Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science. 2011;331(6024):1559–64.

Article  CAS  PubMed  Google Scholar 

Shi Y, Huang X, Du Z, Tan J. Analysis of single-cell RNA-sequencing data identifies a hypoxic tumor subpopulation associated with poor prognosis in triple-negative breast cancer. Math Biosci Eng. 2022;19(6):5793–812.

Article  PubMed  Google Scholar 

Zhu N, Gu L, Jia J, Wang X, Wang L, Yang M, Yuan W. Endothelin-1 triggers human peritoneal mesothelial cells’ proliferation via ERK1/2-Ets-1 signaling pathway and contributes to endothelial cell angiogenesis. J Cell Biochem. 2019;120(3):3539–46.

Article  CAS  PubMed  Google Scholar 

Katanasaka Y, Kodera Y, Kitamura Y, Morimoto T, Tamura T, Koizumi F. Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma. Mol Cancer. 2013;12:31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee CK, Jeong SH, Jang C, Bae H, Kim YH, Park I, Kim SK, Koh GY. Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation. Science. 2019;363(6427):644–9.

Article  CAS  PubMed  Google Scholar 

Commerford CD, Dieterich LC, He Y, Hell T, Montoya-Zegarra JA, Noerrelykke SF, Russo E, Röcken M, Detmar M. Mechanisms of tumor-induced lymphovascular niche formation in draining lymph nodes. Cell Rep. 2018;25(13):3554-3563.e3554.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cochran AJ, Wen DR, Morton DL. Management of the regional lymph nodes in patients with cutaneous malignant melanoma. World J Surg. 1992;16(2):214–21.

Article  CAS  PubMed  Google Scholar 

Jamieson GG, Lamb PJ, Thompson SK. The role of lymphadenectomy in esophageal cancer. Ann Surg. 2009;250(2):206–9.

Article  PubMed  Google Scholar 

Li YL, Chen CH, Chen JY, Lai YS, Wang SC, Jiang SS, Hung WC. Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes. Oncoimmunology. 2020;9(1):1830513.

Article  PubMed  PubMed Central  Google Scholar 

Liu YM, Ge JY, Chen YF, Liu T, Chen L, Liu CC, Ma D, Chen YY, Cai YW, Xu YY, et al. Combined single-cell and spatial transcriptomics reveal the metabolic evolvement of breast cancer during early dissemination. Adv Sci (Weinh). 2023:e2205395.

Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre A, Alshetaiwi H, et al. Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat Cell Biol. 2020;22(3):310–20.

Article  CAS  PubMed  Google Scholar 

Pegoraro S, Ros G, Piazza S, Sommaggio R, Ciani Y, Rosato A, Sgarra R, Del Sal G, Manfioletti G. HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness. Oncotarget. 2013;4(8):1293–308.

Article  PubMed  PubMed Central  Google Scholar 

Nakayama J, Matsunaga H, Arikawa K, Yoda T, Hosokawa M, Takeyama H, Yamamoto Y, Semba K. Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts. Dis Model Mech. 2022. https://doi.org/10.1242/dmm.049538.

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Ren D, Guo L, Wang L, Wu S, Lin C, Ye L, Zhu J, Li J, Song L, et al. Thymosin beta 10 is a key regulator of tumorigenesis and metastasis and a novel serum marker in breast cancer. Breast Cancer Res. 2017;19(1):15.

Article  PubMed  PubMed Central  Google Scholar 

Ashraf Y, Mansouri H, Laurent-Matha V, Alcaraz LB, Roger P, Guiu S, Derocq D, Robin G, Michaud HA, Delpech H, et al. Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies. J Immunother Cancer. 2019;7(1):29.

Article  PubMed  PubMed Central  Google Scholar 

Balestrieri K, Kew K, McDaniel M, Ramez M, Pittman HK, Murray G, Vohra NA, Verbanac KM. Proteomic identification of tumor- and metastasis-associated galectin-1 in claudin-low breast cancer. Biochim Biophys Acta Gen Subj. 2021;1865(2):129784.

Article  CAS  PubMed  Google Scholar 

Ebright RY, Lee S, Wittner BS, Niederhoffer KL, Nicholson BT, Bardia A, Truesdell S, Wiley DF, Wesley B, Li S, et al. Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis. Science. 2020;367(6485):1468–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munshi N, Agalioti T, Lomvardas S, Merika M, Chen G, Thanos D. Coordination of a transcriptional switch by HMGI(Y) acetylation. Science. 2001;293(5532):1133–6.

