Osteopontin: A Novel Therapeutic Target for Respiratory Diseases

Sécher T, Guilleminault L, Reckamp K et al (2018) Therapeutic antibodies: a new era in the treatment of respiratory diseases? Pharmacol Ther 189:149–172

Article  PubMed  Google Scholar 

Ashkar S, Weber GF, Panoutsakopoulou V et al (2000) Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science 287(5454):860–864

Article  CAS  PubMed  Google Scholar 

Chen G, Zhang X, Li R et al (2010) Role of osteopontin in synovial Th17 differentiation in rheumatoid arthritis. Arthritis Rheum 62(10):2900–2908

Article  CAS  PubMed  Google Scholar 

Sawaki D, Czibik G, Pini M et al (2018) Visceral adipose tissue drives cardiac aging through modulation of fibroblast senescence by osteopontin production. Circulation 138(8):809–822

Article  CAS  PubMed  Google Scholar 

Szalay G, Sauter M, Haberland M et al (2009) Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. Cir Res 104(7):851–859

Article  CAS  Google Scholar 

Khamissi FZ, Ning L, Kefaloyianni E et al (2022) Identification of kidney injury released circulating osteopontin as causal agent of respiratory failure. Sci Adv 8(8):eabm5900

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morse C, Tabib T, Sembrat J et al (2019) Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis. Eur Respir J 54(2):1802441

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu Y, Zhang Y, Lei Z et al (2020) Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer. J Hematol Oncol 13(1):169

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morimoto Y, Hirahara K, Kiuchi M et al (2018) Amphiregulin-producing pathogenic memory T helper 2 cells instruct Eosinophils to secrete osteopontin and facilitate airway fibrosis. Immunity 49(1):134-150.e136

Article  CAS  PubMed  Google Scholar 

Saker M, Lipskaia L, Marcos E et al (2016) Osteopontin, a key mediator expressed by senescent pulmonary vascular cells in pulmonary hypertension. Arterioscler Thromb Vasc Biol 36(9):1879–1890

Article  CAS  PubMed  Google Scholar 

Singh A, Gill G, Kaur H et al (2018) Role of osteopontin in bone remodeling and orthodontic tooth movement: a review. Prog Orthod 19(1):18

Article  PubMed  PubMed Central  Google Scholar 

Liaw L, Birk DE, Ballas CB et al (1998) Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest 101(7):1468–1478

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi L, Sun Z, Su W et al (2021) Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke. Immunity 54(7):1527-1542.e1528

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fong YC, Liu SC, Huang CY et al (2009) Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway. Lung Cancer 64(3):263–270

Article  PubMed  Google Scholar 

Dai J, Peng L, Fan K et al (2009) Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells. Oncogene 28(38):3412–3422

Article  CAS  PubMed  Google Scholar 

Leavenworth JW, Verbinnen B, Wang Q et al (2015) Intracellular osteopontin regulates homeostasis and function of natural killer cells. Proc Natl Acad Sci USA 112(2):494–499

Article  CAS  PubMed  Google Scholar 

Shinohara ML, Kim JH, Garcia VA et al (2008) Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 29(1):68–78

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao K, Zhang M, Zhang L et al (2016) Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response. Sci Rep 6:23771

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rizzello C, Cancila V, Sangaletti S et al (2022) Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling. Mol Cancer 21(1):215

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christensen B, Petersen TE, Sørensen ES (2008) Post-translational modification and proteolytic processing of urinary osteopontin. Biochem J 411(1):53–61

Article  CAS  PubMed  Google Scholar 

Kaartinen MT, Pirhonen A, Linnala-Kankkunen A et al (1999) Cross-linking of osteopontin by tissue transglutaminase increases its collagen binding properties. J Biol Chem 274(3):1729–1735

Article  CAS  PubMed  Google Scholar 

Yokosaki Y, Tanaka K, Higashikawa F et al (2005) Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin. Matrix Biol 24(6):418–427

Article  CAS  PubMed  Google Scholar 

Bayless KJ, Davis GE (2001) Identification of dual alpha 4beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin. J Biol Chem 276(16):13483–13489

Article  CAS  PubMed  Google Scholar 

Weber GF, Ashkar S, Glimcher MJ et al (1996) Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science 271(5248):509–512

Article  CAS  PubMed  Google Scholar 

Sun BS, Li Y, Zhang ZF et al (2013) Osteopontin combined with CD44v6, a novel prognostic biomarker in non-small cell lung cancer undergoing curative resection. Ann Thorac Surg 96(6):1943–1951

Article  PubMed  Google Scholar 

Kim JS, Bashir MM, Werth VP (2012) Gottron’s papules exhibit dermal accumulation of CD44 variant 7 (CD44v7) and its binding partner osteopontin: a unique molecular signature. J Invest Dermatol 132(7):1825–1832

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raineri D, Dianzani C, Cappellano G et al (2020) Osteopontin binds ICOSL promoting tumor metastasis. Commun Biol 3(1):615

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mukherjee BB, Nemir M, Beninati S et al (1995) Interaction of osteopontin with fibronectin and other extracellular matrix molecules. Ann N Y Acad Sci 760:201–212

Article  CAS  PubMed  Google Scholar 

Christensen B, Nielsen MS, Haselmann KF et al (2005) Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. Biochem J 390(Pt 1):285–292

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schytte GN, Christensen B, Bregenov I et al (2020) FAM20C phosphorylation of the RGDSVVYGLR motif in osteopontin inhibits interaction with the αvβ3 integrin. J Cell Biochem. https://doi.org/10.1002/jcb.29708

Article  PubMed  Google Scholar 

Jono S, Peinado C, Giachelli CM (2000) Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification. J Biol Chem 275(26):20197–20203

Article  CAS  PubMed  Google Scholar 

Minai-Tehrani A, Chang SH, Park SB et al (2013) The O-glycosylation mutant osteopontin alters lung cancer cell growth and migration in vitro and in vivo. Int J Mol Med 32(5):1137–1149

Article  CAS  PubMed  Google Scholar 

Christensen B, Zachariae ED, Scavenius C et al (2016) Transglutaminase 2-catalyzed intramolecular cross-linking of osteopontin. Biochemistry 55(2):294–303

Article  CAS  PubMed  Google Scholar 

Higashikawa F, Eboshida A, Yokosaki Y (2007) Enhanced biological activity of polymeric osteopontin. FEBS Lett 581(14):2697–2701

Article  CAS  PubMed  Google Scholar 

Forsprecher J, Wang Z, Goldberg HA et al (2011) Transglutaminase-mediated oligomerization promotes osteoblast adhesive properties of osteopontin and bone sialoprotein. Cell Adh Migr 5(1):65–72

Article  PubMed  PubMed Central  Google Scholar 

Bos LDJ, Ware LB (2022) Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet 400(20358):1145–1156

Article  PubMed 

留言 (0)

沒有登入
gif