McCaddon A., Hudson P.R. 2010. L-Methylfolate, methylcobalamin, and N -acetylcysteine in the treatment of Alzheimer’s disease-related cognitive decline. CNS Spectr. 15, 2–5.

Article  PubMed  Google Scholar 

Regland B., Forsmark S., Halaouate L., Matousek M., Peilot B., Zachrisson O., Gottfries C.-G. 2015. Re-sponse to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 10, e0124648.

Article  PubMed  PubMed Central  Google Scholar 

Wheatley C. 2006. A scarlet pimpernel for the resolution of inflammation? The role of supra-therapeutic doses of cobalamin, in the treatment of systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic or traumatic shock. Med. Hypotheses. 67, 124–142.

Article  CAS  PubMed  Google Scholar 

Patel J.J., Willoughby R., Peterson J., Carver T., Zelten J., Markiewicz A., Spiegelhoff K., Hipp L.A., Canales B., Szabo A., Heyland D.K., Stoppe C., Zielonka J., Freed J.K. 2023. High-dose IV hydroxocobalamin (vitamin B12) in septic shock. Chest. 163, 303–312.

Article  CAS  PubMed  Google Scholar 

Kalra S., Ahuja R., Mutti E., Veber D., Seetharam S., Scalabrino G., Seetharam B. 2007. Cobalamin-mediated regulation of transcobalamin receptor levels in rat organs. Arch. Biochem. Biophys. 463, 128–132.

Article  CAS  PubMed  Google Scholar 

Rothenberg S.P., Quadros E.V., Regec A. 1999. Transcobalamin II. In Chemistry and Biochemistry of Vitamin B12. Banerjee R., Ed. New York: Wiley,  441–473.

Google Scholar 

Pastore A., Martinelli D., Piemonte F., Tozzi G., Boenzi S., Di Giovamberardino G., Petrillo S., Bertini E., Dionisi-Vici C. 2014. Glutathione metabolism in cobalamin deficiency type C (cblC). J. Inherit. Metab. Dis. 37, 125–129.

Article  CAS  PubMed  Google Scholar 

Shatalin Y.V., Shubina V.S., Solovieva M.E., Akatov V.S. 2022. Differences in the formation of reactive oxygen species and their cytotoxicity between thiols combined with aqua- and cyanocobalamins. Int. J. Mol. Sci. 23, 11032.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brayfield A. 2014. Martindale: The Complete Drug Reference. London, UK: Pharm Press.

Google Scholar 

Xia L., Cregan A.G., Berben L.A., Brasch N.E. 2004. Studies on the formation of glutathionylcobalamin: Any free intracellular aquacobalamin is likely to be rapidly and irreversibly converted to glutathionylcobalamin. Inorg. Chem. 43, 6848–6857.

Article  CAS  PubMed  Google Scholar 

Wingert V., Mukherjee S., Esser A.J., Behringer S., Tanimowo S., Klenzendorf M., Derevenkov I.A., Makarov S.V., Jacobsen D.W., Spiekerkoetter U., Hannibal L. 2021. Thiolatocobalamins repair the activity of pathogenic variants of the human cobalamin processing enzyme CblC. Biochimie. 183, 108–125.

Article  CAS  PubMed  Google Scholar 

Salnikov D.S., Kucherenko P.N., Dereven’kov I.A., Makarov S.V., van Eldik R. 2014. Kinetics and mechanism of the reaction of hydrogen sulfide with cobalamin in aqueous solution. Eur. J. Inorg. Chem. 2014, 852–862.

Article  CAS  Google Scholar 

Suarez-Moreira E., Hannibal L., Smith C.A., Chavez R.A., Jacobsen D.W., Brasch N.E. 2006. A simple, convenient method to synthesize cobalamins: Synthesis of homocysteinylcobalamin, N-acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, sulfitocobalamin and nitrocobalamin. Dalton Trans. Camb. Engl. 2003. 5269–5277.

Article  Google Scholar 

Paul C., Brady D.M. 2017. Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms. Integr. Med. Encinitas Calif. 16, 42–49.