Article  CAS  PubMed  Google Scholar 

Yomtoubian S, Lee SB, Verma A, Izzo F, Markowitz G, Choi H, Cerchietti L, Vahdat L, Brown KA, Andreopoulou E, et al. Inhibition of EZH2 catalytic activity selectively targets a metastatic subpopulation in triple-negative breast cancer. Cell Rep. 2020;30(3):755-770.e756.

Article  CAS  PubMed  Google Scholar 

Duan D, Shang M, Han Y, Liu J, Liu J, Kong SH, Hou J, Huang B, Lu J, Zhang Y. EZH2-CCF-cGAS axis promotes breast cancer metastasis. Int J Mol Sci. 2022;23(3):1788.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belletti B, Baldassarre G. Stathmin: a protein with many tasks. New biomarker and potential target in cancer. Expert Opin Ther Targets. 2011;15(11):1249–66.

Article  CAS  PubMed  Google Scholar 

Sgubin M, Pegoraro S, Pellarin I, Ros G, Sgarra R, Piazza S, Baldassarre G, Belletti B, Manfioletti G. HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel. Cell Death Dis. 2022;13(5):429.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang T, Zhou T, Fu F, Han Y, Li Y, Yuan M. HMGA1 as a potential prognostic and therapeutic biomarker in breast cancer. Dis Mark. 2022;2022:7466555.

Google Scholar 

Xu K, Zhang W, Wang C, Hu L, Wang R, Wang C, Tang L, Zhou G, Zou B, Xie H, et al. Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancer. Hum Mol Genet. 2021;30(5):370–80.

Article  CAS  PubMed  Google Scholar 

Tsai RK, Discher DE. Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J Cell Biol. 2008;180(5):989–1003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu K, Wang R, Chen Q, Liu Y, Li X, Mao L, Wang C, Gao F, Hu L, Xie H, et al. Microenvironment components and spatially resolved single-cell transcriptome atlas of breast cancer metastatic axillary lymph nodes. Acta Biochim Biophys Sin (Shanghai). 2022;54(9):1336–48.

CAS  PubMed  Google Scholar 

Ohashi R, Yanagihara K, Namimatsu S, Sakatani T, Takei H, Naito Z, Shimizu A. Osteoclast-like giant cells in invasive breast cancer predominantly possess M2-macrophage phenotype. Pathol Res Pract. 2018;214(2):253–8.

Article  CAS  PubMed  Google Scholar 

Cai G, Simsir A, Cangiarella J. Invasive mammary carcinoma with osteoclast-like giant cells diagnosed by fine-needle aspiration biopsy: review of the cytologic literature and distinction from other mammary lesions containing giant cells. Diagn Cytopathol. 2004;30(6):396–400.

Article  PubMed  Google Scholar 

Dioscoridi L, Bisogni D, Freschi G. Hepatocellular carcinoma with osteoclast-like giant cells: report of the seventh case in the literature. Case Rep Surg. 2015;2015:836105.

PubMed  PubMed Central  Google Scholar 

Hatano Y, Nakahama K, Isobe M, Morita I. Tumor associated osteoclast-like giant cells promote tumor growth and lymphangiogenesis by secreting vascular endothelial growth factor-C. Biochem Biophys Res Commun. 2014;446(1):149–54.

Article  CAS  PubMed  Google Scholar 

Stratton A, Plackett TP, Belnap CM, Lin-Hurtubise KM. Infiltrating mammary carcinoma with osteoclast-like giant cells. Hawaii Med J. 2010;69(12):284–5.

PubMed  PubMed Central  Google Scholar 

Asselin-Labat ML, Vaillant F, Sheridan JM, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, et al. Control of mammary stem cell function by steroid hormone signalling. Nature. 2010;465(7299):798–802.

Article  CAS  PubMed  Google Scholar 

Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 2010;468(7320):98–102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cyrta J, Benoist C, Masliah-Planchon J, Vieira AF, Pierron G, Fuhrmann L, Richardot C, Caly M, Leclere R, Mariani O, et al. Breast carcinomas with osteoclast-like giant cells: a comprehensive clinico-pathological and molecular portrait and evidence of RANK-L expression. Mod Pathol. 2022;35(11):1624–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gonzalez-Suarez E, Jacob AP, Jones J, Miller R, Roudier-Meyer MP, Erwert R, Pinkas J, Branstetter D, Dougall WC. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature. 2010;468(7320):103–7.

Article  CAS  PubMed