From the Department of Biomedical Engineering, University of Virginia, Charlottesville, VA (Y.H., Y.X., J.A.H.); Philips Research North America, Cambridge, MA (E.B.H.); Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA (L.Y., Z.H.I., E.W.K., B.W.); and Division of Cardiovascular Medicine, Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia, Charlottesville, VA (A.L.K.).

Received for publication March 10, 2023; and accepted for publication, after revision, May 20, 2023.

Conflicts of interest and sources of funding: A.L.K. declares support to his UVA laboratory from a subcontract via a Virginia Catalyst program grant to SoundPipe Therapeutics. The study described in this manuscript is unrelated to the subcontract project. J.A.H. is a partial owner of SoundPipe Therapeutics. The scope of SoundPipe's business has no intersection with the original content of this article. No other authors have conflicts. This work was supported by the National Institutes of Health R01 HL132395, R01 HL162895, and S10 1S10RR027333-01 for the Vevo 2100 scanner.

Correspondence to: John A. Hossack, PhD, Department of Biomedical Engineering, University of Virginia, Room 2121, 415 Lane Rd, MR5 Bldg, Charlottesville, VA 22908. E-mail: [email protected].

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