Cooper, M. D. & Alder, M. N. The evolution of adaptive immune systems. Cell 124, 815–822 (2006).

Article  CAS  PubMed  Google Scholar 

Irla, M. Instructive cues of thymic T cell selection. Annu. Rev. Immunol. 40, 95–119 (2022).

Article  CAS  PubMed  Google Scholar 

Kadouri, N., Nevo, S., Goldfarb, Y. & Abramson, J. Thymic epithelial cell heterogeneity: TEC by TEC. Nat. Rev. Immunol. 20, 239–253 (2020).

Article  CAS  PubMed  Google Scholar 

Klein, L., Kyewski, B., Allen, P. M. & Hogquist, K. A. Positive and negative selection of the T cell repertoire: what thymocytes see (and don’t see). Nat. Rev. Immunol. 14, 377–391 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taniuchi, I. CD4 helper and CD8 cytotoxic T cell differentiation. Annu. Rev. Immunol. 36, 579–601 (2018).

Article  CAS  PubMed  Google Scholar 

Davenport, M. P., Smith, N. L. & Rudd, B. D. Building a T cell compartment: how immune cell development shapes function. Nat. Rev. Immunol. 20, 499–506 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chapman, N. M. & Chi, H. Metabolic adaptation of lymphocytes in immunity and disease. Immunity 55, 14–30 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campbell, C. & Rudensky, A. Roles of regulatory T cells in tissue pathophysiology and metabolism. Cell Metab. 31, 18–25 (2020).

Article  CAS  PubMed  Google Scholar 

Bennett, C. L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20–21 (2001).

Article  CAS  PubMed  Google Scholar 

Pohar, J., Simon, Q. & Fillatreau, S. Antigen−specificity in the thymic development and peripheral activity of CD4+FOXP3+ T regulatory cells. Front Immunol. 9, 1701 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Savage, P. A., Klawon, D. E. J. & Miller, C. H. Regulatory T cell development. Annu. Rev. Immunol. 38, 421–453 (2020).

Article  CAS  PubMed  Google Scholar 

van der Veeken, J. et al. Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity 55, 1173–1184 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Kitagawa, Y. et al. Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment. Nat. Immunol. 18, 173–183 (2017).

Article  CAS  PubMed  Google Scholar 

Arpaia, N. et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504, 451–455 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gutcher, I. et al. Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity 34, 396–408 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith, P. M. et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341, 569–573 (2013).

Article  CAS  PubMed  Google Scholar 

Newton, R., Priyadharshini, B. & Turka, L. A. Immunometabolism of regulatory T cells. Nat. Immunol. 17, 618–625 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berod, L. et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20, 1327–1333 (2014).

Article  CAS  PubMed  Google Scholar 

Field, C. S. et al. Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function. Cell Metab. 31, 422–437 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

AM, A. L., Syed, D. N. & Ntambi, J. M. Insights into stearoyl-CoA desaturase-1 regulation of systemic metabolism. Trends Endocrinol. Metab. 28, 831–842 (2017).

Article  Google Scholar 

Liu, K. et al. Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II. Proc. Natl Acad. Sci. USA 117, 2462–2472 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lochner, M., Berod, L. & Sparwasser, T. Fatty acid metabolism in the regulation of T cell function. Trends Immunol. 36, 81–91 (2015).

Article  CAS  PubMed  Google Scholar 

Mottet, C., Uhlig, H. H. & Powrie, F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J. Immunol. 170, 3939–3943 (2003).

Article  CAS  PubMed  Google Scholar 

Owen, D. L. et al. Thymic regulatory T cells arise via two distinct developmental programs. Nat. Immunol. 20, 195–205 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235–238 (2006).

Article  CAS  PubMed  Google Scholar 

Schmitt, T. M. & Zuniga-Pflucker, J. C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17, 749–756 (2002).

Article  CAS  PubMed  Google Scholar 

den Braber, I. et al. Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity 36, 288–297 (2012).

Article  Google Scholar 

Sukseree, S. et al. Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model. PLoS ONE 7, e38933 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sampath, H. et al. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J. Biol. Chem. 284, 19961–19973 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xue, Y. et al. SCD1 sustains homeostasis of bulge niche via maintaining hemidesmosomes in basal keratinocytes. Adv. Sci. 10, e2201949 (2023).

Article  Google Scholar 

Vassar, R., Rosenberg, M., Ross, S., Tyner, A. & Fuchs, E. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc. Natl Acad. Sci. USA 86, 1563–1567 (1989).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trebak, M. & Kinet, J. P. Calcium signalling in T cells. Nat. Rev. Immunol. 19, 154–169 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon, R. E. et al. Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels. Elife 4, e05608 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Vaeth, M. et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc. Natl Acad. Sci. USA 109, 16258–16263 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, M. O. & Rudensky, A. Y. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat. Rev. Immunol. 16, 220–233 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia, B. A. et al. Chemical derivatization of histones for facilitated analysis by mass spectrometry. Nat. Protoc. 2, 933–938 (2007).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrari, F. et al. DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility. Nat. Commun. 11, 5200 (2020).

Article  CAS