Google Scholar 

Zhang Y., Hodgson N., Trivedi M., Deth R. 2016. Neuregulin 1 promotes glutathione-dependent neuronal cobalamin metabolism by stimulating cysteine uptake. Oxid. Med. Cell. Longev. 2016, 1–13.

Google Scholar 

Pezacka E., Green R., Jacobsen D.W. 1990. Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes. Biochem. Biophys. Res. Commun. 169, 443–450.

Article  CAS  PubMed  Google Scholar 

George P., Irvine D.H., Glauser S.C. 2006. The influence of chelation in determining the reactivity of the iron in hemoproteins. and the cobalt in vitamin B12 derivatives. Ann. N.Y. Acad. Sci. 88, 393–415.

Article  Google Scholar 

Green R., Allen L.H., Bjørke-Monsen A.L., Brito A., Guéant J.L., Miller J.W., Molloy A.M., Nexo E., Stabler S., Toh B.H., Ueland P.M., Yajnik C. 2017. Correction: Vitamin B12 deficiency. Nat. Rev. Dis. Primer. 3, 17040.

Article  Google Scholar 

Esser A.J., Mukherjee S., Dereven’kov I.A., Makarov S.V., Jacobsen D.W., Spiekerkoetter U., Hannibal L. 2022. Versatile enzymology and heterogeneous phenotypes in cobalamin complementation type C disease. iScience. 25, 104981.

Rizzo G., Laganà A.S. 2020. A review of vitamin B12. In Molecular Nutrition. Elsevier, pp. 105–129.

Google Scholar 

Obeid R., Fedosov S.N., Nexo E. 2015. Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol. Nutr. Food Res. 59, 1364–1372.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Froese D.S., Gravel R.A. 2010. Genetic disorders of vitamin B12 metabolism: Eight complementation groups–eight genes. Expert. Rev. Mol. Med. 12, e37.

Article  PubMed  PubMed Central  Google Scholar 

Bassila C., Ghemrawi R., Flayac J., Froese D.S., Baumgartner M.R., Guéant J.-L., Coelho D. 2017. Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC. Biochim. Biophys. Acta, Mol. Basis Dis. 1863, 103–112.

Article  CAS  Google Scholar 

Ankar A., Kumar A. 2023. Vitamin B12 deficiency. In StatPearls. Treasure Island (FL): StatPearls.

Google Scholar 

Joint Formulary Committee (Great Britain) 2020. BNF 80: September 2020–March 2021. London: BMJ Group, Pharmaceutical Press.

Vidal-Alaball J., Butler C., Cannings-John R., Goringe A., Hood K., McCaddon A., McDowell I., Papaioannou A. 2005. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst. Rev. 3, Ed. Cochrane Metabolic and Endocrine Disorders Group. CD004655.

Clinical Recommendations “Vitamin-B12-Deficiency Anemia” 2021, developed by the National Hematological Society, the National Society of Pediatric Hematologists and Oncologists. Approved by the Ministry of Health of the Russian Federation. https://cr.minzdrav.gov.ru/schema/536_2.

Anon. 2008 Physicians’ Desk Reference: PDR 2008. 62nd. ed. Montvale, N.J.: Thomson Healthcare, p. 3480.

Google Scholar 

Forsyth J.C., Mueller P.D., Becker C.E., Osterloh J., Benowitz N.L., Rumack B.H., Hall A.H. 1993. Hydroxocobalamin as a cyanide antidote: Safety, efficacy and pharmacokinetics in heavily smoking normal volunteers. J. Toxicol. Clin. Toxicol. 31, 277–294.

Article  CAS  PubMed  Google Scholar 

Bak M.A., Smith J.A., Murfin B., Chen Y. 2022. High-dose hydroxocobalamin for refractory vasoplegia post cardiac surgery. Cureus. 14 (8), e28267.23.

Andersson H.C., Shapira E. 1998. Biochemical and clinical response to hydroxocobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC). J. Pediatr. 132, 121–124.

Article  CAS  PubMed  Google Scholar 

Bodamer O.A.F., Rosenblatt D.S., Appel S.H., Beaudet A.L. 2001. Adult-onset combined methylmalonic aciduria and homocystinuria (cblC). Neurology. 56, 1113–1113.

