Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P, Milat F (2022) Secondary osteoporosis. Endocr Rev 43:240–313

Article  PubMed  Google Scholar 

Zheng J, Brion MJ, Kemp JP, Warrington NM, Borges MC, Hemani G, Richardson TG, Rasheed H, Qiao Z, Haycock P, Ala-Korpela M, Davey Smith G, Tobias JH, Evans DM (2020) The effect of plasma lipids and lipid-lowering interventions on bone mineral density: a Mendelian randomization study. J Bone Miner Res 35:1224–1235

Article  CAS  PubMed  Google Scholar 

Yin W, Li Z, Zhang W (2019) Modulation of bone and marrow niche by cholesterol. Nutrients 11:1394

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science (New York) 284:143–147

Article  CAS  Google Scholar 

Viswanathan S, Shi Y, Galipeau J, Krampera M, Leblanc K, Martin I, Nolta J, Phinney DG, Sensebe L (2019) Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature. Cytotherapy 21:1019–1024

Article  CAS  PubMed  Google Scholar 

Fu X, Liu G, Halim A, Ju Y, Luo Q, Song AG (2019) Mesenchymal stem cell migration and tissue repair. Cells 8:784

Article  CAS  PubMed  PubMed Central  Google Scholar 

King S, Klineberg I, Brennan-Speranza TC (2022) Adipose tissue dysfunction: impact on bone and osseointegration. Calcif Tissue Int 110:32–40

Article  CAS  PubMed  Google Scholar 

Qadir A, Liang S, Wu Z, Chen Z, Hu L, Qian A (2020) Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells. Int J Mol Sci 21:349

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parhami F, Garfinkel A, Demer LL (2000) Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol 20:2346–2348

Article  CAS  PubMed  Google Scholar 

Casado-Díaz A, Túnez-Fiñana I, Mata-Granados JM, Ruiz-Méndez MV, Dorado G, Romero-Sánchez MC, Navarro-Valverde C, Quesada-Gómez JM (2017) Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC). Exp Gerontol 90:71–78

Article  PubMed  Google Scholar 

Tiwari A, Mukherjee B, Dixit M (2018) MicroRNA key to angiogenesis regulation: MiRNA biology and therapy. Curr Cancer Drug Targets 18:266–277

Article  CAS  PubMed  Google Scholar 

Fierro-Fernández M, Miguel V, Márquez-Expósito L, Nuevo-Tapioles C, Herrero JI, Blanco-Ruiz E, Tituaña J, Castillo C, Cannata P, Monsalve M, Ruiz-Ortega M, Ramos R, Lamas S (2020) MiR-9-5p protects from kidney fibrosis by metabolic reprogramming. FASEB J 34:410–431

Article  PubMed  Google Scholar 

Mota de Sá P, Richard AJ, Hang H, Stephens JM (2017) Transcriptional regulation of adipogenesis. Compr Physiol 7:635–674

Article  PubMed  Google Scholar 

Han L, Wang B, Wang R, Gong S, Chen G, Xu W (2019) The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor. Stem Cell Res Ther 10:377

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang YC, Li Y, Wang XY, Zhang D, Zhang H, Wu Q, He YQ, Wang JY, Zhang L, Xia H, Yan J, Li X, Ying H (2013) Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity. Diabetologia 56:2275–2285

Article  CAS  PubMed  Google Scholar 

Luo W, Kim Y, Jensen ME, Herlea-Pana O, Wang W, Rudolph MC, Friedman JE, Chernausek SD, Jiang S (2022) miR-130b/301b is a negative regulator of beige adipogenesis and energy metabolism in vitro and in vivo. Diabetes 71:2360–2371

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang S, Teague AM, Tryggestad JB, Chernausek SD (2017) Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway. Biochem Biophys Res Commun 487:607–612

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115–124

Article  CAS  PubMed  Google Scholar 

Liang H, Ward WF (2006) PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ 30:145–151

Article  PubMed  Google Scholar 

Li L, Wang B, Li Y, Li L, Dai Y, Lv G, Wu P, Li P (2020) Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling. Aging 12:16887–16898

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen Y, Wu L, Qin D, Xia Y, Zhou Z, Zhang X, Wu X (2018) Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria. Part Fibre Toxicol 15:16

