Immune Priming with Spatially Fractionated Radiation Therapy

Valenza C, Rizzo G, Passalacqua MI, Boldrini L, Corti C, Trapani D, Curigliano G. Evolving treatment landscape of immunotherapy in breast cancer: current issues and future perspectives. Ther Adv Med Oncol. 2023;15:17588359221146129. https://doi.org/10.1177/17588359221146129.

Article  PubMed  PubMed Central  Google Scholar 

Sun K, Xu Y, Zhang L, Niravath P, Darcourt J, Patel T, Teh BS, Farach AM, Guerrero C, Mathur S, Sultenfuss MA, Gupta N, Schwartz MR, Haley SL, Nair S, Li X, Nguyen TTA, Butner JD, Ensor J, et al. A phase 2 trial of enhancing immune checkpoint blockade by stereotactic radiation and in situ virus gene therapy in metastatic triple-negative breast cancer. Clin Cancer Res. 2022;28(20):4392–401. https://doi.org/10.1158/1078-0432.Ccr-22-0622.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dutt S, Ahmed MM, Loo BW Jr, Strober S. Novel radiation therapy paradigms and immunomodulation: heresies and hope. Semin Radiat Oncol. 2020;30(2):194–200. https://doi.org/10.1016/j.semradonc.2019.12.006.

Article  PubMed  PubMed Central  Google Scholar 

Borzov E, Bar-Deroma R, Lutsyk M. Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas. Phys Imaging Radiat Oncol. 2022;22:63–6. https://doi.org/10.1016/j.phro.2022.04.010.

Article  PubMed  PubMed Central  Google Scholar 

•• Johnsrud AJ, Jenkins SV, Jamshidi-Parsian A, Quick CM, Galhardo EP, RPM D, Vang KB, Narayanasamy G, Makhoul I, Griffin RJ. Evidence for early stage anti-tumor immunity elicited by spatially fractionated radiotherapy-immunotherapy combinations. Radiat Res. 2020;194(6):688–97. https://doi.org/10.1667/rade-20-00065.1. This study represents an important preclinical assesssment of immune effects from combination SFRT and IT. The study suggests that systemic immune activation may be triggered by SFRT to a primary lesion and promote anti-tumor immune responses outside the treatment field.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dewan MZ, Galloway AE, Kawashima N, Dewyngaert JK, Babb JS, Formenti SC, Demaria S. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009;15(17):5379–88. https://doi.org/10.1158/1078-0432.Ccr-09-0265.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawakubo M, Demehri S, Manstein D. Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response. PLoS One. 2017;12(9):e0184852. https://doi.org/10.1371/journal.pone.0184852.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferini G, Valenti V, Tripoli A, Illari SI, Molino L, Parisi S, Cacciola A, Lillo S, Giuffrida D, Pergolizzi S. Lattice or oxygen-guided radiotherapy: what if they converge? Possible future directions in the era of immunotherapy. Cancers (Basel). 2021;13(13). https://doi.org/10.3390/cancers13133290.

Markovsky E, Budhu S, Samstein RM, Li H, Russell J, Zhang Z, Drill E, Bodden C, Chen Q, Powell SN, Merghoub T, Wolchok JD, Humm J, Deasy JO, Haimovitz-Friedman A. An antitumor immune response is evoked by partial-volume single-dose radiation in 2 murine models. Int J Radiat Oncol Biol Phys. 2019;103(3):697–708. https://doi.org/10.1016/j.ijrobp.2018.10.009.

Article  PubMed  Google Scholar 

Trappetti V, Fazzari JM, Fernandez-Palomo C, Scheidegger M, Volarevic V, Martin OA, Djonov VG. Microbeam radiotherapy-a novel therapeutic approach to overcome radioresistance and enhance anti-tumour response in melanoma. Int J Mol Sci. 2021;22(14). https://doi.org/10.3390/ijms22147755.

McKelvey KJ, Hudson AL, Back M, Eade T, Diakos CI. Radiation, inflammation and the immune response in cancer. Mamm Genome. 2018;29(11-12):843–65. https://doi.org/10.1007/s00335-018-9777-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tálas M, Szolgay E, Várterész V, Koczkás G. Influence of acute and fractional X-irradiation on induction of interferon in vivo. Arch Gesamte Virusforsch. 1972;38(2):143–8. https://doi.org/10.1007/bf01249664.

Article  PubMed  Google Scholar 

Fujiwara N, Kobayashi K. Macrophages in inflammation. Curr Drug Targets Inflamm Allergy. 2005;4(3):281–6. https://doi.org/10.2174/1568010054022024.

Article  CAS  PubMed  Google Scholar 

Santana MA, Esquivel-Guadarrama F. Cell biology of T cell activation and differentiation. Int Rev Cytol. 2006;250:217–74. https://doi.org/10.1016/s0074-7696(06)50006-3.

Article  CAS  PubMed  Google Scholar 

Weichselbaum RR, Liang H, Deng L, Fu YX. Radiotherapy and immunotherapy: a beneficial liaison? Nat Rev Clin Oncol. 2017;14(6):365–79. https://doi.org/10.1038/nrclinonc.2016.211.

Article  CAS  PubMed  Google Scholar 

Pajonk F, Vlashi E, McBride WH. Radiation resistance of cancer stem cells: the 4 R’s of radiobiology revisited. Stem Cells. 2010;28(4):639–48. https://doi.org/10.1002/stem.318.