Article  CAS  PubMed  Google Scholar 

Huemer M., Diodato D., Schwahn B., Schiff M., Bandeira A., Benoist J.F., Burlina A., Cerone R., Couce M.L., Garcia-Cazorla A., la Marca G., Pasquini E., Vilarinho L., Weisfeld-Adams J.D., Kožich V., Blom H., Baumgartner M.R., Dionisi-Vici C. 2017. Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency. J. Inherit. Metab. Dis. 40, 21–48.

Article  CAS  PubMed  Google Scholar 

Almannai M., Marom R., Divin K., Scaglia F., Sutton V.R., Craigen W.J., Lee B., Burrage L.C., Graham B.H. 2017. Milder clinical and biochemical phenotypes associated with the c.482G>A (p.Arg161Gln) pathogenic variant in cobalamin C disease: Implications for management and screening. Mol. Genet. Metab. 122, 60–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Higashimoto T., Kim A.Y., Ogawa J.T., Sloan J.L., Almuqbil M.A., Carlson J.M., Manoli I., Venditti C.P., Gunay-Aygun M., Wang T. 2020. High dose hydroxocobalamin achieves biochemical correction and improvement of neuropsychiatric deficits in adults with late onset cobalamin C deficiency. JIMD Rep. 51, 17–24.

Article  PubMed  Google Scholar 

Fischer S., Huemer M., Baumgartner M., Deodato F., Ballhausen D., Boneh A., Burlina A.B., Cerone R., Garcia P., Gökçay G., Grünewald S., Häberle J., Jaeken J., Ketteridge D., Lindner M., Mandel H., Martinelli D., Martins E.G., Schwab K.O., Gruenert S.C., Schwahn B.C., Sztriha L., Tomaske M., Trefz F., Vilarinho L., Rosenblatt D.S., Fowler B., Dionisi-Vici C. 2014. Clinical presentation and outcome in a series of 88 patients with the cblC defect. J. Inherit. Metab. Dis. 37, 831–840.

Article  CAS  PubMed  Google Scholar 

Carrillo-Carrasco N., Sloan J., Valle D., Hamosh A., Venditti C.P. 2009. Hydroxocobalamin dose escalation improves metabolic control in cblC. J. Inherit. Metab. Dis. 32, 728–731.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Hove J.L., Van Damme-Lombaerts R., Grünewald S., Peters H., Van Damme B., Fryns J.P., Arnout J., Wevers R., Baumgartner E.R., Fowler B. 2002. Cobalamin disorder cblC presenting with late-onset thrombotic microangiopathy. Am. J. Med. Genet. 111, 195–201.

Article  PubMed  Google Scholar 

Matos I.V., Castejón E., Meavilla S., O’Callaghan M., Garcia-Villoria J., López-Sala A., Ribes A., Artuch R., Garcia-Cazorla A. 2013. Clinical and biochemical out-come after hydroxocobalamin dose escalation in a series of patients with cobalamin C deficiency. Mol. Genet. Metab. 109, 360–365.

Article  CAS  PubMed  Google Scholar 

Scalabrino G., Carpo M., Bamonti F., Pizzinelli S., D’Avino C., Bresolin N., Meucci G., Martinelli V., Comi G.C., Peracchi M. 2004. High tumor necrosis factor-alfa in levels in cerebrospinal fluid of cobalamin-deficient patients. Ann. Neurol. 56, 886–890.

Article  PubMed  Google Scholar 

Tamura J., Kubota K., Murakami H., Sawamura M., Matsushima T., Tamura T., Saitoh T., Kurabayshi H., Naruse T. 1999. Immunomodulation by vitamin B12: Augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment: Vit.B12 augments CD8+ cells and NK cell activity. Clin. Exp. Immunol. 116, 28–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Veber D., Mutti E., Tacchini L., Gammella E., Tredici G., Scalabrino G. 2008. Indirect down-regulation of nuclear NF-κB levels by cobalamin in the spinal cord and liver of the rat. J. Neurosci. Res