aMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori

bOncology and Hemato-Oncology Department, University of Milan

cIFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy

Correspondence to Claudio Vernieri, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan 20133, Italy and IFOM ETS, the AIRC Institute of Molecular Oncology; Via Adamello 16 20139, Milan, Italy. E-mail: [email protected], [email protected]