Article  CAS  PubMed  Google Scholar 

Moghaddasi L, Reid P, Bezak E, Marcu LG. Radiobiological and treatment-related aspects of spatially fractionated radiotherapy. Int J Mol Sci. 2022;23(6). https://doi.org/10.3390/ijms23063366.

Qiu B, Aili A, Xue L, Jiang P, Wang J. Advances in radiobiology of stereotactic ablative radiotherapy. Front Oncol. 2020;10:1165. https://doi.org/10.3389/fonc.2020.01165.

Article  PubMed  PubMed Central  Google Scholar 

Nivet A, Schlienger M, Clavère P, Huguet F. Effects of high-dose irradiation on vascularization: physiopathology and clinical consequences. Cancer Radiother. 2019;23(2):161–7. https://doi.org/10.1016/j.canrad.2018.05.009.

Article  CAS  PubMed  Google Scholar 

Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, et al. Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell. 2023;41(5):950–69.e6. https://doi.org/10.1016/j.ccell.2023.04.001.

Article  CAS  PubMed  Google Scholar 

Demaria S, Coleman CN, Formenti SC. Radiotherapy: changing the game in immunotherapy. Trends Cancer. 2016;2(6):286–94. https://doi.org/10.1016/j.trecan.2016.05.002.

Article  PubMed  PubMed Central  Google Scholar 

Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, Mu Z, Rasalan T, Adamow M, Ritter E, Sedrak C, Jungbluth AA, Chua R, Yang AS, Roman RA, Rosner S, Benson B, Allison JP, Lesokhin AM, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366(10):925–31. https://doi.org/10.1056/NEJMoa1112824.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Massaccesi M, Boldrini L, Romano A, Rossi E, Schinzari G, Lepre E, Gambacorta MA, Valentini V. Unconventional radiotherapy to enhance immunotherapy efficacy in bulky tumors: a case report. Immunotherapy. 2021;13(18):1457–63. https://doi.org/10.2217/imt-2020-0289. This is a relevant case report highlighting the combination of immune-sparing partially ablative irradiation and immunotherapy. The observed response suggests a synergistic effect between heterogeneous dose radiation and immunotherapy.

Article  CAS  PubMed  Google Scholar 

Daguenet E, Louati S, Wozny AS, Vial N, Gras M, Guy JB, Vallard A, Rodriguez-Lafrasse C, Magné N. Radiation-induced bystander and abscopal effects: important lessons from preclinical models. Br J Cancer. 2020;123(3):339–48. https://doi.org/10.1038/s41416-020-0942-3.

Article  PubMed  PubMed Central  Google Scholar 

Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells. Proc Natl Acad Sci U S A. 2001;98(2):473–8. https://doi.org/10.1073/pnas.98.2.473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reynders K, Illidge T, Siva S, Chang JY, De Ruysscher D. The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev. 2015;41(6):503–10. https://doi.org/10.1016/j.ctrv.2015.03.011.

Article  PubMed  PubMed Central  Google Scholar 

Sun R, Sbai A, Ganem G, Boudabous M, Collin F, Marcy PY, Doglio A, Thariat J. Non-targeted effects (bystander, abscopal) of external beam radiation therapy: an overview for the clinician. Cancer Radiother. 2014;18(8):770–8. https://doi.org/10.1016/j.canrad.2014.08.004.

Article  CAS  PubMed  Google Scholar 

Necchi A, Raggi D, Gallina A, Ross JS, Farè E, Giannatempo P, Marandino L, Colecchia M, Lucianò R, Bianchi M, Colombo R, Salonia A, Gandaglia G, Fossati N, Bandini M, Pederzoli F, Capitanio U, Montorsi F, de Jong JJ, et al. Impact of molecular subtyping and immune infiltration on pathological response and outcome following neoadjuvant pembrolizumab in muscle-invasive bladder cancer. Eur Urol. 2020;77(6):701–10. https://doi.org/10.1016/j.eururo.2020.02.028.

Article  CAS  PubMed  Google Scholar 

Seiler R, Ashab HAD, Erho N, van Rhijn BWG, Winters B, Douglas J, Van Kessel KE, Fransen van de Putte EE, Sommerlad M, Wang NQ, Choeurng V, Gibb EA, Palmer-Aronsten B, Lam LL, Buerki C, Davicioni E, Sjödahl G, Kardos J, Hoadley KA, et al. Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy. Eur Urol. 2017;72(4):544–54. https://doi.org/10.1016/j.eururo.2017.03.030.

Article  CAS  PubMed  Google Scholar 

Kardos J, Chai S, Mose LE, Selitsky SR, Krishnan B, Saito R, Iglesia MD, Milowsky MI, Parker JS, Kim WY, Vincent BG. Claudin-low bladder tumors are immune infiltrated and actively immune suppressed. JCI Insight. 2016;1(3):e85902. https://doi.org/10.1172/jci.insight.85902.

Article  PubMed  PubMed Central  Google Scholar 

Efstathiou JA, Mouw KW, Gibb EA, Liu Y, Wu CL, Drumm MR, da Costa JB, du Plessis M, Wang NQ, Davicioni E, Feng FY, Seiler R, Black PC, Shipley WU, Miyamoto DT. Impact of immune and stromal infiltration on outcomes following bladder-sparing trimodality therapy for muscle-invasive bladder cancer. Eur Urol. 2019;76(1):59–68. https://doi.org/10.1016/j.eururo.2019.01.011.

Article  PubMed  PubMed Central 

留言 (0)

沒有登入
gif