aDepartment of Gastroenterology and Hepatology, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom;

bDepartment of Clinical and Experimental Medicine, Brighton and Sussex Medical School, Brighton, United Kingdom;

cDepartment of Hepatology, Royal Free Hospital, London, United Kingdom;

dDepartment of HIV and Sexual Health, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom; and

eBrighton and Sussex Medical School, Brighton, United Kingdom.

Correspondence to: Sumita Verma, MBBS, MD, FRCP, Brighton and Sussex Medical School, Main Teaching Building, Room 2.17, North South Road, Falmer, Brighton BN1 9PX, United Kingdom (e-mail: [email protected]).

S.V. none pertaining to this manuscript. In general, research grants, consultancy and speaker fees Gilead Sciences; Speaker Fees Abbvie; supply of consumables Rocket Medical/Becton Dickinson; Y.G. none pertaining to this manuscript. In general research grants, consultancy and speaker fees Gilead Sciences, ViiV and Dr Falk. The remaining authors have no funding or conflicts of interest to disclose.

D.K. recruitment, data entry and analysis; J.R.P. statistical analysis oversight and critical revisions; Y.T., L.V., A.B., H.S., B.P. recruitment and data entry; Y.G. study design and critical revisions; S.V. study design, wrote first draft with input from D.K. and A.M. and critical revisions. All authors have viewed and approved the final manuscript draft. S.V. is the submission's guarantor.

Y.T. and A.M. contributed as joint second author.

Y.G. and S.V. contributed as joint senior authors.

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