Predictive role of E2F6 in cancer prognosis and responses of immunotherapy

aGvHD

acute graft-versus-host disease

CAFs

cancer-associated fibroblasts

CCLE

Cancer Cell Line Encyclopedia

ComPPI

Compartmentalized Protein-Protein Interaction Database

DEGs

differentially expressed genes

DSS

disease-specific survival

EMT

epithelial-mesenchymal transition

GSEA

gene set enrichment analysis

GTEx

Genotype-Tissue Expression

ICB

immune checkpoint blockade

ICIs

immune checkpoint inhibitors

MSI

microsatellite instability

NES

normalized enrichment score

PD1

programmed cell death 1

PFI

progression-free interval

PPI

protein–protein interaction

TCGA

The Cancer Genome Atlas

TIMER

Tumor Immune Estimation Resource

TISCH

Tumor Immune Single-cell Hub

TME

tumor microenvironment

TMB

tumor mutational burden

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