Conceptualization, F Carta, CT Supuran and S Carradori; data analysis, I D’Agostino, F Carta, R Grande and S Carradori; formal analysis, G Benito, I D’Agostino, M Fantacuzzi, M Agamennone, C Capasso and V Puca; writing and original draft preparation, G Benito, I D’Agostino, M Fantacuzzi and R Grande. All authors have read and agreed to the published version of the manuscript.