Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis

Alinaghi F, Bennike NH, Egeberg A, Thyssen JP, Johansen JD. Prevalence of contact allergy in the general population: a systematic review and meta-analysis. Contact Dermatitis. 2019;80:77–85.

Article  CAS  PubMed  Google Scholar 

Lim HW, Collins SAB, Resneck JS Jr, et al. The burden of skin disease in the United States. J Am Acad Dermatol. 2017;76:958-972.e2.

Article  PubMed  Google Scholar 

Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. 2000;9:165–9.

Article  CAS  PubMed  Google Scholar 

Humeniuk P, Dubiela P, Hoffmann-Sommergruber K. Dendritic cells and their role in allergy: uptake, proteolytic processing and presentation of allergens. Int J Mol Sci. 2017. https://doi.org/10.3390/ijms18071491.

Article  PubMed  PubMed Central  Google Scholar 

Kalish RS. Recent developments in the pathogenesis of allergic contact dermatitis. Arch Dermatol. 1991;127:1558–63.

Article  CAS  PubMed  Google Scholar 

Brar KK. A review of contact dermatitis. Ann Allergy Asthma Immunol. 2021;126:32–9.

Article  PubMed  Google Scholar 

Di Agosta E, Salvati L, Corazza M, et al. Quality of life in patients with allergic and immunologic skin diseases: in the eye of the beholder. Clin Mol Allergy. 2021;19:26.

Article  PubMed  PubMed Central  Google Scholar 

Lachapelle J-M. L’historique des patch-tests. Ann Dermatol Venereol. 2009;136:575–7.

Article  PubMed  Google Scholar 

Johansen JD, Aalto-Korte K, Agner T, et al. European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice. Contact Dermatitis. 2015;73:195–221.

Article  PubMed  Google Scholar 

Veverka KK, Davis MDP. Dubiously doubtful: an exploration of the literature concerning doubtful, macular erythema, “?+”, and “+/−” Patch Test Reactions. Dermatitis. 2020;31:36–41.

Article  PubMed  Google Scholar 

Davis MDP, Yiannias JA. Should macular erythema reactions be counted as positive allergic patch-test reactions? Dermatitis. 2006;17:12–4.

Article  PubMed  Google Scholar 

Ophaug S, Schwarzenberger K. Pitfalls in patch testing: minimizing the risk of avoidable false-negative reactions. Dermatol Clin. 2020;38:293–300.

Article  CAS  PubMed  Google Scholar 

Sachs B, Fatangare A, Sickmann A, Glässner A. Lymphocyte transformation test: history and current approaches. J Immunol Methods. 2021;493:113036.

Article  CAS  PubMed  Google Scholar 

Mayorga C, Ebo DG, Lang DM, Pichler WJ, Sabato V, Park MA, Makowska J, Atanaskovic-Markovic M, Bonadonna P, Jares E. Controversies in drug allergy: In vitro testing. J Allergy Clin Immunol. 2019;143:56–65.

Article  CAS  PubMed  Google Scholar 

Schwarz A, Philippsen R, Schwarz T. Mouse models of allergic contact dermatitis: practical aspects. J Invest Dermatol. 2023;143:888–92.

Article  CAS  PubMed  Google Scholar 

Cumberbatch M, Kimber I. Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization. Immunology. 1995;84:31–5.

CAS  PubMed  PubMed Central  Google Scholar 

Kabashima K, Sakata D, Nagamachi M, Miyachi Y, Inaba K, Narumiya S. Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat Med. 2003;9:744–9.

Article  CAS  PubMed  Google Scholar 

Honda T, Egawa G, Grabbe S, Kabashima K. Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis. J Invest Dermatol. 2013;133:303–15.

Article  CAS  PubMed  Google Scholar 

Xu H, DiIulio NA, Fairchild RL. T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells. J Exp Med. 1996;183:1001–12.

Article  CAS  PubMed  Google Scholar 

Larson RP, Zimmerli SC, Comeau MR, Itano A, Omori M, Iseki M, Hauser C, Ziegler SF. Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses. J Immunol. 2010;184:2974–84.

Article  CAS  PubMed  Google Scholar 

Novak-Bilić G, Vučić M, Japundžić I, Meštrović-Štefekov J, Stanić-Duktaj S, Lugović-Mihić L. Irritant and allergic contact dermatitis - skin lesion characteristics. Acta Clin Croat. 2018;57:713–20.

