Abedi F, Hayes AW, Reiter R, Karimi G. Acute lung injury: the therapeutic role of rho kinase inhibitors. Pharmacol Res. 2020;155:104736.

Article  CAS  PubMed  Google Scholar 

Kurdowska A, Noble JM, Steinberg KP, Ruzinski JT, Hudson LD, Martin TR. Anti-interleukin 8 autoantibody: interleukin 8 complexes in the acute respiratory distress syndrome. Relationship between the complexes and clinical disease activity. Am J Respir Crit Care Med. 2001;163:463–8.

Article  CAS  PubMed  Google Scholar 

Maneta-Peyret L, Kitsiouli E, Lekka M, Nakos G, Cassagne C. Autoantibodies to lipids in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Crit Care Med. 2001;29:1950–4.

Article  CAS  PubMed  Google Scholar 

Kurdowska A, Noble JM, Grant IS, Robertson CR, Haslett C, Donnelly SC. Anti-interleukin-8 autoantibodies in patients at risk for acute respiratory distress syndrome. Crit Care Med. 2002;30:2335–7.

Article  CAS  PubMed  Google Scholar 

Ward PA, Fattahi F, Bosmann M. New Insights into Molecular Mechanisms of Immune Complex-Induced Injury in Lung. Front Immunol. 2016;7:86.

Article  PubMed  PubMed Central  Google Scholar 

Mulligan MS, Varani J, Dame MK, Lane CL, Smith CW, Anderson DC, Ward PA. Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest. 1991;88:1396–406.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mulligan MS, Vaporciyan AA, Miyasaka M, Tamatani T, Ward PA. Tumor necrosis factor alpha regulates in vivo intrapulmonary expression of ICAM-1. Am J Pathol. 1993;142:1739–49.

CAS  PubMed  PubMed Central  Google Scholar 

Gao H, Neff T, Ward PA. Regulation of lung inflammation in the model of IgG immune-complex injury. Annu Rev Pathol. 2006;1:215–42.

Article  CAS  PubMed  Google Scholar 

Beavo JA, Brunton LL. Cyclic nucleotide research -- still expanding after half a century. Nat Rev Mol Cell Biol. 2002;3:710–8.

Article  CAS  PubMed  Google Scholar 

Teixeira MM, Gristwood RW, Cooper N, Hellewell PG. Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol Sci. 1997;18:164–71.

Article  CAS  PubMed  Google Scholar 

Kamenetsky M, Middelhaufe S, Bank EM, Levin LR, Buck J, Steegborn C. Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol. 2006;362:623–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 1998;396:474–7.

Article  PubMed  Google Scholar 

Zieba BJ, Artamonov MV, Jin L, Momotani K, Ho R, Franke AS, Neppl RL, Stevenson AS, Khromov AS, Chrzanowska-Wodnicka M, Somlyo AV. The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. J Biol Chem. 2011;286:16681–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walsh DA, Perkins JP, Krebs EG. An adenosine 3’,5’-monophosphate-dependant protein kinase from rabbit skeletal muscle. J Biol Chem. 1968;243:3763–5.

Article  CAS  PubMed  Google Scholar 

Ghosh M, Garcia-Castillo D, Aguirre V, Golshani R, Atkins CM, Bramlett HM, Dietrich WD, Pearse DD. Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury. Glia. 2012;60:1839–59.

Article  PubMed  PubMed Central  Google Scholar 

Ariga M, Neitzert B, Nakae S, Mottin G, Bertrand C, Pruniaux MP, Jin SL, Conti M. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J Immunol. 2004;173:7531–8.

Article  CAS  PubMed  Google Scholar 

Susuki-Miyata S, Miyata M, Lee BC, Xu H, Kai H, Yan C, Li JD. Cross-talk between PKA-Cbeta and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi. Proc Natl Acad Sci U S A. 2015;112:E1800–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Song S, Hu Z, Zhang Z, Li Y, Yan C, Li Z, Tang H. Activation of Epac alleviates inflammation and vascular leakage in LPS-induced acute murine lung injury. Biomed Pharmacother. 2017;96:1127–36.

