Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) supported Salgado RC (Grant # 130382/2020-5), and Condino-Neto A. The Jeffrey Modell Foundation and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant # 2016/22158-3) supported Condino-Neto A. The Investigator-Initiated Research grant (IISR-2020-103243) from Takeda Pharma Ltda supported Condino-Neto A. PENSI Institute provided administrative support.