Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Chen P, Liu Y, Wen Y, Zhou C. Non-small cell lung cancer in China. Cancer Commun. 2022;42(10):937–70.

Article  Google Scholar 

Forde PM, Spicer J, Lu S, Provencio M, Mitsudomi T, Awad MM, et al. Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer. N Engl J Med. 2022;386(21):1973–85.

Article  PubMed  PubMed Central  CAS  Google Scholar 

O’Brien M, Paz-Ares L, Marreaud S, Dafni U, Oselin K, Havel L, et al. Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB-IIIA non-small-cell lung cancer (PEARLS/KEYNOTE-091): an interim analysis of a randomised, triple-blind, phase 3 trial. Lancet Oncol. 2022;23(10):1274–86.

Article  PubMed  CAS  Google Scholar 

Lv C, Fang W, Wu N, Jiao W, Xu S, Ma H, et al. Osimertinib as neoadjuvant therapy in patients with EGFR-mutant resectable stage II-IIIB lung adenocarcinoma (NEOS): a multicenter, single-arm, open-label phase 2b trial. Lung Cancer. 2023;178:151–6.

Article  PubMed  CAS  Google Scholar 

Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, et al. Osimertinib in resected EGFR-mutated non-small-cell lung cancer. N Engl J Med. 2020;383(18):1711–23.

Article  PubMed  CAS  Google Scholar 

Bendixen M, Jørgensen OD, Kronborg C, Andersen C, Licht PB. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol. 2016;17(6):836–44.

Article  PubMed  Google Scholar 

Yoon S, Hong WP, Joo H, Kim H, Park S, Bahk JH, et al. Long-term incidence of chronic postsurgical pain after thoracic surgery for lung cancer: a 10-year single-center retrospective study. Reg Anesth Pain Med. 2020;45(5):331–6.

Article  PubMed  Google Scholar 

Oh TK, Jeon JH, Lee JM, Kim MS, Kim JH, Cho H, et al. Investigation of opioid use and long-term oncologic outcomes for non-small cell lung cancer patients treated with surgery. PLoS One. 2017;12(7):e0181672.

Article  PubMed  PubMed Central  Google Scholar 

Hawkey CJ. COX-1 and COX-2 inhibitors. Best Pract Res Clin Gastroenterol. 2001;15(5):801–20.

Article  PubMed  CAS  Google Scholar 

Zhao M, Wang T, Hui Z. Aspirin overcomes cisplatin resistance in lung cancer by inhibiting cancer cell stemness. Thoracic Cancer. 2020;11(11):3117–25.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ogawa F, Amano H, Ito Y, Matsui Y, Hosono K, Kitasato H, et al. Aspirin reduces lung cancer metastasis to regional lymph nodes. Biomed Pharmacother. 2014;68(1):79–86.

Article  PubMed  CAS  Google Scholar 

Endo H, Yano M, Okumura Y, Kido H. Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70. Cell Death Dis. 2014;5(1):e1027.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang ZL, Fan ZQ, Jiang HD, Qu JM. Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling. Carcinogenesis. 2013;34(3):638–46.

Article  PubMed  CAS  Google Scholar 

Liu X, Hong L, Nilsson M, Hubert SM, Wu S, Rinsurongkawong W, et al. Concurrent use of aspirin with osimertinib is associated with improved survival in advanced EGFR-mutant non-small cell lung cancer. Lung Cancer. 2020;149:33–40.

Article  PubMed  Google Scholar 

Aiad M, Tahir A, Fresco K, Prenatt Z, Ramos-Feliciano K, Walia J, et al. Does the combined use of aspirin and immunotherapy result in better outcomes in non-small cell lung cancer than immunotherapy alone? Cureus. 2022;14(6):e25891.

PubMed  PubMed Central  Google Scholar 

Gadgeel SM, Ruckdeschel JC, Heath EI, Heilbrun LK, Venkatramanamoorthy R, Wozniak A. Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC). J Thorac Oncol. 2007;2(4):299–305.

Article  PubMed  Google Scholar 

Groen HJ, Sietsma H, Vincent A, Hochstenbag MM, van Putten JW, van den Berg A, et al. Randomized, placebo-controlled phase III study of docetaxel plus carboplatin with celecoxib and cyclooxygenase-2 expression as a biomarker for patients with advanced non-small-cell lung cancer: the NVALT-4 study. J Clin Oncol. 2011;29(32):4320–6.