Article  CAS  PubMed  Google Scholar 

Wang T, Liu C, Pan LH, Liu Z, Li CL, Lin JY, He Y, Xiao JY, Wu S, Qin Y, Li Z, Lin F. Inhibition of p38 MAPK mitigates Lung Ischemia Reperfusion Injury by reducing blood-air barrier hyperpermeability. Front Pharmacol. 2020;11:569251.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang J, Huang K, Xu S, Garcia JGN, Wang C, Cai H. Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction. Redox Biol. 2020;36:101638.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hui Z, Jie H, Fan GH. Expression of DUSP12 reduces lung vascular endothelial cell damage in a murine model of Lipopolysaccharide-Induced Acute Lung Injury via the apoptosis Signal-Regulating kinase 1 (ASK1)-Jun N-Terminal kinase activation (JNK) pathway. Med Sci Monit. 2021;27:e930429.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan C, Zhang L, Yang L, Zhang Q, Wang X. C/EBPgamma is a critical negative regulator of LPS-/IgG immune complex-induced acute lung injury through the downregulation of C/EBPbeta-/C/EBPdelta-dependent C/EBP transcription activation. FASEB J. 2020;34:13696–710.

Article  CAS  PubMed  Google Scholar 

Yan C, Chen J, Ding Y, Zhou Z, Li B, Deng C, Yuan D, Zhang Q, Wang X. The crucial role of PPARgamma-Egr-1-Pro-Inflammatory Mediators Axis in IgG Immune Complex-Induced Acute Lung Injury. Front Immunol. 2021;12:634889.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan C, Wu M, Cao J, Tang H, Zhu M, Johnson PF, Gao H. Critical role for CCAAT/enhancer-binding protein beta in immune complex-induced acute lung injury. J Immunol. 2012;189:1480–90.

Article  CAS  PubMed  Google Scholar 

Yan C, Liu Y, Gao H, Wang X. Suppressors of cytokine signaling 3 is essential for FcgammaR-mediated inflammatory response via enhancing CCAAT/enhancer-binding protein delta transcriptional activity in macrophages. Exp Cell Res. 2015;337:120–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Konrad S, Ali SR, Wiege K, Syed SN, Engling L, Piekorz RP, Hirsch E, Nurnberg B, Schmidt RE, Gessner JE. Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-fcgamma receptor activation and immune complex-induced inflammation. J Biol Chem. 2008;283:33296–303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J Immunol. 2006;177:612–20.

Article  CAS  PubMed  Google Scholar 

Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA. Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med. 2006;12:682–7.

Article  CAS  PubMed  Google Scholar 

Yan C, Guan F, Shen Y, Tang H, Yuan D, Gao H, Feng X. Bigelovii A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Blocking NF-kappaB and CCAAT/Enhancer-Binding Protein delta Pathways. Mediators Inflamm 2016, 2016:9201604.

Yan C, Zhu M, Staiger J, Johnson PF, Gao H. C5a-regulated CCAAT/enhancer-binding proteins beta and delta are essential in fcgamma receptor-mediated inflammatory cytokine and chemokine production in macrophages. J Biol Chem. 2012;287:3217–30.

Article  CAS  PubMed  Google Scholar 

Yan C, Li B, Liu X, Deng C, Cai R, Shen Y, Tang H. Involvement of multiple transcription factors in regulation of IL-beta-induced MCP-1 expression in alveolar type II epithelial cells. Mol Immunol. 2019;111:95–105.

Article  CAS  PubMed  Google Scholar 

Yan C, Deng C, Liu X, Chen Y, Ye J, Cai R, Shen Y, Tang H. TNF-alpha induction of IL-6 in alveolar type II epithelial cells: contributions of JNK/c-Jun/AP-1 element, C/EBPdelta/C/EBP binding site and IKK/NF-kappaB p65/kappaB site. Mol Immunol. 2018;101:585–96.

Article  CAS  PubMed  Google Scholar 

Suresh R, Kupfer Y, Tessler S. Acute respiratory distress syndrome. N Engl J Med. 2000;343:660–1.

Article  CAS  PubMed  Google Scholar 

Shaw TD, McAuley DF, O’Kane CM. Emerging drugs for treating the acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2019;24:29–41.

Article  CAS  PubMed