Multimorbidity in Rheumatoid Arthritis: Literature Review and Future Directions

Skou ST, Mair FS, Fortin M, Guthrie B, Nunes BP, Miranda JJ, et al. Multimorbidity. Nat Rev Dis Prim. 2022;8(1):48.

Article  PubMed  Google Scholar 

Doran MF, Pond GR, Crowson CS, O’Fallon WM, Gabriel SE. Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum. 2002;46(3):625–31.

Article  PubMed  Google Scholar 

Naz SM, Symmons DP. Mortality in established rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2007;21(5):871–83.

Article  PubMed  Google Scholar 

Figus FA, Piga M, Azzolin I, McConnell R, Iagnocco A. Rheumatoid arthritis: extra-articular manifestations and comorbidities. Autoimmun Rev. 2021;20(4):102776.

Article  CAS  PubMed  Google Scholar 

Ruscitti P, Di Benedetto P, Berardicurti O, Liakouli V, Carubbi F, Cipriani P, et al. Adipocytokines in rheumatoid arthritis: the hidden link between inflammation and cardiometabolic comorbidities. J Immunol Res. 2018;2018:8410182.

Article  PubMed  PubMed Central  Google Scholar 

Yurkovich M, Avina-Zubieta JA, Thomas J, Gorenchtein M, Lacaille D. A systematic review identifies valid comorbidity indices derived from administrative health data. J Clin Epidemiol. 2015;68(1):3–14.

Article  PubMed  Google Scholar 

England BR, Thiele GM, Anderson DR, Mikuls TR. Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications. BMJ. 2018;361:k1036.

Article  PubMed  PubMed Central  Google Scholar 

Lee EE, Shin A, Lee J, Lee JH, Ha YJ, Lee YJ, et al. All-cause and cause-specific mortality of patients with rheumatoid arthritis in Korea: a nation-wide population-based study. Joint Bone Spine. 2022;89(1):105269.

Article  PubMed  Google Scholar 

Sambamoorthi U, Tan X, Deb A. Multiple chronic conditions and healthcare costs among adults. Expert Rev Pharmacoecon Outcomes Res. 2015;15(5):823–32.

Article  PubMed  PubMed Central  Google Scholar 

• Yoshida K, Lin TC, Wei MY, Malspeis S, Chu SH, Camargo CA Jr, et al. Roles of postdiagnosis accumulation of morbidities and lifestyle changes in excess total and cause-specific mortality risk in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2021;73(2):188–98. (Multimorbiidty was found to account for a substantial amount of the excess mortality seen in the RA patients.)

Article  CAS  PubMed  Google Scholar 

Crowson CS, Gunderson TM, Dykhoff HJ, Myasoedova E, Atkinson EJ, Kronzer VL, et al. Comprehensive assessment of multimorbidity burden in a population-based cohort of patients with rheumatoid arthritis. RMD Open. 2022;8(1):e002022.

Article  PubMed  PubMed Central  Google Scholar 

• England BR, Roul P, Yang Y, Sayles H, Yu F, Michaud K, et al. Burden and trajectory of multimorbidity in rheumatoid arthritis: a matched cohort study from 2006 to 2015. Ann Rheum Dis. 2021;80(3):286–92. (Described how RA patients accumulate chronic conditions at a higher rate than non-RA patients)

Article  CAS  PubMed  Google Scholar 

•• England BR, Yang Y, Roul P, Haas C, Najjar L, Sayles H, et al. Identification of multimorbidity patterns in rheumatoid arthritis through machine learning. Arthritis Care Res (Hoboken). 2023;75(2):220–30. (One of two studies to describe phenotypic patterns of multimorbidity in RA patients, compared commercial and VHA data.)

Article  CAS  PubMed  Google Scholar 

Gunderson TM, Myasoedova E, Davis JM 3rd, Crowson CS. Multimorbidity burden in rheumatoid arthritis: a population-based cohort study. J Rheumatol. 2021;48(11):1648–54.

Article  PubMed  PubMed Central  Google Scholar 

Huang YJ, Chen JS, Luo SF, Kuo CF. Comparison of indexes to measure comorbidity burden and predict all-cause mortality in rheumatoid arthritis. J Clin Med. 2021;10(22):5460.