PubMed  PubMed Central  Google Scholar 

Diepgen TL, Ofenloch RF, Bruze M, Bertuccio P, Cazzaniga S, Coenraads P-J, Elsner P, Goncalo M, Svensson Å, Naldi L. Prevalence of contact allergy in the general population in different European regions. Br J Dermatol. 2016;174:319–29.

Article  CAS  PubMed  Google Scholar 

Meller S, Lauerma AI, Kopp FM, et al. Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference. J Allergy Clin Immunol. 2007;119:1470–80.

Article  CAS  PubMed  Google Scholar 

Kamsteeg M, Jansen PAM, Van Vlijmen-Willems IMJJ, Van Erp PEJ, Rodijk-Olthuis D, Van Der Valk PG, Feuth T, Zeeuwen PLJM, Schalkwijk J. Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis. Br J Dermatol. 2010;162:568–78.

Article  CAS  PubMed  Google Scholar 

Riis JL, Johansen C, Vestergaard C, Bech R, Kragballe K, Iversen L. Kinetics and differential expression of the skin-related chemokines CCL27 and CCL17 in psoriasis, atopic dermatitis and allergic contact dermatitis. Exp Dermatol. 2011;20:789–94.

Article  CAS  PubMed  Google Scholar 

Pedersen MB, Skov L, Menné T, Johansen JD, Olsen J. Gene expression time course in the human skin during elicitation of allergic contact dermatitis. J Invest Dermatol. 2007;127:2585–95.

Article  CAS  PubMed  Google Scholar 

Förster R, Davalos-Misslitz AC, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol. 2008;8:362–71.

Article  PubMed  Google Scholar 

Wisgrill L, Werner P, Jalonen E, Berger A, Lauerma A, Alenius H, Fyhrquist N. Integrative transcriptome analysis deciphers mechanisms of nickel contact dermatitis. Allergy. 2021;76:804–15.

Article  CAS  PubMed  Google Scholar 

• Schmidt M, Raghavan B, Müller V, et al. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol. 2010;11:814–9. This study showed the mechanism of nickel directly triggering pattern recognition receptor signaling through TLR4 to drive pro-inflammatory responses, which is species-specific and requires non-conserved histidine residues H456 and H458 in human TLR4.

Article  CAS  PubMed  Google Scholar 

Shornick LP, De Togni P, Mariathasan S, Goellner J, Strauss-Schoenberger J, Karr RW, Ferguson TA, Chaplin DD. Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone. J Exp Med. 1996;183:1427–36.

Article  CAS  PubMed  Google Scholar 

Watanabe H, Gaide O, Pétrilli V, Martinon F, Contassot E, Roques S, Kummer JA, Tschopp J, French LE. Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol. 2007;127:1956–63.

Article  CAS  PubMed  Google Scholar 

Martynova E, Rizvanov A, Urbanowicz RA, Khaiboullina S. Inflammasome contribution to the activation of Th1, Th2, and Th17 immune responses. Front Microbiol. 2022;13: 851835.

Article  PubMed  PubMed Central  Google Scholar 

van de Veerdonk FL, Joosten LAB, Shaw PJ, Smeekens SP, Malireddi RKS, van der Meer JWM, Kullberg B-J, Netea MG, Kanneganti T-D. The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis. Eur J Immunol. 2011;41:2260–8.

Article  PubMed  PubMed Central  Google Scholar 

• Dhingra N, Shemer A, Correa da Rosa J, et al. Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. J Allergy Clin Immunol. 2014;134:362–72. This study showed that while allergic contact dermatitis can look similar by visual examination, the underlying immune pathways (Th1, Th2, Th17) can differ between allergens.

Article  CAS  PubMed  Google Scholar 

Pavel AB, Del Duca E, Cheng J, et al. Delayed type hypersensitivity reactions to various allergens may differently model inflammatory skin diseases. Allergy. 2023;78:178–91.

Article  CAS  PubMed  Google Scholar 

Mehta H, Jack C, Maari C, Proulx ÉS-C, Bissonnette R, Ramirez-Valle F, Sarfati M. Oral prednisone regulates human skin T cells in delayed-type hypersensitivity reaction elicited by diphencyprone. Allergy. 2023. https://doi.org/10.1111/all.15764.

Article  PubMed  Google Scholar 

• Fortino V, Wisgrill L, Werner P, et al. Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis. Proc Natl Acad Sci USA. 2020;117:33474–85. This was one of two recent studies that showed the potential of using machine-learning approaches on gene expression analyses to identify potential biomarkers to distinguish allergic and irritant contact dermatitis in human skin. More datasets are needed to validate the findings.

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