van der Meijden, P. E. J. & Heemskerk, J. W. M. Platelet biology and functions: new concepts and clinical perspectives. Nat. Rev. Cardiol. 16, 166–179 (2019).
Gaertner, F. & Massberg, S. Patrolling the vascular borders: platelets in immunity to infection and cancer. Nat. Rev. Immunol. 19, 747–760 (2019).
Article CAS PubMed Google Scholar
Levin, J. & Conley, C. L. Thrombocytosis associated with malignant disease. Arch. Intern. Med. 114, 497–500 (1964).
Article CAS PubMed Google Scholar
Lin, R. J., Afshar-Kharghan, V. & Schafer, A. I. Paraneoplastic thrombocytosis: the secrets of tumor self-promotion. Blood 124, 184–187 (2014).
Article CAS PubMed PubMed Central Google Scholar
Cho, M. S. et al. Platelets increase the proliferation of ovarian cancer cells. Blood 120, 4869–4872 (2012).
Article CAS PubMed PubMed Central Google Scholar
Labelle, M., Begum, S. & Hynes, R. O. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20, 576–590 (2011). This paper shows that platelets promote epithelial-to-mesenchymal-like transition of cancer cells through both contact-dependent and contact-independent mechanisms.
Article CAS PubMed PubMed Central Google Scholar
Placke, T. et al. Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells. Cancer Res. 72, 440–448 (2012).
Article CAS PubMed Google Scholar
Rachidi, S. et al. Platelets subvert T cell immunity against cancer via GARP-TGFβ axis. Sci. Immunol. 2, eaai7911 (2017).
Article PubMed PubMed Central Google Scholar
Casagrande, N. et al. In ovarian cancer multicellular spheroids, platelet releasate promotes growth, expansion of ALDH+ and CD133+ cancer stem cells, and protection against the cytotoxic effects of cisplatin, carboplatin and paclitaxel. Int. J. Mol. Sci. 22, 3019 (2021).
Article CAS PubMed PubMed Central Google Scholar
Palumbo, J. S. et al. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 105, 178–185 (2005).
Article CAS PubMed Google Scholar
Gay, L. J. & Felding-Habermann, B. Contribution of platelets to tumour metastasis. Nat. Rev. Cancer 11, 123–134 (2011).
Article CAS PubMed PubMed Central Google Scholar
Dangaj, D. et al. Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors. Cancer Cell 35, 885–900.e10 (2019).
Article CAS PubMed PubMed Central Google Scholar
Stone, R. L. et al. Paraneoplastic thrombocytosis in ovarian cancer. N. Engl. J. Med. 366, 610–618 (2012). This paper shows that ovarian tumour cells secrete IL-6, which increases hepatic thrombopoietin production and promotes platelet generation.
Article CAS PubMed PubMed Central Google Scholar
Xu, X. R., Yousef, G. M. & Ni, H. Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents. Blood 131, 1777–1789 (2018).
Article CAS PubMed Google Scholar
Bailey, S. E., Ukoumunne, O. C., Shephard, E. A. & Hamilton, W. Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data. Br. J. Gen. Pract. 67, e405–e413 (2017).
Article PubMed PubMed Central Google Scholar
Abdulrahman, G. O., Das, N. & Lutchman Singh, K. The predictive role of thrombocytosis in benign, borderline and malignant ovarian tumors. Platelets 31, 795–800 (2020).
Article CAS PubMed Google Scholar
Hwang, S. G. et al. Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer. Eur. J. Surg. Oncol. 38, 562–567 (2012).
Article CAS PubMed Google Scholar
Skorek, P., Stepien, K., Fila, M., Hauer, J. & Kuzdzal, J. Preoperative thrombocytosis in surgically treated patients with non-small cell lung cancer. Pol. Arch. Intern. Med. 128, 512–517 (2018).
Sasaki, Y. et al. Production of thrombopoietin by human carcinomas and its novel isoforms. Blood 94, 1952–1960 (1999).
Article CAS PubMed Google Scholar
Josa, V. et al. Thrombocytosis and effects of IL-6 knock-out in a colitis-associated cancer model. Int. J. Mol. Sci. 21, 6218 (2020).
Article CAS PubMed PubMed Central Google Scholar
Harano, K. et al. Thrombocytosis as a prognostic factor in inflammatory breast cancer. Breast Cancer Res. Treat. 166, 819–832 (2017).
Article CAS PubMed Google Scholar
Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103–113 (2009).
Article CAS PubMed PubMed Central Google Scholar
Pucci, F. et al. PF4 promotes platelet production and lung cancer growth. Cell Rep. 17, 1764–1772 (2016).
Article CAS PubMed PubMed Central Google Scholar
Suzuki, A. et al. Thrombocytosis in patients with tumors producing colony-stimulating factor. Blood 80, 2052–2059 (1992).
Article CAS PubMed Google Scholar
Roweth, H. G. et al. Pro-inflammatory megakaryocyte gene expression in murine models of breast cancer. Sci. Adv. 8, eabo5224 (2022).
Article CAS PubMed PubMed Central Google Scholar
Egan, K. et al. Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells. PLoS One 6, e26125 (2011).
Article CAS PubMed PubMed Central Google Scholar
Miao, S. et al. Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa. Cell Death Dis. 10, 87 (2019).
Article PubMed PubMed Central Google Scholar
Calverley, D. C. et al. Significant downregulation of platelet gene expression in metastatic lung cancer. Clin. Transl. Sci. 3, 227–232 (2010).
Article CAS PubMed PubMed Central Google Scholar
Sabrkhany, S. et al. Exploration of the platelet proteome in patients with early-stage cancer. J. Proteom. 177, 65–74 (2018).
Denis, M. M. et al. Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122, 379–391 (2005).
Article CAS PubMed PubMed Central Google Scholar
Weyrich, A. S. et al. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc. Natl Acad. Sci. USA 95, 5556–5561 (1998).
Article CAS PubMed PubMed Central Google Scholar
Kerr, B. A., McCabe, N. P., Feng, W. & Byzova, T. V. Platelets govern pre-metastatic tumor communication to bone. Oncogene 32, 4319–4324 (2013).
Article CAS PubMed PubMed Central Google Scholar
Kuznetsov, H. S. et al. Identification of luminal breast cancers that establish a tumor-supportive macroenvironment defined by proangiogenic platelets and bone marrow-derived cells. Cancer Discov. 2, 1150–1165 (2012). This paper shows that platelets take up pro-angiogenic and pro-inflammatory factors in the primary tumour and release them in the metastatic site.
Article CAS PubMed PubMed Central Google Scholar
Nilsson, R. J. et al. Blood platelets contain tumor-derived RNA biomarkers. Blood 118, 3680–3683 (2011).
Article PubMed PubMed Central Google Scholar
Wang, R. et al. Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer. Proc. Natl Acad. Sci. USA 112, 14266–14271 (2015).
Article CAS PubMed PubMed Central Google Scholar
Huang, J. et al. Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role. Blood 120, 3030–3038 (2012).
Comments (0)