Article  PubMed  PubMed Central  Google Scholar 

Miles MV (2007) The uptake and distribution of coenzyme Q10. Mitochondrion 7(Suppl):S72-77

Article  CAS  PubMed  Google Scholar 

Pallotti F, Bergamini C, Lamperti C, Fato R (2021) The roles of coenzyme q in disease: direct and indirect involvement in cellular functions. Int J Mol Sci 23:128

Article  PubMed  PubMed Central  Google Scholar 

Testai L, Martelli A, Flori L, Cicero AFG, Colletti A (2021) Coenzyme Q(10): clinical applications beyond cardiovascular diseases. Nutrients 13:1697

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsai KL, Chen LH, Chiou SH, Chiou GY, Chen YC, Chou HY, Chen LK, Chen HY, Chiu TH, Tsai CS, Ou HC, Kao CL (2011) Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway. Mol Nutr Food Res 55(Suppl 2):S227-240

CAS  PubMed  Google Scholar 

Wear D, Vegh C, Sandhu JK, Sikorska M, Cohen J, Pandey S (2021) Ubisol-Q(10), a nanomicellar and water-dispersible formulation of coenzyme-Q(10) as a potential treatment for Alzheimer’s and Parkinson’s disease. Antioxidants (Basel, Switzerland) 10:764

CAS  PubMed  Google Scholar 

Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H, Pandey S (2005) Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis 18:618–627

Article  CAS  PubMed  Google Scholar 

Allen RM, Vickers KC (2014) Coenzyme Q10 increases cholesterol efflux and inhibits atherosclerosis through microRNAs. Arterioscler Thromb Vasc Biol 34:1795–1797

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Wang C, Jin Y, Yang Q, Meng Q, Liu Q, Dai Y, Cai L, Liu Z, Liu K, Sun H (2018) Activating the PGC-1α/TERT pathway by catalpol ameliorates atherosclerosis via modulating ROS production, DNA damage, and telomere function: implications on mitochondria and telomere link. Oxid Med Cell Longev 2018:2876350

Article  PubMed  PubMed Central  Google Scholar 

Li X, Zhan J, Hou Y, Hou Y, Chen S, Luo D, Luan J, Wang L, Lin D (2019) Coenzyme Q10 regulation of apoptosis and oxidative stress in H(2)O(2) induced BMSC death by modulating the Nrf-2/NQO-1 signaling pathway and its application in a model of spinal cord injury. Oxid Med Cell Longev 2019:6493081

Article  PubMed  PubMed Central  Google Scholar 

Montero M, Díaz-Curiel M, Guede D, Caeiro JR, Martín-Fernández M, Rubert M, Navarro D, de la Piedra C (2012) Effects of kalsis, a dietary supplement, on bone metabolism in the ovariectomized rats. J Osteoporos 2012:639427

Article  PubMed  PubMed Central  Google Scholar 

Nie F, Zhang W, Cui Q, Fu Y, Li H, Zhang J (2020) Kaempferol promotes proliferation and osteogenic differentiation of periodontal ligament stem cells via Wnt/β-catenin signaling pathway. Life Sci 258:118143

Article  CAS  PubMed  Google Scholar 

Mai FY, He P, Ye JZ, Xu LH, Ouyang DY, Li CG, Zeng QZ, Zeng CY, Zhang CC, He XH, Hu B (2019) Caspase-3-mediated GSDME activation contributes to cisplatin- and doxorubicin-induced secondary necrosis in mouse macrophages. Cell Prolif 52:e12663

Article  PubMed  PubMed Central  Google Scholar 

Rizo-Liendo A, Sifaoui I, Arberas-Jiménez I, Reyes-Batlle M, Piñero JE, Lorenzo-Morales J (2020) Fluvastatin and atorvastatin induce programmed cell death in the brain eating amoeba Naegleria fowleri. Biomed Pharmacother 130:110583

Article  CAS  PubMed  Google Scholar 

Park KR, Lee JY, Kim BM, Kang SW, Yun HM (2020) TMARg, a novel anthraquinone isolated from Rubia cordifolia Nakai, increases osteogenesis and mineralization through BMP2 and β-catenin signaling. Int J Mol Sci 21:5332

Article  CAS