Reply to the Letter to the Editor “Frailty Is a Risk Factor for Falls in the Older Adults: A Systematic Review and Meta-Analysis”

We extracted data in the form of 2×2 contingency tables from all the articles for our analysis. Given that all the studies were cohort in design, we opted for the Relative Risk (RR) as the unified effect size. However, to ensure robustness and transparency in our approach, we also analyzed studies based on their reported effect sizes separately: For the 20 studies that reported Odds Ratios (OR), the pooled OR indicated that frail elderly individuals had a 1.89 times higher likelihood of falling compared to their non-frail counterparts (OR 1.89, 95% CI: 1.54–2.33, I2 87.8%). For the 7 studies that reported RRs, the combined RR was 1.68 (95% CI: 1.32–2.14, I2 98%). For the 2 studies that reported Hazard Ratios (HR), the pooled HR was 1.55 (95% CI: 1.52–1.58, I2 47.8%). Due to the multiplicity of effect sizes and to maintain clarity in our presentation, we showcased a unified effect size in our main results..

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