Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia

Rabinovici J, Goldsmith PC, Roberts VJ, Vaughan J, Vale W, Jaffe RB. Localization and secretion of inhibin/activin subunits in the human and subhuman primate fetal gonads. J Clin Endocrinol Metab. 1991;73(5):1141–9.

Article  CAS  PubMed  Google Scholar 

Westermarck J, Kähäri VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 1999;13(8):781–92.

Article  CAS  PubMed  Google Scholar 

Anon. ACOG Practice Bulletin No. 202: gestational hypertension and Preeclampsia. Obstet Gynecol. 2019;133(1):1.

Google Scholar 

Dimitriadis E, Rolnik DL, Zhou W, Estrada-Gutierrez G, Koga K, Francisco RPV, Whitehead C, Hyett J, da Silva Costa F, Nicolaides K, Menkhorst E. Pre-eclampsia. Nat Rev Dis Primers. 2023;9(1):8.

Article  PubMed  Google Scholar 

Kim HY, Baek HS. Circulating cathepsin B and D in pregnancy. J Obstet Gynaecol. 2019;39(1):17–21.

Article  CAS  PubMed  Google Scholar 

Patel S, Homaei A, El-Seedi HR, Akhtar N. Cathepsins: proteases that are vital for survival but can also be fatal. Biomed Pharmacother. 2018;105:526–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kramer L, Turk D, Turk B. The future of Cysteine cathepsins in Disease Management. Trends Pharmacol Sci. 2017;38(10):873–98.

Article  CAS  PubMed  Google Scholar 

Menkhorst EM, Lane N, Winship AL, Li P, Yap J, Meehan K, Rainczuk A, Stephens A, Dimitriadis E. Decidual-secreted factors alter invasive trophoblast membrane and secreted proteins implying a role for decidual cell regulation of placentation. PLoS ONE. 2012;7(2):e31418.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang XL, Xu FX, Han XY. siRNA-mediated NCAM1 gene silencing suppresses oxidative stress in pre-eclampsia by inhibiting the p38MAPK signaling pathway. J Cell Biochem. 2019;120(11):18608–17.

Article  CAS  PubMed  Google Scholar 

Quan D, Li L, Zuo M. Efficacy of low molecular heparin on Preeclampsia by inhibiting apoptosis of Trophoblasts via the p38MAPK Signaling Pathway. Comput Math Methods Med. 2021;2021:3337514.

Article  PubMed  PubMed Central  Google Scholar 

Kim S, Lee KS, Choi S, Kim J, Lee DK, Park M, Park W, Kim TH, Hwang JY, Won MH, Lee H, Ryoo S, Ha KS, Kwon YG, Kim YM. NF-κB-responsive miRNA-31-5p elicits endothelial dysfunction associated with preeclampsia via down-regulation of endothelial nitric-oxide synthase. J Biol Chem. 2018;293(49):18989–9000.

Article  PubMed  PubMed Central  Google Scholar 

Armistead B, Kadam L, Drewlo S, Kohan-Ghadr HR. The role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the spotlight. Int J Mol Sci. 2020;21(5):1775.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Afonso S, Romagnano L, Babiarz B. Expression of cathepsin proteinases by mouse trophoblast in vivo and in vitro. Dev Dyn. 1999;216(4–5):374–84.

Article  CAS  PubMed  Google Scholar 

Nakajima R, Ishida M, Kamiya CA, Yoshimatsu J, Suzuki M, Hirota A, Ikeda T, Harigaya T. Elevated vasoinhibin derived from prolactin and cathepsin D activities in sera of patients with preeclampsia. Hypertens Res. 2015;38(12):899–901.

Article  CAS  PubMed  Google Scholar 

Kim YN, Kim HK, Warda M, Kim N, Park WS, Prince Adel B, Jeong DH, Lee DS, Kim KT, Han J. Toward a better understanding of preeclampsia: comparative proteomic analysis of preeclamptic placentas. Proteom Clin Appl. 2007;1(12):1625–36.

Article  CAS  Google Scholar 

Kim HY, Lee M, Kang HW, Moon C. Cathepsin D levels are reduced in patients with preeclampsia in korean population. Clin Biochem. 2013;46(18):1808–11.

Article  CAS  PubMed  Google Scholar 

Anık İlhan G, Yıldızhan B. Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia. Turk J Obstet Gynecol. 2019;16(2):91–4.

Article  PubMed  PubMed Central  Google Scholar 

Chappell LC, Cluver CA, Kingdom J, Tong S. Pre-eclampsia. Lancet. 2021;398(10297):341–54.

