1Department of Gastroenterology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China;

2Department of Gastroenterology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China;

3Department of Pharmacology, College of Pharmacy, Naval Medical University, Shanghai, 200433, China.

Correspondence: Yu Liu, MD. E-mail: [email protected].

*Jin-Hui Yi and Jin-Jie Xu contributed equally to this work.