

Nagy JA, Benjamin L, Zeng H et al (2008) Vascular permeability, vascular hyperpermeability and angiogenesis. Angiogenesis 11:109–119. https://doi.org/10.1007/s10456-008-9099-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Claesson-Welsh L (2015) Vascular permeability–the essentials. Ups J Med Sci 120:135–143. https://doi.org/10.3109/03009734.2015.1064501

Article  PubMed  PubMed Central  Google Scholar 

Hellenthal KEM, Brabenec L, Wagner N-M (2022) Regulation and dysregulation of endothelial permeability during systemic inflammation. Cells. https://doi.org/10.3390/cells11121935

Article  PubMed  PubMed Central  Google Scholar 

Tokuhira N, Kitagishi Y, Suzuki M et al (2015) PI3K/AKT/PTEN pathway as a target for Crohn’s disease therapy (Review). Int J Mol Med 35:10–16. https://doi.org/10.3892/ijmm.2014.1981

Article  CAS  PubMed  Google Scholar 

Liu T, Zhang L, Joo D, Sun S-C (2017) NF-κB signaling in inflammation. Signal Transduct Target Ther 2:17023. https://doi.org/10.1038/sigtrans.2017.23

Article  PubMed  PubMed Central  Google Scholar 

Lyons TG (2019) Targeted therapies for triple-negative breast cancer. Curr Treat Opt Oncol 20:82. https://doi.org/10.1007/s11864-019-0682-x

Article  Google Scholar 

Toss A, Venturelli M, Peterle C et al (2017) Molecular biomarkers for prediction of targeted therapy response in metastatic breast cancer: trick or treat? Int J Mol Sci. https://doi.org/10.3390/ijms18010085

Article  PubMed  PubMed Central  Google Scholar 

Steinhaeuser SS, Morera E, Budkova Z et al (2020) ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasion. Lab Invest 100:928–944. https://doi.org/10.1038/s41374-020-0415-6

Article  CAS  PubMed  Google Scholar 

Zhang Y, Li X, Luo Z et al (2020) ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation. Proc Natl Acad Sci U S A 117:3083–3092. https://doi.org/10.1073/pnas.1912774117

Article  CAS  PubMed  PubMed Central  Google Scholar