The present study aimed to compare the fracture resistance and marginal adaptation of endocrowns fabricated using lithium disilicate (LDS) and zirconia-reinforced lithium silicate 9ZLS) ceramics by the computer-aided design and computer-aided manufacturing (CAD/CAM) technology.

In this in vitro experimental study, 24 extracted mandibular first molars received standard endocrown preparation and were randomly assigned to two groups (n = 12) for the fabrication of endocrowns with ZLS (Suprinity) and LDS (IPS e.max CAD) ceramics. After scanning the teeth with a CAD scanner, endocrowns were designed by inLab Software version 15 (inLab SW 15) and prepared by an imes-icore 350i milling machine. The vertical marginal gap of endocrowns was measured under a stereomicroscope at three steps before and after cementation and after thermomechanical cycles. The fracture resistance of specimens was then measured by load application at a 45° angle. Mode of failure was also determined as reparable or irreparable. Data were analyzed using Pearson’s correlation test and t-test.

The mean fracture resistance of ZLS endocrowns was significantly higher than that of LDS endocrowns (P = 0.000). The reparability of ZLS endocrowns was zero, while that of LDS endocrowns was 83.33 %. The vertical marginal gap was significantly smaller in ZLS than in LDS endocrowns at all three time points (P < 0.05). Also, the marginal gap increased by cementation and thermomechanical cycles in both groups.

ZLS and LDS endocrowns both showed acceptable vertical marginal adaptation. ZLS had superior marginal adaptation and higher fracture resistance.