Article  PubMed  PubMed Central  Google Scholar 

• Kronzer VL, Dykhoff HJ, Stevens MA, Myasoedova E, Davis JM 3rd, Crowson CS. Racial differences in multimorbidity and comorbidities in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2023;75(1):76–84. (Described how RA participants had an increased risk of multimorbidity and substantial multiorbidity compared to non-RA participants and that the odds of multimorbidity vary by race in non-RA patients but are similar across racial groups in RA.)

Article  CAS  PubMed  Google Scholar 

•• McLoone P, Jani BD, Siebert S, Morton FR, Canning J, Macdonald S, et al. Classification of long-term condition patterns in rheumatoid arthritis and associations with adverse health events: a UK Biobank cohort study. J Multimorbidity Comorbidity. 2023;13:26335565221148616. (Found signficant phenotypic clusters in RA and reported that RA patients with these clusters had higher rates of adverse outcomes.)

Article  Google Scholar 

Morton FR, Jani BD, Mair FS, McLoone P, Canning J, Macdonald S, et al. Association between risk, duration and cause of hospitalisations in people with rheumatoid arthritis and multimorbidity in the UK Biobank and Scottish Early Rheumatoid Arthritis (SERA) cohorts: longitudinal observational study. Semin Arthritis Rheum. 2023;58:152130.

Article  PubMed  Google Scholar 

• Armagan B, Sari A, Erden A, Kilic L, Erdat EC, Kilickap S, et al. Starting of biological disease modifying antirheumatic drugs may be postponed in rheumatoid arthritis patients with multimorbidity: single center real life results. Medicine (Baltimore). 2018;97(13):e9930. (Identified how multimorbid RA patients experience longer time to biologic therapy compared to RA patients without multimorbidity.)

Article  CAS  PubMed  Google Scholar 

• Biggioggero M, Mesina F, Favalli EG. The use of rheumatic disease comorbidity index for predicting clinical response and retention rate in a cohort of rheumatoid arthritis patients receiving tumor necrosis factor alpha inhibitors. Biomed Res Int. 2019;2019:6107217. (Described how multimorbidity serves as a predictor of poor outcomes in RA and higher rates of tumor necrosis factor alpha inhibitor failure.)

Article  PubMed  PubMed Central  Google Scholar 

Busby AD, Wason J, Pratt AG, Young A, Isaacs JD, Nikiphorou E. Predictors of poor function in RA based on two prospective UK inception cohorts. Do comorbidities matter? Rheumatology (Oxford). 2022;61(4):1563–9.

Article  PubMed  Google Scholar 

Davis JM 3rd, Myasoedova E, Gunderson TM, Crowson CS. Multimorbidity and fatigue in rheumatoid arthritis: a cross-sectional study of a population-based cohort. Rheumatol Ther. 2020;7(4):979–91.

Article  PubMed  PubMed Central  Google Scholar 

Luque Ramos A, Redeker I, Hoffmann F, Callhoff J, Zink A, Albrecht K. Comorbidities in patients with rheumatoid arthritis and their association with patient-reported outcomes: results of claims data linked to questionnaire survey. J Rheumatol. 2019;46(6):564–71.

Article  PubMed  Google Scholar 

• Ruscitti P, Di Muzio C, Conforti A, Di Cola I, Pavlych V, Navarini L, et al. Cardiometabolic multimorbidity may identify a more severe subset of rheumatoid arthritis, results from a “real-life” study. Medicine (Baltimore). 2023;102(14):e33362. (Described a cardiometabolic phenotype of multimorbidity that predicts worse outcomes in RA patients.)

Article  PubMed  Google Scholar 

Tournadre A, Pereira B, Gossec L, Soubrier M, Dougados M. Impact of comorbidities on fatigue in rheumatoid arthritis patients: results from a nurse-led program for comorbidities management (COMEDRA). Joint Bone Spine. 2019;86(1):55–60.