Article  CAS  PubMed  Google Scholar 

Korkmaz B, Caughey GH, Chapple I, Gauthier F, Hirschfeld J, Jenne DE, Kettritz R, Lalmanach G, Lamort AS, Lauritzen C, Łegowska M, Lesner A, Marchand-Adam S, McKaig SJ, Moss C, Pedersen J, Roberts H, Schreiber A, Seren S, Thakker NS. Therapeutic targeting of cathepsin C: from pathophysiology to treatment. Pharmacol Ther. 2018;190:202–36.

Article  PubMed  Google Scholar 

Dang YZ, Chen XJ, Yu J, Zhao SH, Cao XM, Wang Q. Cathepsin C promotes colorectal cancer metastasis by regulating immune escape through upregulating CSF1. Neoplasma. 2023;70(1):123–35.

Article  CAS  PubMed  Google Scholar 

Yin W, Dong M, Ye D, Liu Q, Liu S, Shi C, Bai H, Wang Q, Yang X, Wang L, Niu W. Cathepsin C promotes the progression of periapical periodontitis. Sci Bull (Beijing). 2020;65(11):951–7.

Article  CAS  PubMed  Google Scholar 

Alam S, Liu Q, Liu S, Liu Y, Zhang Y, Yang X, Liu G, Fan K, Ma J. Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-κB pathway. Exp Cell Res. 2019;382(2):111472.

Article  CAS  PubMed  Google Scholar 

Founds SA, Conley YP, Lyons-Weiler JF, Jeyabalan A, Hogge WA, Conrad KP. Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta. 2009;30(1):15–24.

Article  CAS  PubMed  Google Scholar 

Lu F, Gong H, Lei H, Li J. Downregulation of cathepsin C alleviates endothelial cell dysfunction by suppressing p38 MAPK/NF-κB pathway in preeclampsia. Bioengineered. 2022;13(2):3019–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu Y, Lewis DF, Alexander JS, Wang Y. Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia. Hypertens Res. 2017;40(12):976–81.

Article  CAS  PubMed  Google Scholar 

Briozzo P, Morisset M, Capony F, Rougeot C, Rochefort H. In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells. Cancer Res. 1988;48(13):3688–92.

CAS  PubMed  Google Scholar 

Dahl SW, Halkier T, Lauritzen C, Dolenc I, Pedersen J, Turk V, Turk B. Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing. Biochemistry. 2001;40(6):1671–8.

Article  CAS  PubMed  Google Scholar 

Amarante-Paffaro AM, Hoshida MS, Yokota S, Gonçalves CR, Joazeiro PP, Bevilacqua E, Yamada AT. Localization of cathepsins D and B at the maternal-fetal interface and the invasiveness of the trophoblast during the postimplantation period in the mouse. Cells Tissues Organs. 2011;193(6):417–25.

Article  CAS  PubMed  Google Scholar 

Harris LK, Benagiano M, D’Elios MM, Brosens I, Benagiano G. Placental bed research: II. Functional and immunological investigations of the placental bed. Am J Obstet Gynecol. 2019;221(5):457–69.

Article  CAS  PubMed  Google Scholar 

Hu L, Roth JM, Brooks P, Luty J, Karpatkin S. Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis. Cancer Res. 2008;68(12):4666–73.

Article  CAS  PubMed  Google Scholar 

Tu FF, Goldenberg RL, Tamura T, Drews M, Zucker SJ, Voss HF. Prenatal plasma matrix metalloproteinase-9 levels to predict spontaneous preterm birth. Obstet Gynecol. 1998;92(3):446–9.

CAS  PubMed  Google Scholar 

Triebel J, Schauer N, Zamora M, Moreno-Vega AI, Escalera GM, Clapp C, Bertsch T. Matrix metalloproteases and cathepsin D in human serum do not Cleave Prolactin to Generate Vasoinhibin. Clin Lab. 2020;66(5).

Masumoto A, Masuyama H, Takamoto N, Akahori Y, Hiramatsu Y. Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension. Acta Med Okayama. 2010;64(4):249–55.

CAS  PubMed  Google Scholar 

Kim HY, Kim BW, Kim YJ. Elevated serum cathepsin B concentration in pregnant women is associated with preeclampsia. Arch Gynecol Obstet. 2016;294(6):1145–50.

Article  CAS  PubMed  Google Scholar 

Nakashima A, Cheng SB, Ikawa M, Yoshimori T, Huber WJ, Menon R, Huang Z, Fierce J, Padbury JF, Sadovsky Y, Saito S, Sharma S. Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia. Autophagy. 2020;16(10):1771–85.

Article  CAS  PubMed  Google Scholar 

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