aVita-Salute San Raffaele University

bUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan

cDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy

dOnassis Cardiac Surgery Center

eUniversity Research Institute of Maternal and Child Health and Precision Medicine and UNESCO Chair in Adolescent Healthcare, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece

Correspondence to Giacomo De Luca, MD, Vita-Salute San Raffaele University, Via Olgettina 58, Milan, Italy. Tel: +39 0226434383; e-mail: [email protected]