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metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v61i12.4003Title: Distribution of GABPB1 gene rs7181866 polymorphism in rugby playersAuthors: Yılmaz, Özlem Özge
Polat, Tolga
Eken, Başak Funda
Tuna, Gökhan
Aslan, Beste Tacal
Ulucan, KorkutKeywords: Athletic performance;Endurance;Nuclear respiration factor;Sport geneticsIssue Date: Dec-2023Publisher: NIScPR-CSIR, IndiaAbstract: Nuclear respiration factor 2 is an important respiratory factor for cellular metabolism formed by polypeptides produced by the GA binding protein transcription factor subunit alpha (GABPA) and GA binding protein transcription factor subunit beta 1 (GAPPB1) genes. A functional polymorphism on the GABPB1 gene (rs7181866, G/A) alters the cellular respiration metabolism by affecting the protein dynamics. In this context, here, we examined the distribution of GABPB1 rs718186 polymorphism in professional rugby players to see its relationship with their stamina. Twelve rugby players participated in the study. Genotyping was performed by Real-Time PCR after DNAs were isolated from blood cells using commercially available isolation kits. In our cohort, the AA genotype and the A allele were superior to the AG and GG genotypes and the G allele. There was no statistically significant difference in terms of Genotypes (p=0.9027) and allelic groups (p=0.6948) in the athlete and control groups. Studies have revealed the relationship between endurance characteristics of athletes and rs7181866 AA genotype and A allele. These studies will be an important data source for future studies in sports genetics and GAPPB1 analysis.Page(s): 929-932ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.61(12) [December 2023]

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