Article  PubMed  CAS  Google Scholar 

Jiang W, Wang L, Zhang J, Shen H, Dong W, Zhang T, et al. Effects of postoperative non-steroidal anti-inflammatory drugs on long-term survival and recurrence of patients with non-small cell lung cancer. Medicine. 2018;97(39):e12442.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xu H, Zhao G, Lin J, Ye Q, Xiang J, Yan B. A combined preoperative red cell distribution width and carcinoembryonic antigen score contribute to prognosis prediction in stage I lung adenocarcinoma. World J Surg Oncol. 2023;21(1):56.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chudy-Onwugaje K, Huang WY, Su LJ, Purdue MP, Johnson CC, Wang L, et al. Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial. Cancer. 2021;127(17):3145–55.

Article  PubMed  CAS  Google Scholar 

Lim WY, Chuah KL, Eng P, Leong SS, Lim E, Lim TK, et al. Aspirin and non-aspirin non-steroidal anti-inflammatory drug use and risk of lung cancer. Lung Cancer. 2012;77(2):246–51.

Article  PubMed  Google Scholar 

McCormack VA, Hung RJ, Brenner DR, Bickeböller H, Rosenberger A, Muscat JE, et al. Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO). Cancer Causes Control. 2011;22(12):1709–20.

Article  PubMed  Google Scholar 

Ye S, Lee M, Lee D, Ha EH, Chun EM. Association of long-term use of low-dose aspirin as chemoprevention with risk of lung cancer. JAMA Netw Open. 2019;2(3):e190185.

Article  PubMed  PubMed Central  Google Scholar 

Giampieri R, Restivo A, Pusceddu V, Del Prete M, Maccaroni E, Bittoni AF, et al. The role of aspirin as antitumoral agent for heavily pretreated patients with metastatic colorectal cancer receiving capecitabine monotherapy. Clin Colorectal Cancer. 2017;16(1):38–43.

Article  PubMed  Google Scholar 

Chuang MC, Yang YH, Hsieh MJ, Lin YC, Yang TM, Chen PC, et al. The association of aspirin use with overall survival of patients with inoperable non-small cell lung cancer: a retrospective study. BMC Cancer. 2021;21(1):1257.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kanda A, Ebihara S, Okazaki T, Yasuda H, Sasaki H. Loxoprofen sodium and survival in older people with advanced non-small cell lung cancer. J Am Geriatr Soc. 2004;52(3):471–2.

Article  PubMed  Google Scholar 

Gulyas M, Mattsson JSM, Lindgren A, Ek L, Lamberg Lundström K, Behndig A, et al. COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer. Acta Oncol. 2018;57(2):244–50.

Article  PubMed  CAS  Google Scholar 

Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA. 2009;302(6):649–58.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Holmes MD, Chen WY, Li L, Hertzmark E, Spiegelman D, Hankinson SE. Aspirin intake and survival after breast cancer. J Clin Oncol. 2010;28(9):1467–72.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liao SF, Koshiol J, Huang YH, Jackson SS, Huang YH, Chan C, et al. Postdiagnosis aspirin use associated with decreased biliary tract cancer-specific mortality in a large nationwide cohort. Hepatology. 2021;74(4):1994–2006.

Article  PubMed  CAS  Google Scholar 

Walker AJ, Grainge MJ, Card TR. Aspirin and other non-steroidal anti-inflammatory drug use and colorectal cancer survival: a cohort study. Br J Cancer. 2012;107(9):1602–7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gan H, Lin L, Hu N, Yang Y, Gao Y, Pei Y, et al. Aspirin ameliorates lung cancer by targeting the miR-98/WNT1 axis. Thorac Cancer. 2019;10(4):744–50.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang Y, Lv C, Dong Y, Yang Q. Aspirin-targeted PD-L1 in lung cancer growth inhibition. Thorac Cancer. 2020;11(6):1587–93.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gai C, Yu M, Li Z, Wang Y, Ding D, Zheng J, et al. Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer. J Cell Physiol. 2020;235(4):3329–39.

Article  PubMed  CAS