Article  PubMed  Google Scholar 

•• McQueenie R, Nicholl BI, Jani BD, Canning J, Macdonald S, McCowan C, et al. Patterns of multimorbidity and their effects on adverse outcomes in rheumatoid arthritis: a study of 5658 UK Biobank participants. BMJ Open. 2020;10(11):e038829. (Described the adverse outcomes in multimorbid RA patients and the synergistic effects of some comorbidites and RA on all cause mortality)

Article  PubMed  PubMed Central  Google Scholar 

Radner H. Multimorbidity in rheumatic conditions. Wien Klin Wochenschr. 2016;128(21–22):786–90.

Article  PubMed  PubMed Central  Google Scholar 

Barber CEH, Bartels CM. Making sense of multimorbidity in rheumatoid arthritis. Arthritis Care Res. 2023;75(2):207–9.

Article  Google Scholar 

Løppenthin K, Esbensen BA, Østergaard M, Ibsen R, Kjellberg J, Jennum P. Morbidity and mortality in patients with rheumatoid arthritis compared with an age- and sex-matched control population: a nationwide register study. J Comorbidity. 2019;9:2235042x19853484.

Article  Google Scholar 

van den Hoek J, Boshuizen HC, Roorda LD, Tijhuis GJ, Nurmohamed MT, van den Bos GA, et al. Mortality in patients with rheumatoid arthritis: a 15-year prospective cohort study. Rheumatol Int. 2017;37(4):487–93.

Article  PubMed  Google Scholar 

Lacaille D, Avina-Zubieta JA, Sayre EC, Abrahamowicz M. Improvement in 5-year mortality in incident rheumatoid arthritis compared with the general population—closing the mortality gap. Ann Rheum Dis. 2017;76(6):1057–63.

Article  PubMed  Google Scholar 

Listing J, Kekow J, Manger B, Burmester GR, Pattloch D, Zink A, et al. Mortality in rheumatoid arthritis: the impact of disease activity, treatment with glucocorticoids, TNFα inhibitors and rituximab. Ann Rheum Dis. 2015;74(2):415–21.

Article  CAS  PubMed  Google Scholar 

Almutairi KB, Inderjeeth CA, Preen DB, Keen HI, Nossent JC. Mortality trends among patients with rheumatoid arthritis in Western Australia. Rheumatol Ther. 2023;10(4):1021–37.

Article  PubMed  PubMed Central  Google Scholar 

Bartels CM, Ramly E, Panyard D, Lauver DR, Johnson HM, Lewicki K, et al. BP Connect Toolkit Madison, WI: University of Wisconsin—Madison School of Medicine and Public Health; 2020 [Available from: https://www.hipxchange.org/BPConnectHealth.

Bartels CM, Ramly E, Johnson HM, Lauver DR, Panyard DJ, Li Z, et al. Connecting rheumatology patients to primary care for high blood pressure: specialty clinic protocol improves follow-up and population blood pressures. Arthritis Care Res (Hoboken). 2019;71(4):461–70.

Article  PubMed  Google Scholar 

Bartels CM, Johnson L, Ramly E, Panyard DJ, Gilmore-Bykovskyi A, Johnson HM, et al. Impact of a rheumatology clinic protocol on tobacco cessation quit line referrals. Arthritis Care Res (Hoboken). 2022;74(9):1421–9.

Article  PubMed  Google Scholar 

American College of Rheumatology. Guideline for the treatment of interstitial lung disease in people with systemic autoimmune rheumatic disease 2023 [Available from: https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/bltaedebda97a351d47/interstitial-lung-disease-guideline-summary-treatment-2023.pdf. Accessed 9/30/2023

Lubell J. Teamwork guides cardio-rheumatology clinics that care for unique patient population. MDedge/Rheumatology. 2023 [Available from: https://www.mdedge.com/rheumatology/article/260726/business-medicine/teamwork-guides-cardio-rheumatology-clinics-care. Accessed 9/30/2023

Kronzer VL, Crowson CS, Sparks JA, Myasoedova E, Davis JM 3rd. Comorbidities as risk factors for rheumatoid arthritis and their accrual after diagnosis. Mayo Clin Proc. 2019;94(12):2488–98.

留言 (0)

沒有登入
gif