L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus
AbbreviationsASC
apoptosis-associated speck-like protein containing a CARD
CARD
caspase activation and recruitment domain
Cf-mtDNA
cell-free mitochondrial DNA
CVD
cardiovascular disease
DAMP
damage-associated molecular pattern
GDM
gestational diabetes mellitus
MROS
mitochondrial reactive oxygen species
NGT
normal glucose tolerant
NLRP3
NOD-, LRR- and pyrin domain-containing protein 3
PAMP
pathogen-associated molecular pattern
PBMC
peripheral blood mononuclear cell
T2DM
type 2 diabetes mellitus
VAT
visceral adipose tissue
Keywords
Gestational diabetes mellitus
Placenta
Mitochondria
Inflammation
NLRP3
Antioxidant
Data Availability
The data that support the findings in this study are available from the corresponding author upon reasonable request.
© 2023 The Authors. Published by Elsevier B.V.
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