Minor GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells

Wang H, Chuhjo T, Yasue S, Omine M, Nakao S. Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome. Blood. 2002;100:3897–902.

Article  CAS  PubMed  Google Scholar 

Sugimori C, Mochizuki K, Qi Z, Sugimori N, Ishiyama K, Kondo Y, et al. Origin and fate of blood cells deficient in glycosylphosphatidylinositol-anchored protein among patients with bone marrow failure. Br J Haematol. 2009;147:102–12.

Article  CAS  PubMed  Google Scholar 

Fattizzo B, Ireland R, Dunlop A, Yallop D, Kassam S, Large J, et al. Clinical and prognostic significance of small paroxysmal nocturnal hemoglobinuria clones in myelodysplastic syndrome and aplastic anemia. Leukemia. 2021;35:3223–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Okamoto M, Shichishima T, Noji H, Ikeda K, Nakamura A, Akutsu K, et al. High frequency of several PIG-A mutations in patients with aplastic anemia and myelodysplastic syndrome. Leukemia. 2006;20:627–34.

Article  CAS  PubMed  Google Scholar 

Clemente MJ, Przychodzen B, Hirsch CM, Nagata Y, Bat T, Wlodarski MW, et al. Clonal PIGA mosaicism and dynamics in paroxysmal nocturnal hemoglobinuria. Leukemia. 2018;32:2507–11.

Article  CAS  PubMed Central  Google Scholar 

Jeong D, Park HS, Kim SM, Im K, Yun J, Lee YE, et al. Ultradeep sequencing analysis of paroxysmal nocturnal hemoglobinuria clones detected by flow cytometry: PIG mutation in small PNH clones. Am J Clin Pathol. 2021;156:72–85.

Article  CAS  Google Scholar 

Katagiri T, Kawamoto H, Nakakuki T, Ishiyama K, Okada-Hatakeyama M, Ohtake S, et al. Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages. Stem Cells. 2013;31:536–46.

Article  CAS  PubMed  Google Scholar 

Araten DJ, Nafa K, Pakdeesuwan K, Luzzatto L. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals. Proc Natl Acad Sci USA. 1999;96:5209–14.

Article  CAS  PubMed Central  Google Scholar 

Hu R, Mukhina GL, Piantadosi S, Barber JP, Jones RJ, Brodsky RA. PIG-A mutations in normal hematopoiesis. Blood. 2005;105:3848–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hosokawa K, Sugimori C, Ishiyama K, Takamatsu H, Noji H, Shichishima T, et al. Establishment of a flow cytometry assay for detecting paroxysmal nocturnal hemoglobinuria-type cells specific to patients with bone marrow failure. Ann Hematol. 2018;97:2289–97.

Article  CAS  PubMed  Google Scholar 

Pu JJ, Hu R, Mukhina GL, Carraway HE, McDevitt MA, Brodsky RA. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells. Haematologica. 2012;97:1225–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gargiulo L, Papaioannou M, Sica M, Talini G, Chaidos A, Richichi B, et al. Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria. Blood. 2013;121:2753–61.

Article  CAS  PubMed  Google Scholar 

Dingli D, Traulsen A, Pacheco JM. Compartmental architecture and dynamics of hematopoiesis. PLoS One. 2007;2:e345.

Article  PubMed  PubMed Central  Google Scholar 

Hattori H, Machii T, Ueda E, Shibano M, Kageyama T, Kitani T. Increased frequency of somatic mutations at glycophorin A loci in patients with aplastic anaemia, myelodysplastic syndrome and paroxysmal nocturnal haemoglobinuria. Br J Haematol. 1997;98:384–91.

Article  CAS  PubMed  Google Scholar 

Araten DJ, Zamechek L, Halverson G. No evidence of hypermutability in red cells from patients with paroxysmal nocturnal hemoglobinuria using the XK gene. Haematologica. 2014;99:e142–4.

Article  PubMed  PubMed Central  Google Scholar 

Spencer Chapman M, Ranzoni AM, Myers B, Williams N, Coorens THH, Mitchell E, et al. Lineage tracing of human development through somatic mutations. Nature. 2021;595:85–90.

Article  CAS  PubMed  Google Scholar 

Wong WH, Tong S, Druley TE. Error-corrected sequencing of cord bloods identifies pediatric AML-associated clonal hematopoiesis. Blood. 2017;130:2687.

Google Scholar 

留言 (0)

沒有登入
gif