Factor VII (FVII) deficiency is a rare bleeding disorder with two forms: congenital/inherited and acquired type [1]. The clinical spectrum of acquired FVII deficiency varies from only a mild prolongation of the prothrombin time (PT) without clinical findings to severe, life-threatening bleeding attacks. However gastrointestinal (GI) bleeding is an unusual presentation of acquired FVII deficiency, which is shown in literature with case reports [1], [2], [3]. In this paper, we pointed out three adolescents diagnosed with inflammatory bowel disease (IBD) and acquired FVII deficiency.